(117 nodes) Toll-like receptor signaling pathway network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105915597	Uncharacterized protein. (252 aa)
	ENSFHEP00000033866	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1055 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1034 aa)
	LOC105929744	SCY domain-containing protein. (93 aa)
	fadd	Uncharacterized protein. (195 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	ENSFHEP00000032706	Uncharacterized protein. (499 aa)
	stat1	Signal transducer and activator of transcription. (762 aa)
	LOC105934240	Mitogen-activated protein kinase. (364 aa)
	LOC105919258	Interleukin-1 receptor-associated kinase 1. (709 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (274 aa)
	LOC105929802	Mitogen-activated protein kinase. (362 aa)
	tlr3	Toll-like receptor 3. (914 aa)
	ENSFHEP00000030377	Uncharacterized protein. (119 aa)
	LOC105925284	Uncharacterized protein. (518 aa)
	LOC105917085	Mitogen-activated protein kinase. (420 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (584 aa)
	LOC105930502	Transmembrane p24 trafficking protein 3. (253 aa)
	LOC105937903	Uncharacterized protein. (181 aa)
	LOC105916522	Signal transducer and activator of transcription. (765 aa)
	LOC105928264	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (141 aa)
	ENSFHEP00000026200	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (436 aa)
	ENSFHEP00000026034	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (504 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC105935606	Uncharacterized protein. (193 aa)
	LOC105931725	Mitogen-activated protein kinase. (360 aa)
	map2k1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (765 aa)
	ENSFHEP00000023391	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (163 aa)
	LOC105936911	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (996 aa)
	LOC105931232	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC105940337	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
	LOC105922040	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC105937526	Uncharacterized protein. (236 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (462 aa)
	LOC105921456	Transmembrane p24 trafficking protein 7. (228 aa)
	LOC105938151	Interleukin-1. (297 aa)
	LOC105939855	Toll-like receptor 1. (799 aa)
	LOC105925551	RHD domain-containing protein. (633 aa)
	LOC105916784	Uncharacterized protein. (315 aa)
	ENSFHEP00000020243	Protein kinase domain-containing protein. (116 aa)
	LOC105925504	SCY domain-containing protein. (93 aa)
	ikbke	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (721 aa)
	ccl22	SCY domain-containing protein. (96 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (314 aa)
	ENSFHEP00000019134	Uncharacterized protein. (103 aa)
	ENSFHEP00000019123	SCY domain-containing protein. (83 aa)
	ENSFHEP00000018231	Toll-like receptor 9; Belongs to the Toll-like receptor family. (1071 aa)
	LOC105927955	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC105939894	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (479 aa)
	tollip	Toll interacting protein. (275 aa)
	LOC105927386	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (420 aa)
	REL	REL proto-oncogene, NF-kB subunit. (630 aa)
	LOC105930243	Uncharacterized protein; Belongs to the peptidase C14A family. (499 aa)
	LOC105935904	Uncharacterized protein. (200 aa)
	LOC105922998	TRIF-NTD domain-containing protein. (580 aa)
	LOC105922293	C-X-C motif chemokine. (104 aa)
	LOC105917182	V-fos FBJ murine osteosarcoma viral oncogene homolog Aa. (373 aa)
	LOC105930852	Mitogen-activated protein kinase. (408 aa)
	LOC105924928	TIR domain-containing protein; Belongs to the Toll-like receptor family. (1004 aa)
	LOC105934578	Bactericidal permeability-increasing protein. (473 aa)
	ENSFHEP00000015299	TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
	LOC105935437	Uncharacterized protein. (641 aa)
	LOC105925186	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC105929835	Mitogen-activated protein kinase. (361 aa)
	nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (949 aa)
	map2k4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (433 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (676 aa)
	ENSFHEP00000013297	BZIP domain-containing protein; Belongs to the bZIP family. (323 aa)
	ENSFHEP00000013026	JunE proto-oncogene, AP-1 transcription factor subunit. (334 aa)
	LOC105930058	Ras-related C3 botulinum toxin substrate 1. (192 aa)
	LOC105917579	TIR domain-containing protein. (810 aa)
	LOC105917580	TIR domain-containing protein. (823 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	LOC105936094	Interferon regulatory factor 5. (489 aa)
	ENSFHEP00000011198	Protein kinase domain-containing protein. (225 aa)
	ENSFHEP00000011114	Uncharacterized protein. (191 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	LOC105924471	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (296 aa)
	LOC105925855	Mitogen-activated protein kinase. (363 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (744 aa)
	ENSFHEP00000010024	Uncharacterized protein. (206 aa)
	tbk1	TANK-binding kinase 1. (453 aa)
	LOC105926483	Dual specificity mitogen-activated protein kinase kinase 3. (358 aa)
	LOC105917075	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (355 aa)
	LOC105918227	Interferon regulatory factor 7. (438 aa)
	LOC105920054	Uncharacterized protein. (497 aa)
	LOC105936595	Cathepsin K; Belongs to the peptidase C1 family. (330 aa)
	LOC105936620	Toll-like receptor 18. (873 aa)
	LOC105937012	Component of inhibitor of nuclear factor kappa B kinase complex. (703 aa)
	map3k8	Mitogen-activated protein kinase kinase kinase 8. (468 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	ENSFHEP00000006195	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	LOC105928347	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (298 aa)
	LOC105935604	Uncharacterized protein. (289 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (729 aa)
	LOC105923990	Uncharacterized protein. (722 aa)
	LOC105927135	Interferon regulatory factor 6. (439 aa)
	LOC105938746	SCY domain-containing protein. (136 aa)
	LOC105930636	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (354 aa)
	LOC105931778	Mitogen-activated protein kinase. (357 aa)
	LOC105938700	Mitogen-activated protein kinase. (460 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (593 aa)
	mapk10	Mitogen-activated protein kinase 10. (411 aa)
	LOC105935716	Rac family small GTPase 3b. (192 aa)
	LOC105926891	CD40 molecule, TNF receptor superfamily member 5. (308 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (423 aa)
	LOC105926671	Interferon regulatory factor 3. (465 aa)
	LOC105915567	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
	LOC105919032	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (481 aa)
	LOC105936405	BPI fold containing family C, like. (476 aa)
	LOC105929477	Si:ch211-153j24.3. (318 aa)
	LOC105929553	V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (364 aa)
	LOC105922044	Uncharacterized protein. (116 aa)
	LOC105928914	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (324 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSFHEP00000015299	ENSFHEP00000023665	ENSFHEP00000015299	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.452
CHUK	ENSFHEP00000018231	ENSFHEP00000023665	ENSFHEP00000018231	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor 9; Belongs to the Toll-like receptor family.	0.427
CHUK	ENSFHEP00000020243	ENSFHEP00000023665	ENSFHEP00000020243	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.947
CHUK	ENSFHEP00000026200	ENSFHEP00000023665	ENSFHEP00000026200	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.974
CHUK	LOC105916522	ENSFHEP00000023665	ENSFHEP00000027201	Component of inhibitor of nuclear factor kappa B kinase complex.	Signal transducer and activator of transcription.	0.536
CHUK	LOC105917579	ENSFHEP00000023665	ENSFHEP00000012463	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.414
CHUK	LOC105917580	ENSFHEP00000023665	ENSFHEP00000011948	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.414
CHUK	LOC105918227	ENSFHEP00000023665	ENSFHEP00000008766	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 7.	0.976
CHUK	LOC105919032	ENSFHEP00000023665	ENSFHEP00000001672	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.970
CHUK	LOC105919258	ENSFHEP00000023665	ENSFHEP00000031721	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin-1 receptor-associated kinase 1.	0.940
CHUK	LOC105921456	ENSFHEP00000023665	ENSFHEP00000020740	Component of inhibitor of nuclear factor kappa B kinase complex.	Transmembrane p24 trafficking protein 7.	0.492
CHUK	LOC105922998	ENSFHEP00000023665	ENSFHEP00000016515	Component of inhibitor of nuclear factor kappa B kinase complex.	TRIF-NTD domain-containing protein.	0.492
CHUK	LOC105923990	ENSFHEP00000023665	ENSFHEP00000004916	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.414
CHUK	LOC105925551	ENSFHEP00000023665	ENSFHEP00000020246	Component of inhibitor of nuclear factor kappa B kinase complex.	RHD domain-containing protein.	0.785
CHUK	LOC105926671	ENSFHEP00000023665	ENSFHEP00000002063	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 3.	0.581
CHUK	LOC105927955	ENSFHEP00000023665	ENSFHEP00000018158	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.966
CHUK	LOC105930502	ENSFHEP00000023665	ENSFHEP00000028050	Component of inhibitor of nuclear factor kappa B kinase complex.	Transmembrane p24 trafficking protein 3.	0.492
CHUK	LOC105930636	ENSFHEP00000023665	ENSFHEP00000003925	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.971
CHUK	LOC105931232	ENSFHEP00000023665	ENSFHEP00000022260	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.966
CHUK	LOC105937012	ENSFHEP00000023665	ENSFHEP00000006608	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.950