STRINGSTRING
LOC105926591 LOC105926591 ENSFHEP00000005153 ENSFHEP00000005153 LOC105938719 LOC105938719 LOC105932518 LOC105932518 smad2 smad2 LOC105927087 LOC105927087 ENSFHEP00000004435 ENSFHEP00000004435 mad2l1 mad2l1 anapc7 anapc7 ccnd3 ccnd3 mad1l1 mad1l1 PLK1 PLK1 cdkn2c cdkn2c LOC105927103 LOC105927103 rad21 rad21 LOC105918977 LOC105918977 cdc6 cdc6 LOC105936361 LOC105936361 fbxw12 fbxw12 cdc14a cdc14a ENSFHEP00000001965 ENSFHEP00000001965 GADD45B GADD45B LOC105938564 LOC105938564 rb1 rb1 FZR1 FZR1 LOC105931280 LOC105931280 LOC105934647 LOC105934647 LOC105921882 LOC105921882 LOC105929386 LOC105929386 ccna1 ccna1 cdc26 cdc26 TGFB3 TGFB3 smc1a smc1a ENSFHEP00000000227 ENSFHEP00000000227 LOC105940339 LOC105940339 zbtb46 zbtb46 LOC105935255 LOC105935255 ENSFHEP00000034851 ENSFHEP00000034851 cdc20 cdc20 LOC105921341 LOC105921341 ENSFHEP00000034755 ENSFHEP00000034755 pcna pcna LOC105927928 LOC105927928 ENSFHEP00000033534 ENSFHEP00000033534 rbx1 rbx1 skp1 skp1 LOC105930774 LOC105930774 ccnb3 ccnb3 mcm6 mcm6 ENSFHEP00000032303 ENSFHEP00000032303 rbl2 rbl2 abl1 abl1 LOC105928010 LOC105928010 LOC105919244 LOC105919244 sowahd sowahd chek1 chek1 ENSFHEP00000031187 ENSFHEP00000031187 gsk3b gsk3b anapc2 anapc2 LOC105921701 LOC105921701 LOC105936587 LOC105936587 cdc23 cdc23 ENSFHEP00000029768 ENSFHEP00000029768 ENSFHEP00000029520 ENSFHEP00000029520 espl1 espl1 anapc4 anapc4 cdk1 cdk1 zbtb17 zbtb17 mcm4 mcm4 LOC105934358 LOC105934358 LOC105916486 LOC105916486 myc myc ENSFHEP00000027531 ENSFHEP00000027531 LOC105931058 LOC105931058 mdm2 mdm2 mcm5 mcm5 LOC105927529 LOC105927529 GADD45B-2 GADD45B-2 LOC105931481 LOC105931481 ttk ttk LOC105933819 LOC105933819 LOC105931684 LOC105931684 ccnh ccnh LOC105925946 LOC105925946 mcm3 mcm3 LOC105927645 LOC105927645 LOC105916658 LOC105916658 LOC105917186 LOC105917186 cdk7 cdk7 ENSFHEP00000024203 ENSFHEP00000024203 orc4 orc4 YWHAB YWHAB anapc11 anapc11 LOC105921446 LOC105921446 LOC105934010 LOC105934010 ENSFHEP00000021145 ENSFHEP00000021145 ENSFHEP00000020833 ENSFHEP00000020833 ENSFHEP00000020509 ENSFHEP00000020509 ywhae ywhae LOC105922834 LOC105922834 LOC105939869 LOC105939869 LOC105933078 LOC105933078 ep300 ep300 prkdc prkdc ccna2 ccna2 wee1 wee1 LOC105938807 LOC105938807 LOC105928480 LOC105928480 hdac8 hdac8 ywhaz ywhaz ccne1 ccne1 rbl1 rbl1 orc2 orc2 cdc45 cdc45 LOC105931979 LOC105931979 LOC105931356 LOC105931356 LOC105931332 LOC105931332 dbf4 dbf4 HDAC2 HDAC2 ccnd1 ccnd1 tgfb3 tgfb3 stag1 stag1 atr atr LOC105917492 LOC105917492 LOC105935397 LOC105935397 E2F3 E2F3 LOC105930854 LOC105930854 LOC105925280 LOC105925280 LOC105929554 LOC105929554 mcm7 mcm7 LOC105936588 LOC105936588 LOC105920438 LOC105920438 ccne2 ccne2 GADD45A GADD45A anapc10 anapc10 tfdp1 tfdp1 LOC105917003 LOC105917003 znf652 znf652 mad2l2 mad2l2 tmem82 tmem82 zbtb47 zbtb47 orc3 orc3 zbtb10 zbtb10 cdk6 cdk6 LOC105920529 LOC105920529 smc3 smc3 cdk20 cdk20 ENSFHEP00000010787 ENSFHEP00000010787 crebbp crebbp ENSFHEP00000010265 ENSFHEP00000010265 bub3 bub3 LOC105924936 LOC105924936 anapc5 anapc5 cdc16 cdc16 e2f1 e2f1 pkmyt1 pkmyt1 e2f4 e2f4 anapc13 anapc13 fam126b fam126b LOC105933829 LOC105933829 CDC25B CDC25B cdk4 cdk4 ap5s1 ap5s1 LOC105935110 LOC105935110 cdkn2d cdkn2d chek2 chek2 cdk2 cdk2 anapc1 anapc1 orc5 orc5 e2f2 e2f2 skp2 skp2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105926591Wee1-like protein kinase. (571 aa)
ENSFHEP00000005153Uncharacterized protein. (137 aa)
LOC105938719Mothers against decapentaplegic homolog. (467 aa)
LOC105932518Uncharacterized protein. (545 aa)
smad2Mothers against decapentaplegic homolog. (358 aa)
LOC105927087Cyclin-dependent kinase inhibitor 1A. (162 aa)
ENSFHEP00000004435E2F_TDP domain-containing protein. (162 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
anapc7Anaphase promoting complex subunit 7. (580 aa)
ccnd3Cyclin D3; Belongs to the cyclin family. (310 aa)
mad1l1Mitotic arrest deficient 1 like 1. (676 aa)
PLK1Serine/threonine-protein kinase PLK. (581 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (190 aa)
LOC105927103Transmembrane protein 82. (308 aa)
rad21RAD21 cohesin complex component a. (639 aa)
LOC105918977Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (583 aa)
LOC105936361Mothers against decapentaplegic homolog. (427 aa)
fbxw12Si:ch73-142c19.1. (474 aa)
cdc14aCell division cycle 14Ab. (542 aa)
ENSFHEP00000001965TYR_PHOSPHATASE_2 domain-containing protein. (168 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (178 aa)
LOC105938564Cyclin-dependent kinase inhibitor 1Bb. (198 aa)
rb1Retinoblastoma-associated protein. (913 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (497 aa)
LOC105931280Stromal antigen 2b. (1313 aa)
LOC105934647Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (352 aa)
LOC105921882Cyclin B1; Belongs to the cyclin family. (321 aa)
LOC105929386Stromal antigen 2a. (1170 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (407 aa)
cdc26Cell division cycle 26 homolog. (94 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
smc1aStructural maintenance of chromosomes protein. (1211 aa)
ENSFHEP00000000227Cullin 1b; Belongs to the cullin family. (471 aa)
LOC105940339Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (396 aa)
zbtb46Zinc finger and BTB domain containing 46. (596 aa)
LOC105935255RAD21 cohesin complex component like 1. (544 aa)
ENSFHEP00000034851TAN domain-containing protein. (173 aa)
cdc20Cell division cycle 20 homolog. (591 aa)
LOC105921341MH2 domain-containing protein. (222 aa)
ENSFHEP00000034755MH1 domain-containing protein. (154 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC105927928Mothers against decapentaplegic homolog. (425 aa)
ENSFHEP00000033534Uncharacterized protein. (79 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC105930774Mothers against decapentaplegic homolog. (393 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (404 aa)
mcm6DNA helicase; Belongs to the MCM family. (824 aa)
ENSFHEP00000032303IF rod domain-containing protein; Belongs to the intermediate filament family. (248 aa)
rbl2Retinoblastoma-like 2 (p130). (1055 aa)
abl1Tyrosine-protein kinase. (1105 aa)
LOC10592801014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
LOC105919244Growth arrest and DNA-damage-inducible, alpha, a. (160 aa)
sowahdUncharacterized protein. (178 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
ENSFHEP00000031187Uncharacterized protein. (193 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (425 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (757 aa)
LOC105921701SCD domain-containing protein. (1220 aa)
LOC105936587Ribosomal_L7Ae domain-containing protein. (167 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (574 aa)
ENSFHEP00000029768Syntaphilin b. (463 aa)
ENSFHEP00000029520Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (382 aa)
espl1Extra spindle pole bodies like 1, separase. (2190 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (300 aa)
zbtb17Zinc finger and BTB domain containing 17. (910 aa)
mcm4DNA helicase; Belongs to the MCM family. (868 aa)
LOC105934358Uncharacterized protein. (1161 aa)
LOC105916486Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (300 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (432 aa)
ENSFHEP00000027531Uncharacterized protein. (95 aa)
LOC10593105814-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (244 aa)
mdm2MDM2 proto-oncogene. (559 aa)
mcm5DNA helicase; Belongs to the MCM family. (674 aa)
LOC105927529Si:ch211-269e2.1. (1110 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (153 aa)
LOC105931481Cyclin D2, a; Belongs to the cyclin family. (296 aa)
ttkTtk protein kinase. (1002 aa)
LOC105933819Uncharacterized protein. (188 aa)
LOC105931684RAD21 cohesin complex component b. (592 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
LOC105925946Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
mcm3DNA helicase; Belongs to the MCM family. (767 aa)
LOC105927645Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (249 aa)
LOC105916658Myoneurin. (723 aa)
LOC105917186Cyclin Dx; Belongs to the cyclin family. (301 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
ENSFHEP00000024203MH1 domain-containing protein. (95 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (260 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
LOC105921446E2F transcription factor 5. (362 aa)
LOC105934010Cyclin D2, b; Belongs to the cyclin family. (367 aa)
ENSFHEP00000021145Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (575 aa)
ENSFHEP00000020833Uncharacterized protein. (136 aa)
ENSFHEP0000002050914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (168 aa)
ywhae14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
LOC105922834BHLH domain-containing protein. (346 aa)
LOC105939869Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
LOC105933078Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
ep300E1A binding protein p300 b. (2738 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3917 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
wee1Wee1-like protein kinase. (620 aa)
LOC105938807G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (371 aa)
LOC105928480Structural maintenance of chromosomes protein. (1253 aa)
hdac8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (401 aa)
ywhaz14-3-3.a protein; Belongs to the 14-3-3 family. (247 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (433 aa)
rbl1Retinoblastoma-like 1 (p107). (1058 aa)
orc2Origin recognition complex, subunit 2. (573 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (367 aa)
LOC105931979E2F_TDP domain-containing protein. (281 aa)
LOC105931356Uncharacterized protein. (553 aa)
LOC105931332Growth arrest and DNA-damage-inducible, gamma a. (159 aa)
dbf4DBF4 zinc finger. (408 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
stag1Stromal antigen 1a. (1260 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
LOC105917492BUB1 mitotic checkpoint serine/threonine kinase Bb. (435 aa)
LOC105935397Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
E2F3E2F transcription factor 3. (236 aa)
LOC105930854E1A binding protein p300 a. (2838 aa)
LOC105925280Fizzy/cell division cycle 20 related 1b. (487 aa)
LOC105929554Uncharacterized protein. (276 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
LOC105936588Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (154 aa)
LOC105920438Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (395 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (214 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
tfdp1Transcription factor. (425 aa)
LOC1059170033-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
znf652Zinc finger protein 652. (688 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
tmem82Transmembrane protein 82. (348 aa)
zbtb47Zinc finger and BTB domain containing 47b. (761 aa)
orc3Origin recognition complex, subunit 3. (612 aa)
zbtb10Zinc finger and BTB domain containing 10. (581 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
LOC105920529Mothers against decapentaplegic homolog. (520 aa)
smc3Structural maintenance of chromosomes 3. (1155 aa)
cdk20Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily. (344 aa)
ENSFHEP00000010787BUB1 N-terminal domain-containing protein. (79 aa)
crebbpCREB binding protein a. (2270 aa)
ENSFHEP00000010265Uncharacterized protein. (128 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
LOC105924936CREB binding protein b. (2424 aa)
anapc5Anaphase promoting complex subunit 5. (765 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
e2f1E2F transcription factor 1. (454 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (582 aa)
e2f4E2F transcription factor 4. (381 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
fam126bZgc:158316. (553 aa)
LOC105933829Cyclin-dependent kinase inhibitor 1D. (182 aa)
CDC25BM-phase inducer phosphatase 1. (572 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa)
ap5s1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
LOC105935110Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (256 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
chek2Checkpoint kinase 2. (458 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
anapc1Anaphase promoting complex subunit 1. (1979 aa)
orc5Origin recognition complex, subunit 5. (429 aa)
e2f2Si:ch211-160f23.5. (442 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (409 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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