(50 nodes) RHO GTPases Activate WASPs and WAVEs network (Poecilia reticulata)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103462254	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (380 aa)
	LOC103462249	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (365 aa)
	LOC103462148	Uncharacterized protein. (375 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
	ABI1	Abl-interactor 1a. (577 aa)
	wasf1	WASP family member 1. (537 aa)
	ENSPREP00000003699	SH3 domain-containing protein. (137 aa)
	ENSPREP00000003717	Uncharacterized protein. (76 aa)
	was	WASP actin nucleation promoting factor a. (529 aa)
	LOC103475930	Zgc:101810; Belongs to the actin family. (394 aa)
	LOC103468820	BAI1-associated protein 2a. (549 aa)
	scrn2	Secernin 2. (419 aa)
	ENSPREP00000005261	Si:ch211-1o7.3. (382 aa)
	BRK1	BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
	nckap1	NCK-associated protein 1. (1132 aa)
	wasf2	WASP family member 2. (521 aa)
	LOC103474020	Uncharacterized protein; Belongs to the actin family. (382 aa)
	scrn3	Secernin 3. (418 aa)
	nckipsd	NCK interacting protein with SH3 domain. (752 aa)
	LOC103468132	Zgc:86896. (356 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	ENSPREP00000010144	Uncharacterized protein. (200 aa)
	arpc3	Actin related protein 2/3 complex, subunit 3. (203 aa)
	nckap1l	NCK associated protein 1 like. (1096 aa)
	ENSPREP00000011021	Zgc:158689. (477 aa)
	ENSPREP00000013033	Uncharacterized protein. (170 aa)
	LOC103460840	Uncharacterized protein; Belongs to the actin family. (387 aa)
	LOC103468246	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
	LOC103480395	Zgc:109889. (564 aa)
	ACTR3C	Actin related protein 3C; Belongs to the actin family. (418 aa)
	LOC103460195	Uncharacterized protein. (594 aa)
	LOC103469015	ABI family, member 3a. (466 aa)
	LOC103465240	Actin related protein 2/3 complex, subunit 4. (231 aa)
	gpbar1	G protein-coupled bile acid receptor 1. (345 aa)
	arpc2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (188 aa)
	LOC103479201	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
	LOC103465991	WASP like actin nucleation promoting factor a. (525 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	abi2	Uncharacterized protein. (491 aa)
	BAIAP2	BAI1 associated protein 2. (569 aa)
	ACTR3	Actin related protein 3; Belongs to the actin family. (418 aa)
	ARPC4	Actin related protein 2/3 complex subunit 4. (195 aa)
	LOC103470791	Uncharacterized protein. (372 aa)
	LOC103463911	Cytoplasmic FMR1 interacting protein 1. (1057 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	wasf3	WASP family member 3b. (493 aa)
	LOC103481975	Uncharacterized protein. (191 aa)
	LOC103475416	WH2 domain-containing protein. (461 aa)
	LOC103470899	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	ENSPREP00000032937	SH3 domain-containing protein. (87 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	ACTR3	ENSPREP00000001513	ENSPREP00000024165	Abl-interactor 1a.	Actin related protein 3; Belongs to the actin family.	0.495
ABI1	ACTR3C	ENSPREP00000001513	ENSPREP00000015853	Abl-interactor 1a.	Actin related protein 3C; Belongs to the actin family.	0.495
ABI1	ARPC4	ENSPREP00000001513	ENSPREP00000024920	Abl-interactor 1a.	Actin related protein 2/3 complex subunit 4.	0.801
ABI1	BAIAP2	ENSPREP00000001513	ENSPREP00000022196	Abl-interactor 1a.	BAI1 associated protein 2.	0.714
ABI1	BRK1	ENSPREP00000001513	ENSPREP00000005424	Abl-interactor 1a.	BRICK1 subunit of SCAR/WAVE actin nucleating complex.	0.984
ABI1	ENSPREP00000005261	ENSPREP00000001513	ENSPREP00000005261	Abl-interactor 1a.	Si:ch211-1o7.3.	0.462
ABI1	ENSPREP00000011021	ENSPREP00000001513	ENSPREP00000011021	Abl-interactor 1a.	Zgc:158689.	0.423
ABI1	ENSPREP00000013033	ENSPREP00000001513	ENSPREP00000013033	Abl-interactor 1a.	Uncharacterized protein.	0.495
ABI1	ENSPREP00000032937	ENSPREP00000001513	ENSPREP00000032937	Abl-interactor 1a.	SH3 domain-containing protein.	0.625
ABI1	LOC103460840	ENSPREP00000001513	ENSPREP00000013079	Abl-interactor 1a.	Uncharacterized protein; Belongs to the actin family.	0.495
ABI1	LOC103462249	ENSPREP00000001513	ENSPREP00000000029	Abl-interactor 1a.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.797
ABI1	LOC103462254	ENSPREP00000001513	ENSPREP00000000028	Abl-interactor 1a.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.797
ABI1	LOC103463911	ENSPREP00000001513	ENSPREP00000025823	Abl-interactor 1a.	Cytoplasmic FMR1 interacting protein 1.	0.882
ABI1	LOC103465240	ENSPREP00000001513	ENSPREP00000017944	Abl-interactor 1a.	Actin related protein 2/3 complex, subunit 4.	0.456
ABI1	LOC103465991	ENSPREP00000001513	ENSPREP00000020180	Abl-interactor 1a.	WASP like actin nucleation promoting factor a.	0.622
ABI1	LOC103468132	ENSPREP00000001513	ENSPREP00000008546	Abl-interactor 1a.	Zgc:86896.	0.797
ABI1	LOC103468246	ENSPREP00000001513	ENSPREP00000013493	Abl-interactor 1a.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.834
ABI1	LOC103468820	ENSPREP00000001513	ENSPREP00000004709	Abl-interactor 1a.	BAI1-associated protein 2a.	0.714
ABI1	LOC103470899	ENSPREP00000001513	ENSPREP00000030391	Abl-interactor 1a.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.976
ABI1	LOC103475416	ENSPREP00000001513	ENSPREP00000030284	Abl-interactor 1a.	WH2 domain-containing protein.	0.943