(124 nodes) Preribosome, and Ribosome biogenesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pdcd11	Programmed cell death 11. (1810 aa)
	pno1	Partner of NOB1 homolog. (252 aa)
	LOC103466821	Zona pellucida glycoprotein d. (394 aa)
	rbm19	RNA binding motif protein 19. (921 aa)
	rtca	RNA 3'-terminal phosphate cyclase. (366 aa)
	noc3l	NOC3-like DNA replication regulator. (1039 aa)
	bud23	BUD23 rRNA methyltransferase and ribosome maturation factor. (391 aa)
	riok2	RIO kinase 2 (yeast). (520 aa)
	utp23	UTP23 small subunit processome component. (255 aa)
	bms1	BMS1 ribosome biogenesis factor. (1311 aa)
	ddx31	RNA helicase. (912 aa)
	gnl3	Guanine nucleotide binding protein-like 3 (nucleolar). (521 aa)
	dimt1	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (338 aa)
	rrp9	Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (483 aa)
	bysl	Bystin-like. (442 aa)
	esf1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae). (770 aa)
	nol10	Nucleolar protein 10. (718 aa)
	nol6	Nucleolar protein 6. (1145 aa)
	wdr43	WD repeat domain 43. (651 aa)
	utp25	UTP25 small subunit processor component. (748 aa)
	utp3	UTP3 small subunit processome component. (472 aa)
	ENSPREP00000008270	WD_REPEATS_REGION domain-containing protein. (129 aa)
	gnl2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (740 aa)
	utp11	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (252 aa)
	ENSPREP00000008920	Uncharacterized protein. (97 aa)
	mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (237 aa)
	LOC103468877	Peter pan homolog. (532 aa)
	ENSPREP00000009317	Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family. (310 aa)
	gcc1	GRIP and coiled-coil domain containing 1. (757 aa)
	imp3	IMP U3 small nucleolar ribonucleoprotein 3. (183 aa)
	noc4l	Nucleolar complex associated 4 homolog. (526 aa)
	Wdr74	WD repeat domain 74. (306 aa)
	nob1	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (457 aa)
	glmn	Glomulin, FKBP associated protein a. (611 aa)
	grwd1	Glutamate-rich WD repeat containing 1. (448 aa)
	rcl1	RNA terminal phosphate cyclase-like 1. (372 aa)
	nsun6	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (457 aa)
	nifk	Nucleolar protein interacting with the FHA domain of MKI67. (268 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (431 aa)
	nom1	Nucleolar protein with MIF4G domain 1. (830 aa)
	Ddx18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family. (310 aa)
	tsr1	TSR1 ribosome maturation factor. (850 aa)
	utp15	UTP15 small subunit processome component. (528 aa)
	emg1	EMG1 N1-specific pseudouridine methyltransferase. (289 aa)
	nop2	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (688 aa)
	LOC103482313	Neuroguidin, EIF4E binding protein. (447 aa)
	ddx49	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family. (475 aa)
	dhx37	DEAH (Asp-Glu-Ala-His) box polypeptide 37. (1154 aa)
	pwp1	PWP1 homolog, endonuclein. (493 aa)
	nip7	NIP7 nucleolar pre-rRNA processing protein. (133 aa)
	cebpz	CCAAT enhancer binding protein zeta. (976 aa)
	utp18	WD_REPEATS_REGION domain-containing protein. (533 aa)
	pa2g4	Proliferation-associated 2G4, a. (390 aa)
	LOC103463292	Usher syndrome 1C binding protein 1. (792 aa)
	abt1	Activator of basal transcription 1. (274 aa)
	utp6	UTP6 small subunit processome component. (603 aa)
	utp20	UTP20 small subunit processome component. (2602 aa)
	dnttip2	Deoxynucleotidyltransferase, terminal, interacting protein 2. (833 aa)
	aatf	Apoptosis antagonizing transcription factor. (548 aa)
	krr1	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (381 aa)
	imp4	IMP U3 small nucleolar ribonucleoprotein 4. (291 aa)
	wdr12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
	ENSPREP00000020870	Glomulin, FKBP associated protein b. (493 aa)
	nop58	NOP58 ribonucleoprotein homolog (yeast). (455 aa)
	rbm28	RNA binding motif protein 28. (760 aa)
	ddx54	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (855 aa)
	Rrp15	Ribosomal RNA processing 15 homolog. (281 aa)
	ddx24	DEAD (Asp-Glu-Ala-Asp) box helicase 24. (828 aa)
	rpf1	Ribosome production factor 1 homolog. (350 aa)
	kri1	KRI1 homolog. (752 aa)
	rsl24d1	Ribosomal L24 domain containing 1. (164 aa)
	ftsj3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (859 aa)
	ddx56	DEAD (Asp-Glu-Ala-Asp) box helicase 56. (565 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (556 aa)
	LOC103482453	UTP14C small subunit processome component. (763 aa)
	bop1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (751 aa)
	cep152	Centrosomal protein 152. (1040 aa)
	ddx47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; Belongs to the DEAD box helicase family. (499 aa)
	Ddx27	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family. (340 aa)
	LOC103482370	Uncharacterized protein. (834 aa)
	LOC103473717	PWP2 small subunit processome component. (914 aa)
	dcaf13	Ddb1 and cul4 associated factor 13. (445 aa)
	nat10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (955 aa)
	Heatr1	BP28CT domain-containing protein. (345 aa)
	ENSPREP00000024047	Uncharacterized protein. (150 aa)
	rrp7a	Ribosomal RNA processing 7 homolog A. (306 aa)
	rsl1d1	Ribosomal L1 domain containing 1. (393 aa)
	ddx55	RNA helicase. (592 aa)
	wdr46	WD repeat domain 46. (553 aa)
	ddx52	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52. (654 aa)
	nop14	NOP14 nucleolar protein homolog (yeast). (871 aa)
	wdr36	WD repeat domain 36. (793 aa)
	mak16	Protein MAK16 homolog; Belongs to the MAK16 family. (282 aa)
	brix1	Brix domain containing 2. (374 aa)
	pak1ip1	PAK1 interacting protein 1. (361 aa)
	fbl	Fibrillarin. (310 aa)
	LOC103467472	Nuclear receptor coactivator 6. (2360 aa)
	utp4	UTP4 small subunit processome component. (684 aa)
	fcf1	FCF1 rRNA-processing protein. (197 aa)
	sdad1	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (682 aa)
	ENSPREP00000028727	Uncharacterized protein. (64 aa)
	Wdr3	Uncharacterized protein. (97 aa)
	pum3	CPL domain-containing protein. (440 aa)
	ddx10	RNA helicase. (817 aa)
	LOC103467913	Premelanosome protein b. (610 aa)
	lyar	Ly1 antibody reactive homolog (mouse). (322 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (604 aa)
	rrs1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (308 aa)
	snu13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
	znf593	Zinc finger protein 593. (129 aa)
	rpf2	Ribosome production factor 2 homolog. (305 aa)
	rrp12	Ribosomal RNA processing 12 homolog. (1289 aa)
	ltv1	LTV1 ribosome biogenesis factor. (491 aa)
	nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae). (242 aa)
	nop56	NOP56 ribonucleoprotein homolog. (530 aa)
	ebna1bp2	EBNA1 binding protein 2. (309 aa)
	surf6	Surfeit 6. (305 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (551 aa)
	nop9	Uncharacterized protein. (686 aa)
	pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (548 aa)
	mphosph10	U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (665 aa)
	rrp36	Ribosomal RNA processing 36. (349 aa)
	rbm34	RNA binding motif protein 34. (415 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ddx18	Ddx27	ENSPREP00000013137	ENSPREP00000023111	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family.	0.916
Ddx18	ENSPREP00000008270	ENSPREP00000013137	ENSPREP00000008270	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	WD_REPEATS_REGION domain-containing protein.	0.933
Ddx18	ENSPREP00000008920	ENSPREP00000013137	ENSPREP00000008920	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.857
Ddx18	ENSPREP00000009317	ENSPREP00000013137	ENSPREP00000009317	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family.	0.878
Ddx18	ENSPREP00000020870	ENSPREP00000013137	ENSPREP00000020870	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Glomulin, FKBP associated protein b.	0.604
Ddx18	ENSPREP00000024047	ENSPREP00000013137	ENSPREP00000024047	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.825
Ddx18	ENSPREP00000028727	ENSPREP00000013137	ENSPREP00000028727	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.783
Ddx18	Heatr1	ENSPREP00000013137	ENSPREP00000024035	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	BP28CT domain-containing protein.	0.825
Ddx18	LOC103463292	ENSPREP00000013137	ENSPREP00000018662	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Usher syndrome 1C binding protein 1.	0.541
Ddx18	LOC103466821	ENSPREP00000013137	ENSPREP00000001438	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Zona pellucida glycoprotein d.	0.943
Ddx18	LOC103467472	ENSPREP00000013137	ENSPREP00000027241	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Nuclear receptor coactivator 6.	0.540
Ddx18	LOC103467913	ENSPREP00000013137	ENSPREP00000028928	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Premelanosome protein b.	0.676
Ddx18	LOC103468877	ENSPREP00000013137	ENSPREP00000009298	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Peter pan homolog.	0.878
Ddx18	LOC103473717	ENSPREP00000013137	ENSPREP00000023564	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	PWP2 small subunit processome component.	0.995
Ddx18	LOC103482313	ENSPREP00000013137	ENSPREP00000016575	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Neuroguidin, EIF4E binding protein.	0.667
Ddx18	LOC103482370	ENSPREP00000013137	ENSPREP00000023230	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.975
Ddx18	LOC103482453	ENSPREP00000013137	ENSPREP00000022763	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	UTP14C small subunit processome component.	0.985
Ddx18	Rrp15	ENSPREP00000013137	ENSPREP00000021414	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Ribosomal RNA processing 15 homolog.	0.927
Ddx18	Wdr3	ENSPREP00000013137	ENSPREP00000028739	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.783
Ddx18	Wdr74	ENSPREP00000013137	ENSPREP00000010858	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	WD repeat domain 74.	0.994