(5 nodes) FOXO protein, KIX-binding domain, and rDNA heterochromatin network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sirt1	Sirtuin 1. (677 aa)
	foxo3	Forkhead box O3b. (644 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC103471967	Forkhead box O6 b. (743 aa)
	LOC103458349	Fork-head domain-containing protein. (604 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103458349	LOC103471967	ENSPREP00000024684	ENSPREP00000020462	Fork-head domain-containing protein.	Forkhead box O6 b.	0.905
LOC103458349	LOC103476681	ENSPREP00000024684	ENSPREP00000012589	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
LOC103458349	foxo3	ENSPREP00000024684	ENSPREP00000007444	Fork-head domain-containing protein.	Forkhead box O3b.	0.902
LOC103458349	sirt1	ENSPREP00000024684	ENSPREP00000003960	Fork-head domain-containing protein.	Sirtuin 1.	0.986
LOC103471967	LOC103458349	ENSPREP00000020462	ENSPREP00000024684	Forkhead box O6 b.	Fork-head domain-containing protein.	0.905
LOC103471967	LOC103476681	ENSPREP00000020462	ENSPREP00000012589	Forkhead box O6 b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.933
LOC103471967	foxo3	ENSPREP00000020462	ENSPREP00000007444	Forkhead box O6 b.	Forkhead box O3b.	0.910
LOC103471967	sirt1	ENSPREP00000020462	ENSPREP00000003960	Forkhead box O6 b.	Sirtuin 1.	0.934
LOC103476681	LOC103458349	ENSPREP00000012589	ENSPREP00000024684	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.971
LOC103476681	LOC103471967	ENSPREP00000012589	ENSPREP00000020462	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O6 b.	0.933
LOC103476681	foxo3	ENSPREP00000012589	ENSPREP00000007444	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3b.	0.971
foxo3	LOC103458349	ENSPREP00000007444	ENSPREP00000024684	Forkhead box O3b.	Fork-head domain-containing protein.	0.902
foxo3	LOC103471967	ENSPREP00000007444	ENSPREP00000020462	Forkhead box O3b.	Forkhead box O6 b.	0.910
foxo3	LOC103476681	ENSPREP00000007444	ENSPREP00000012589	Forkhead box O3b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
foxo3	sirt1	ENSPREP00000007444	ENSPREP00000003960	Forkhead box O3b.	Sirtuin 1.	0.986
sirt1	LOC103458349	ENSPREP00000003960	ENSPREP00000024684	Sirtuin 1.	Fork-head domain-containing protein.	0.986
sirt1	LOC103471967	ENSPREP00000003960	ENSPREP00000020462	Sirtuin 1.	Forkhead box O6 b.	0.934
sirt1	foxo3	ENSPREP00000003960	ENSPREP00000007444	Sirtuin 1.	Forkhead box O3b.	0.986