STRINGSTRING
LOC103477155 LOC103477155 LOC103476211 LOC103476211 PSPN PSPN Fgf20 Fgf20 fgf8 fgf8 LOC103469672 LOC103469672 plcg2 plcg2 NCSTN NCSTN LOC103472848 LOC103472848 FGF6 FGF6 ENSPREP00000001733 ENSPREP00000001733 LOC103471324 LOC103471324 LOC103475869 LOC103475869 fgf19 fgf19 LOC103462291 LOC103462291 fgf3 fgf3 frs3 frs3 tnfrsf21 tnfrsf21 klb klb ret ret pdgfrb pdgfrb LOC103473467 LOC103473467 Kitlg Kitlg csf1r csf1r LOC103472494 LOC103472494 fgf5 fgf5 LOC103464892 LOC103464892 LOC103472470 LOC103472470 LOC103468819 LOC103468819 ENSPREP00000004603 ENSPREP00000004603 dtx4 dtx4 LOC103459902 LOC103459902 psenen psenen csf1r-2 csf1r-2 frs2 frs2 fgf16 fgf16 ENSPREP00000006768 ENSPREP00000006768 ntrk3 ntrk3 psen2 psen2 ENSPREP00000007409 ENSPREP00000007409 flt4 flt4 fgf1 fgf1 LOC103476019 LOC103476019 fgfr4 fgfr4 LOC103470484 LOC103470484 LOC103471133 LOC103471133 LOC103458160 LOC103458160 LOC103476613 LOC103476613 LOC103471871 LOC103471871 flrt3 flrt3 gfra4 gfra4 ENSPREP00000010497 ENSPREP00000010497 LOC103471859 LOC103471859 pdgfa pdgfa LOC103460077 LOC103460077 bace1 bace1 fgf22 fgf22 LOC103460817 LOC103460817 LOC103479139 LOC103479139 LOC103456886 LOC103456886 fgf7 fgf7 LOC103458271 LOC103458271 LOC103474875 LOC103474875 LOC103463411 LOC103463411 LOC103471632 LOC103471632 ENSPREP00000013954 ENSPREP00000013954 gdf15 gdf15 LOC103477293 LOC103477293 LOC103468250 LOC103468250 LOC103473660 LOC103473660 ngfr ngfr pdgfc pdgfc app app map3k13 map3k13 fgf10 fgf10 FGF13 FGF13 lctl lctl ENSPREP00000015948 ENSPREP00000015948 ydjc ydjc ENSPREP00000016430 ENSPREP00000016430 LOC103468998 LOC103468998 LOC103459420 LOC103459420 LOC103479763 LOC103479763 LOC103464694 LOC103464694 vegfa vegfa ENSPREP00000018426 ENSPREP00000018426 LOC103468941 LOC103468941 gfra2 gfra2 mtpap mtpap tmem104 tmem104 LOC103473157 LOC103473157 LOC103471515 LOC103471515 fgf17 fgf17 gdnf gdnf dok6 dok6 LOC103480434 LOC103480434 Pgf Pgf sh2b3 sh2b3 sort1 sort1 FGFRL1 FGFRL1 LOC103481853 LOC103481853 ENSPREP00000022564 ENSPREP00000022564 ENSPREP00000022877 ENSPREP00000022877 ntf3 ntf3 fgf11 fgf11 ENSPREP00000023045 ENSPREP00000023045 LOC103464855 LOC103464855 sorl1 sorl1 LOC103467541 LOC103467541 LOC103474388 LOC103474388 GGA1 GGA1 ENSPREP00000025004 ENSPREP00000025004 LCT LCT aplp2 aplp2 ENSPREP00000025233 ENSPREP00000025233 mydgf mydgf ntrk1 ntrk1 plcg1 plcg1 mpv17 mpv17 aph1a aph1a ENSPREP00000027807 ENSPREP00000027807 ntrk2 ntrk2 pdgfra pdgfra flt3 flt3 flt1 flt1 kit kit LOC103472703 LOC103472703 LOC103467432 LOC103467432 pir pir vegfd vegfd kdr kdr il34 il34 LOC103476521 LOC103476521 LOC103468546 LOC103468546 LOC103472164 LOC103472164 LOC103478610 LOC103478610 pdgfd pdgfd tbc1d8b tbc1d8b tie1 tie1 cpd cpd ENSPREP00000031993 ENSPREP00000031993 angpt2 angpt2 pdgfrl pdgfrl LOC103470957 LOC103470957 ENSPREP00000032783 ENSPREP00000032783 vegfc vegfc sytl5 sytl5 LOC103459816 LOC103459816 bdnf bdnf gfra1 gfra1 fgf23 fgf23 FGF6-2 FGF6-2 phex phex LOC103481795 LOC103481795
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103477155Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
LOC103476211Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PSPNPersephin. (163 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
LOC103469672Fibroblast growth factor receptor. (831 aa)
plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
NCSTNNicastrin. (699 aa)
LOC103472848Protein kinase domain-containing protein. (536 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
ENSPREP00000001733Uncharacterized protein. (134 aa)
LOC103471324Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC103475869Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
fgf19Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
LOC103462291Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
frs3Fibroblast growth factor receptor substrate 3. (627 aa)
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (690 aa)
klbKlotho beta. (1050 aa)
retProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1040 aa)
LOC103473467Tyrosine-protein kinase receptor. (830 aa)
KitlgKit ligand a. (201 aa)
csf1rUncharacterized protein. (978 aa)
LOC103472494PKD domain-containing protein. (1196 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
LOC103464892Sortilin. (808 aa)
LOC103472470PKD domain-containing protein. (1189 aa)
LOC103468819Apoptosis-associated tyrosine kinase a. (1570 aa)
ENSPREP00000004603Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
dtx4Uncharacterized protein. (808 aa)
LOC103459902Uncharacterized protein. (1039 aa)
psenenUncharacterized protein. (66 aa)
csf1r-2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1041 aa)
frs2Fibroblast growth factor receptor substrate 2b. (521 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
ENSPREP00000006768Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
ntrk3Tyrosine-protein kinase receptor. (815 aa)
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (430 aa)
ENSPREP00000007409NGF domain-containing protein; Belongs to the NGF-beta family. (273 aa)
flt4Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
LOC103476019Fibronectin leucine rich transmembrane protein 1. (727 aa)
fgfr4Fibroblast growth factor receptor 4. (942 aa)
LOC103470484GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (481 aa)
LOC103471133Ig-like domain-containing protein. (335 aa)
LOC103458160Fibroblast growth factor receptor. (814 aa)
LOC103476613GDNF family receptor alpha 1. (516 aa)
LOC103471871Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
flrt3Fibronectin leucine rich transmembrane 3. (650 aa)
gfra4GDNF family receptor alpha 4a. (435 aa)
ENSPREP00000010497Uncharacterized protein; Belongs to the heparin-binding growth factors family. (173 aa)
LOC103471859Fibroblast growth factor binding protein 1b. (202 aa)
pdgfaPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (228 aa)
LOC103460077Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (186 aa)
bace1Beta-secretase 1; Belongs to the peptidase A1 family. (506 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
LOC103460817Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (446 aa)
LOC103479139TGF_BETA_2 domain-containing protein. (295 aa)
LOC103456886Si:ch73-174h16.4. (557 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
LOC103458271Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (388 aa)
LOC103474875Hairy-related 13. (298 aa)
LOC1034634111-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1309 aa)
LOC103471632Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1273 aa)
ENSPREP00000013954Uncharacterized protein. (326 aa)
gdf15TGF_BETA_2 domain-containing protein. (441 aa)
LOC103477293Fibroblast growth factor receptor. (676 aa)
LOC103468250Anosmin 1b. (720 aa)
LOC103473660Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (503 aa)
ngfrNerve growth factor receptor a (TNFR superfamily, member 16). (313 aa)
pdgfcPlatelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (361 aa)
appAmyloid beta (A4) precursor protein a. (338 aa)
map3k13Mitogen-activated protein kinase kinase kinase. (1008 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (606 aa)
ENSPREP00000015948Fibroblast growth factor receptor like 1a. (405 aa)
ydjcYdjC chitooligosaccharide deacetylase homolog. (310 aa)
ENSPREP00000016430Uncharacterized protein. (120 aa)
LOC103468998Uncharacterized protein. (812 aa)
LOC103459420Uncharacterized protein. (253 aa)
LOC103479763Neurturin. (215 aa)
LOC103464694Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (194 aa)
vegfaVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
ENSPREP00000018426Uncharacterized protein. (108 aa)
LOC103468941Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa)
gfra2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (477 aa)
mtpapMitochondrial poly(A) polymerase. (583 aa)
tmem104Transmembrane protein 104. (490 aa)
LOC103473157Fibroblast growth factor receptor. (756 aa)
LOC103471515GDNF family receptor alpha 4b. (427 aa)
fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (229 aa)
dok6Docking protein 6. (424 aa)
LOC103480434Deltex 4, E3 ubiquitin ligase a. (773 aa)
PgfPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (152 aa)
sh2b3SH2B adaptor protein 3. (710 aa)
sort1Sortilin. (822 aa)
FGFRL1Fibroblast growth factor receptor like 1. (478 aa)
LOC103481853Apoptosis-associated tyrosine kinase b. (1652 aa)
ENSPREP00000022564RING-type domain-containing protein. (200 aa)
ENSPREP00000022877Uncharacterized protein. (62 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (304 aa)
fgf11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
ENSPREP00000023045Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (582 aa)
LOC103464855Angiopoietin 4. (503 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats containing. (2086 aa)
LOC103467541Colony stimulating factor 1b (macrophage). (266 aa)
LOC103474388Beta-secretase 2; Belongs to the peptidase A1 family. (508 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (642 aa)
ENSPREP00000025004Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (378 aa)
LCTLactase. (1583 aa)
aplp2Amyloid beta (A4) precursor-like protein 2. (714 aa)
ENSPREP00000025233BPTI/Kunitz inhibitor domain-containing protein. (85 aa)
mydgfMyeloid-derived growth factor. (160 aa)
ntrk1Tyrosine-protein kinase receptor. (797 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1271 aa)
mpv17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (166 aa)
aph1aAPH1B gamma secretase subunit. (258 aa)
ENSPREP00000027807Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
ntrk2Neurotrophic tyrosine kinase, receptor, type 2a. (469 aa)
pdgfraPlatelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1457 aa)
flt3Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (332 aa)
flt1Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1274 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
LOC103472703EF-hand domain-containing protein. (86 aa)
LOC103467432Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (286 aa)
pirPirin; Belongs to the pirin family. (313 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (286 aa)
kdrKinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1357 aa)
il34Interleukin 34. (223 aa)
LOC103476521Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
LOC103468546PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
LOC103472164Angiopoietin 2b. (501 aa)
LOC103478610Neurotrophin receptor associated death domain. (404 aa)
pdgfdPlatelet derived growth factor d. (359 aa)
tbc1d8bTBC1 domain family member 8B. (1030 aa)
tie1Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1138 aa)
cpdCarboxypeptidase D, a. (1389 aa)
ENSPREP00000031993Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (131 aa)
angpt2Angiopoietin 2a. (491 aa)
pdgfrlPlatelet-derived growth factor receptor-like. (433 aa)
LOC103470957Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENSPREP00000032783Uncharacterized protein. (313 aa)
vegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (420 aa)
sytl5Synaptotagmin-like 5. (751 aa)
LOC103459816Amyloid beta (A4) precursor protein b. (751 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (294 aa)
gfra1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (469 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
phexPhosphate regulating endopeptidase homolog, X-linked. (690 aa)
LOC103481795Nerve growth factor receptor b. (354 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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