(73 nodes) Glycerolipid metabolism, and Fatty acid metabolism network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103464949	Zgc:123305. (969 aa)
	LOC103481451	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (334 aa)
	ppt2	Palmitoyl-protein thioesterase 2. (301 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (187 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (691 aa)
	dgke	Diacylglycerol kinase. (593 aa)
	LOC103469802	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (457 aa)
	LOC103477738	Zgc:66024. (300 aa)
	LOC103471032	Phospholipase D family, member 7. (636 aa)
	ENSPREP00000005506	Uncharacterized protein. (172 aa)
	LOC103475331	AMP-binding domain-containing protein. (685 aa)
	pgs1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (543 aa)
	LOC103476593-2	Cardiolipin synthase 1. (345 aa)
	mboat2	Membrane bound O-acyltransferase domain containing 2a; Belongs to the membrane-bound acyltransferase family. (496 aa)
	ENSPREP00000007505	PNPLA domain-containing protein. (262 aa)
	acsl1	Acyl-CoA synthetase long chain family member 1a. (698 aa)
	tamm41	Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (343 aa)
	LOC103467628	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
	LOC103470507	Acyl-CoA synthetase long chain family member 2. (699 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (376 aa)
	rmdn1	Regulator of microtubule dynamics 1. (308 aa)
	lpgat1	Lysophosphatidylglycerol acyltransferase 1. (368 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (490 aa)
	LOC103469930	AMP-binding domain-containing protein. (699 aa)
	acsbg2	Acyl-CoA synthetase bubblegum family member 2. (798 aa)
	lpcat4	Lysophosphatidylcholine acyltransferase 4. (474 aa)
	lipg	Lipase, endothelial. (446 aa)
	dgkk	Diacylglycerol kinase. (1090 aa)
	mogat2	Monoacylglycerol O-acyltransferase 2. (252 aa)
	dgat2	Diacylglycerol O-acyltransferase 2. (365 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (388 aa)
	LOC103470001	1-acylglycerol-3-phosphate O-acyltransferase 9, like. (446 aa)
	acsl3	Uncharacterized protein. (719 aa)
	gpd1	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
	DGKQ	Diacylglycerol kinase. (895 aa)
	LOC103473716	Glycerol-3-phosphate acyltransferase 4. (457 aa)
	ENSPREP00000016743	Uncharacterized protein. (269 aa)
	LOC103470045	Phospholipid phosphatase 5. (266 aa)
	pnpla2	Patatin-like phospholipase domain containing 2. (489 aa)
	lpin1	Si:ch73-21k16.1. (902 aa)
	DGAT1	O-acyltransferase. (523 aa)
	LOC103462762	Lipin 1. (954 aa)
	LOC103468298	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family. (788 aa)
	LOC103470060	Glycerol-3-phosphate acyltransferase 2, mitochondrial. (800 aa)
	lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (517 aa)
	gpat3	Glycerol-3-phosphate acyltransferase 3. (459 aa)
	LOC103463532	PLAT domain-containing protein. (507 aa)
	dgka	Diacylglycerol kinase. (720 aa)
	agpat3	1-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
	cpt1b	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family. (787 aa)
	LOC103479825	Lipin 2. (906 aa)
	LOC103473542	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (397 aa)
	pisd	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (403 aa)
	LOC103479395	Acyl-CoA synthetase long chain family member 3b. (709 aa)
	ENSPREP00000025671	Lysophosphatidylcholine acyltransferase 1. (490 aa)
	LOC103476842	Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. (387 aa)
	LOC103469764	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (462 aa)
	LOC103459750	Patatin-like phospholipase domain containing 3. (473 aa)
	pld3	Phospholipase D family, member 3. (446 aa)
	LOC103478641	O-acyltransferase. (447 aa)
	LOC103467428	PNPLA domain-containing protein. (435 aa)
	LOC103466156	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family. (772 aa)
	agk	Acylglycerol kinase. (423 aa)
	LOC103470977	Acyl-CoA synthetase long chain family member 4a. (567 aa)
	dgkb	Diacylglycerol kinase. (777 aa)
	LOC103473378	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (271 aa)
	Pld4	Uncharacterized protein. (71 aa)
	LOC103481241	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (783 aa)
	agpat5	1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon). (365 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (818 aa)
	LOC103475773	Monoacylglycerol O-acyltransferase 3b. (326 aa)
	agpat4	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta). (394 aa)
	lipc	Lipase, hepatic a. (501 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	ENSPREP00000007505	ENSPREP00000003059	ENSPREP00000007505	Acyl-CoA synthetase long chain family member 1.	PNPLA domain-containing protein.	0.614
ACSL1	ENSPREP00000016743	ENSPREP00000003059	ENSPREP00000016743	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.624
ACSL1	LOC103459750	ENSPREP00000003059	ENSPREP00000026453	Acyl-CoA synthetase long chain family member 1.	Patatin-like phospholipase domain containing 3.	0.627
ACSL1	LOC103463532	ENSPREP00000003059	ENSPREP00000018535	Acyl-CoA synthetase long chain family member 1.	PLAT domain-containing protein.	0.607
ACSL1	LOC103466156	ENSPREP00000003059	ENSPREP00000029364	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family.	0.687
ACSL1	LOC103467428	ENSPREP00000003059	ENSPREP00000029147	Acyl-CoA synthetase long chain family member 1.	PNPLA domain-containing protein.	0.619
ACSL1	LOC103468298	ENSPREP00000003059	ENSPREP00000017986	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family.	0.687
ACSL1	LOC103469930	ENSPREP00000003059	ENSPREP00000011737	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.675
ACSL1	LOC103470507	ENSPREP00000003059	ENSPREP00000009617	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 2.	0.609
ACSL1	LOC103470977	ENSPREP00000003059	ENSPREP00000030920	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 4a.	0.765
ACSL1	LOC103475331	ENSPREP00000003059	ENSPREP00000005590	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.607
ACSL1	LOC103477738	ENSPREP00000003059	ENSPREP00000004750	Acyl-CoA synthetase long chain family member 1.	Zgc:66024.	0.655
ACSL1	LOC103479395	ENSPREP00000003059	ENSPREP00000025116	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 3b.	0.763
ACSL1	LOC103481241	ENSPREP00000003059	ENSPREP00000032406	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family.	0.687
ACSL1	acsbg2	ENSPREP00000003059	ENSPREP00000012918	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase bubblegum family member 2.	0.686
ACSL1	acsl1	ENSPREP00000003059	ENSPREP00000007641	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 1a.	0.605
ACSL1	acsl3	ENSPREP00000003059	ENSPREP00000015628	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.763
ACSL1	cpt1b	ENSPREP00000003059	ENSPREP00000022416	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family.	0.693
ACSL1	lipc	ENSPREP00000003059	ENSPREP00000034321	Acyl-CoA synthetase long chain family member 1.	Lipase, hepatic a.	0.607
ACSL1	lipg	ENSPREP00000003059	ENSPREP00000013906	Acyl-CoA synthetase long chain family member 1.	Lipase, endothelial.	0.617