(43 nodes) Mixed, incl. Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	noc3l	NOC3-like DNA replication regulator. (1039 aa)
	gnl3	Guanine nucleotide binding protein-like 3 (nucleolar). (521 aa)
	gnl2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (740 aa)
	mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (237 aa)
	LOC103468877	Peter pan homolog. (532 aa)
	Wdr74	WD repeat domain 74. (306 aa)
	nsun6	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (457 aa)
	nifk	Nucleolar protein interacting with the FHA domain of MKI67. (268 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (431 aa)
	Ddx18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family. (310 aa)
	nop2	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (688 aa)
	nip7	NIP7 nucleolar pre-rRNA processing protein. (133 aa)
	cebpz	CCAAT enhancer binding protein zeta. (976 aa)
	pa2g4	Proliferation-associated 2G4, a. (390 aa)
	wdr12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
	rbm28	RNA binding motif protein 28. (760 aa)
	ddx54	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (855 aa)
	ddx24	DEAD (Asp-Glu-Ala-Asp) box helicase 24. (828 aa)
	rpf1	Ribosome production factor 1 homolog. (350 aa)
	rsl24d1	Ribosomal L24 domain containing 1. (164 aa)
	ftsj3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (859 aa)
	ddx56	DEAD (Asp-Glu-Ala-Asp) box helicase 56. (565 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (556 aa)
	bop1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (751 aa)
	cep152	Centrosomal protein 152. (1040 aa)
	Ddx27	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family. (340 aa)
	LOC103482370	Uncharacterized protein. (834 aa)
	rsl1d1	Ribosomal L1 domain containing 1. (393 aa)
	ddx55	RNA helicase. (592 aa)
	mak16	Protein MAK16 homolog; Belongs to the MAK16 family. (282 aa)
	brix1	Brix domain containing 2. (374 aa)
	sdad1	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (682 aa)
	pum3	CPL domain-containing protein. (440 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (604 aa)
	rrs1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (308 aa)
	znf593	Zinc finger protein 593. (129 aa)
	rpf2	Ribosome production factor 2 homolog. (305 aa)
	nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae). (242 aa)
	ebna1bp2	EBNA1 binding protein 2. (309 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (551 aa)
	pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (548 aa)
	rbm34	RNA binding motif protein 34. (415 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ddx18	Ddx27	ENSPREP00000013137	ENSPREP00000023111	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family.	0.916
Ddx18	LOC103468877	ENSPREP00000013137	ENSPREP00000009298	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Peter pan homolog.	0.878
Ddx18	LOC103482370	ENSPREP00000013137	ENSPREP00000023230	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.975
Ddx18	Wdr74	ENSPREP00000013137	ENSPREP00000010858	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	WD repeat domain 74.	0.994
Ddx18	bop1	ENSPREP00000013137	ENSPREP00000022894	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.990
Ddx18	brix1	ENSPREP00000013137	ENSPREP00000025881	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Brix domain containing 2.	0.991
Ddx18	cebpz	ENSPREP00000013137	ENSPREP00000018283	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	CCAAT enhancer binding protein zeta.	0.978
Ddx18	cep152	ENSPREP00000013137	ENSPREP00000023061	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Centrosomal protein 152.	0.990
Ddx18	ddx24	ENSPREP00000013137	ENSPREP00000021487	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 24.	0.979
Ddx18	ddx54	ENSPREP00000013137	ENSPREP00000021276	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.923
Ddx18	ddx55	ENSPREP00000013137	ENSPREP00000024681	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	RNA helicase.	0.932
Ddx18	ddx56	ENSPREP00000013137	ENSPREP00000022478	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 56.	0.946
Ddx18	ebna1bp2	ENSPREP00000013137	ENSPREP00000031115	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	EBNA1 binding protein 2.	0.988
Ddx18	ftsj3	ENSPREP00000013137	ENSPREP00000022015	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.993
Ddx18	gnl2	ENSPREP00000013137	ENSPREP00000008802	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.989
Ddx18	gnl3	ENSPREP00000013137	ENSPREP00000004179	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Guanine nucleotide binding protein-like 3 (nucleolar).	0.988
Ddx18	gnl3l	ENSPREP00000013137	ENSPREP00000032461	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	0.988
Ddx18	gtpbp4	ENSPREP00000013137	ENSPREP00000029369	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.997
Ddx18	mak16	ENSPREP00000013137	ENSPREP00000025730	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.985
Ddx18	mrto4	ENSPREP00000013137	ENSPREP00000009164	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Belongs to the DEAD box helicase family.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.992