STRINGSTRING
LOC105938805 LOC105938805 ENSFHEP00000034851 ENSFHEP00000034851 serpine1 serpine1 LOC105919244 LOC105919244 ppm1d ppm1d LOC105940339 LOC105940339 LOC105921882 LOC105921882 LOC105934647 LOC105934647 LOC105940225 LOC105940225 LOC105919614 LOC105919614 GADD45B GADD45B TP53I3 TP53I3 LOC105927752 LOC105927752 igf1 igf1 siah2 siah2 LOC105917255 LOC105917255 hps5 hps5 adgrb2 adgrb2 ccnd3 ccnd3 LOC105927087 LOC105927087 bax bax ENSFHEP00000006195 ENSFHEP00000006195 LOC105932136 LOC105932136 rprm rprm cdk2 cdk2 chek2 chek2 cdk4 cdk4 siva1 siva1 LOC105933829 LOC105933829 aifm2 aifm2 tsc2 tsc2 ENSFHEP00000009335 ENSFHEP00000009335 ccng1 ccng1 ENSFHEP00000011407 ENSFHEP00000011407 cdk6 cdk6 LOC105932744 LOC105932744 ei24 ei24 LOC105934296 LOC105934296 GADD45A GADD45A ccne2 ccne2 LOC105918684 LOC105918684 LOC105936588 LOC105936588 LOC105915223 LOC105915223 IGFBP3 IGFBP3 bcl2 bcl2 atr atr LOC105929651 LOC105929651 ccnd1 ccnd1 LOC105931332 LOC105931332 LOC105915784 LOC105915784 ccne1 ccne1 LOC105930243 LOC105930243 ENSFHEP00000017141 ENSFHEP00000017141 STEAP3 STEAP3 LOC105928544 LOC105928544 PTEN PTEN LOC105938807 LOC105938807 LOC105928324 LOC105928324 ENSFHEP00000018863 ENSFHEP00000018863 mdm4 mdm4 ddb2 ddb2 LOC105919133 LOC105919133 LOC105915531 LOC105915531 ENSFHEP00000020833 ENSFHEP00000020833 sesn1 sesn1 cryz cryz LOC105940240 LOC105940240 LOC105924364 LOC105924364 LOC105934010 LOC105934010 zmat3 zmat3 LOC105937269 LOC105937269 LOC105921391 LOC105921391 apaf1 apaf1 LOC105917186 LOC105917186 rchy1 rchy1 LOC105918368 LOC105918368 LOC105918367 LOC105918367 LOC105932888 LOC105932888 LOC105925555 LOC105925555 adgrb3 adgrb3 LOC105938588 LOC105938588 LOC105936335 LOC105936335 LOC105931481 LOC105931481 GADD45B-2 GADD45B-2 LOC105931141 LOC105931141 mdm2 mdm2 steap2 steap2 LOC105916486 LOC105916486 ENSFHEP00000028496 ENSFHEP00000028496 ENSFHEP00000028508 ENSFHEP00000028508 LOC105933356 LOC105933356 cdk1 cdk1 LOC105938393 LOC105938393 LOC105934284 LOC105934284 bcl2l1 bcl2l1 LOC105936587 LOC105936587 LOC105925715 LOC105925715 ENSFHEP00000030199 ENSFHEP00000030199 chek1 chek1 cop1 cop1 casp9 casp9 fam76b fam76b LOC105935336 LOC105935336 perp perp
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105938805Tetraspanin. (255 aa)
ENSFHEP00000034851TAN domain-containing protein. (173 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
LOC105919244Growth arrest and DNA-damage-inducible, alpha, a. (160 aa)
ppm1dProtein phosphatase, Mg2+/Mn2+ dependent, 1Da. (554 aa)
LOC105940339Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (396 aa)
LOC105921882Cyclin B1; Belongs to the cyclin family. (321 aa)
LOC105934647Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (352 aa)
LOC105940225Phosphatase and tensin homolog. (340 aa)
LOC105919614BH4_2 domain-containing protein. (219 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (178 aa)
TP53I3Tumor protein p53 inducible protein 3. (367 aa)
LOC105927752Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (569 aa)
igf1Insulin growth factor I-like protein. (185 aa)
siah2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (327 aa)
LOC105917255P53-induced death domain-containing protein 1. (977 aa)
hps5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1103 aa)
adgrb2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1440 aa)
ccnd3Cyclin D3; Belongs to the cyclin family. (310 aa)
LOC105927087Cyclin-dependent kinase inhibitor 1A. (162 aa)
baxUncharacterized protein. (240 aa)
ENSFHEP00000006195Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
LOC105932136Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
rprmReprimo, TP53 dependent G2 arrest mediator candidate b. (102 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
chek2Checkpoint kinase 2. (458 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa)
siva1SIVA1, apoptosis-inducing factor. (168 aa)
LOC105933829Cyclin-dependent kinase inhibitor 1D. (182 aa)
aifm2Apoptosis inducing factor mitochondria associated 2. (343 aa)
tsc2TSC complex subunit 2. (1700 aa)
ENSFHEP00000009335Uncharacterized protein. (190 aa)
ccng1Cyclin G1; Belongs to the cyclin family. (297 aa)
ENSFHEP00000011407Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (525 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
LOC105932744Reprimo-like. (111 aa)
ei24EI24 autophagy associated transmembrane protein. (341 aa)
LOC105934296Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (214 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (395 aa)
LOC105918684Ribonucleotide reductase M2 polypeptide. (389 aa)
LOC105936588Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (154 aa)
LOC105915223Cyclin G2; Belongs to the cyclin family. (296 aa)
IGFBP3Insulin like growth factor binding protein 3. (285 aa)
bcl2BCL2 apoptosis regulator b. (230 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
LOC105929651E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (339 aa)
ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
LOC105931332Growth arrest and DNA-damage-inducible, gamma a. (159 aa)
LOC105915784Transmembrane phosphatase with tensin homology. (511 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (433 aa)
LOC105930243Uncharacterized protein; Belongs to the peptidase C14A family. (499 aa)
ENSFHEP00000017141Uncharacterized protein. (278 aa)
STEAP3STEAP family member 3, metalloreductase. (514 aa)
LOC105928544Ribonucleotide reductase M2 b. (355 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (414 aa)
LOC105938807G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (371 aa)
LOC105928324Tumor necrosis factor receptor superfamily, member a. (447 aa)
ENSFHEP00000018863Uncharacterized protein. (153 aa)
mdm4MDM4 regulator of p53. (511 aa)
ddb2Damage-specific DNA binding protein 2. (492 aa)
LOC105919133Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (274 aa)
LOC105915531Uncharacterized protein. (390 aa)
ENSFHEP00000020833Uncharacterized protein. (136 aa)
sesn1Sestrin 1. (548 aa)
cryzCrystallin, zeta (quinone reductase). (328 aa)
LOC105940240Uncharacterized protein. (314 aa)
LOC105924364IlGF domain-containing protein. (139 aa)
LOC105934010Cyclin D2, b; Belongs to the cyclin family. (367 aa)
zmat3Zinc finger, matrin-type 3. (279 aa)
LOC105937269CYCLIN domain-containing protein; Belongs to the cyclin family. (402 aa)
LOC105921391Golgin, rab6-interacting. (318 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1260 aa)
LOC105917186Cyclin Dx; Belongs to the cyclin family. (301 aa)
rchy1Uncharacterized protein. (270 aa)
LOC105918368Uncharacterized protein. (378 aa)
LOC105918367Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (292 aa)
LOC105932888Insulin-like growth factor binding protein 3. (284 aa)
LOC105925555Sestrin 2. (558 aa)
adgrb3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1507 aa)
LOC105938588CD82 molecule b; Belongs to the tetraspanin (TM4SF) family. (255 aa)
LOC105936335Thrombospondin 1b. (1169 aa)
LOC105931481Cyclin D2, a; Belongs to the cyclin family. (296 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (153 aa)
LOC105931141Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
mdm2MDM2 proto-oncogene. (559 aa)
steap2STEAP family member 2, metalloreductase. (330 aa)
LOC105916486Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (300 aa)
ENSFHEP00000028496Adhesion G protein-coupled receptor B1b. (615 aa)
ENSFHEP00000028508Uncharacterized protein. (370 aa)
LOC105933356Cytochrome c, somatic b; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (300 aa)
LOC105938393Thrombospondin 1a. (1171 aa)
LOC105934284Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
bcl2l1BCL2 like 1. (229 aa)
LOC105936587Ribosomal_L7Ae domain-containing protein. (167 aa)
LOC105925715Si:zfos-80g12.1. (371 aa)
ENSFHEP00000030199Uncharacterized protein. (438 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
cop1COP1 E3 ubiquitin ligase. (695 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
fam76bFamily with sequence similarity 76 member B. (280 aa)
LOC105935336Adhesion G protein-coupled receptor B1a; Belongs to the G-protein coupled receptor 2 family. (1328 aa)
perpP53 apoptosis effector PMP-22-like protein. (184 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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