(26 nodes) Phospholipase C-mediated cascade; FGFR2, and Fibroblast growth factor receptor activity network (Poecilia reticulata)

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	LOC103471324	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC103459902	Uncharacterized protein. (1039 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	LOC103458160	Fibroblast growth factor receptor. (814 aa)
	LOC103471871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	LOC103463411	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1309 aa)
	LOC103477293	Fibroblast growth factor receptor. (676 aa)
	LOC103473660	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (503 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	ENSPREP00000015948	Fibroblast growth factor receptor like 1a. (405 aa)
	LOC103473157	Fibroblast growth factor receptor. (756 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1271 aa)
	ntrk2	Neurotrophic tyrosine kinase, receptor, type 2a. (469 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1457 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1357 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103470957	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000015948	LOC103462291	ENSPREP00000015948	ENSPREP00000002555	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.538
ENSPREP00000015948	LOC103463411	ENSPREP00000015948	ENSPREP00000013501	Fibroblast growth factor receptor like 1a.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.547
ENSPREP00000015948	LOC103470957	ENSPREP00000015948	ENSPREP00000032721	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.556
ENSPREP00000015948	LOC103471324	ENSPREP00000015948	ENSPREP00000002038	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.616
ENSPREP00000015948	LOC103471871	ENSPREP00000015948	ENSPREP00000009989	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.616
ENSPREP00000015948	LOC103473660	ENSPREP00000015948	ENSPREP00000014108	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.602
ENSPREP00000015948	LOC103476521	ENSPREP00000015948	ENSPREP00000029747	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.794
ENSPREP00000015948	fgf1	ENSPREP00000015948	ENSPREP00000007991	Fibroblast growth factor receptor like 1a.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.581
ENSPREP00000015948	fgf10	ENSPREP00000015948	ENSPREP00000014875	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.602
ENSPREP00000015948	fgf16	ENSPREP00000015948	ENSPREP00000006553	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.556
ENSPREP00000015948	fgf17	ENSPREP00000015948	ENSPREP00000019823	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.645
ENSPREP00000015948	fgf19	ENSPREP00000015948	ENSPREP00000002527	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.599
ENSPREP00000015948	fgf22	ENSPREP00000015948	ENSPREP00000011331	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.602
ENSPREP00000015948	fgf23	ENSPREP00000015948	ENSPREP00000033759	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.736
ENSPREP00000015948	fgf3	ENSPREP00000015948	ENSPREP00000002583	Fibroblast growth factor receptor like 1a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.686
ENSPREP00000015948	plcg1	ENSPREP00000015948	ENSPREP00000027159	Fibroblast growth factor receptor like 1a.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.547
ENSPREP00000015948	plcg2	ENSPREP00000015948	ENSPREP00000001068	Fibroblast growth factor receptor like 1a.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.547
LOC103458160	LOC103462291	ENSPREP00000009232	ENSPREP00000002555	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.785
LOC103458160	LOC103463411	ENSPREP00000009232	ENSPREP00000013501	Fibroblast growth factor receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.581
LOC103458160	LOC103470957	ENSPREP00000009232	ENSPREP00000032721	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.854