(31 nodes) Mixed, incl. RIP-mediated NFkB activation via ZBP1, and NIK/NF-kappaB signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	relb	V-rel avian reticuloendotheliosis viral oncogene homolog B. (579 aa)
	LOC103478932	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (389 aa)
	LOC103466618	MALT paracaspase 3. (573 aa)
	LOC103469935	MALT paracaspase 1. (828 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	nfkbie	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (343 aa)
	LOC103481612	ADP-ribosylation factor 2b. (786 aa)
	LOC103468661	Mitogen-activated protein kinase kinase kinase 14a. (869 aa)
	ENSPREP00000013883	Uncharacterized protein. (211 aa)
	rel	REL proto-oncogene, NF-kB subunit. (642 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (803 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	prkcd	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (664 aa)
	ENSPREP00000018398	MALT paracaspase 2. (715 aa)
	ENSPREP00000018835	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (895 aa)
	map3k8	Mitogen-activated protein kinase kinase kinase 8. (468 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (772 aa)
	ENSPREP00000020807	Uncharacterized protein. (380 aa)
	ENSPREP00000020918	Uncharacterized protein. (245 aa)
	bcl3	BCL3 transcription coactivator. (494 aa)
	ENSPREP00000023044	C2 domain-containing protein. (126 aa)
	prkch	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (553 aa)
	LOC103470783	CARD domain-containing protein. (434 aa)
	LOC103465056	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	LOC103457805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	setd6	N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (447 aa)
	LOC103476976	Component of inhibitor of nuclear factor kappa B kinase complex. (689 aa)
	LOC103480184	V-rel avian reticuloendotheliosis viral oncogene homolog A. (627 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPREP00000013883	ENSPREP00000020163	ENSPREP00000013883	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.604
CHUK	ENSPREP00000018398	ENSPREP00000020163	ENSPREP00000018398	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 2.	0.472
CHUK	ENSPREP00000018835	ENSPREP00000020163	ENSPREP00000018835	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.644
CHUK	ENSPREP00000020807	ENSPREP00000020163	ENSPREP00000020807	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.604
CHUK	ENSPREP00000020918	ENSPREP00000020163	ENSPREP00000020918	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.604
CHUK	ENSPREP00000027430	ENSPREP00000020163	ENSPREP00000027430	Component of inhibitor of nuclear factor kappa B kinase complex.	CARD domain-containing protein.	0.569
CHUK	LOC103457805	ENSPREP00000020163	ENSPREP00000027480	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC103466618	ENSPREP00000020163	ENSPREP00000011487	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.944
CHUK	LOC103468544	ENSPREP00000020163	ENSPREP00000027446	Component of inhibitor of nuclear factor kappa B kinase complex.	Guanylate kinase-like domain-containing protein.	0.569
CHUK	LOC103468661	ENSPREP00000020163	ENSPREP00000013046	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 14a.	0.973
CHUK	LOC103469935	ENSPREP00000020163	ENSPREP00000011835	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 1.	0.944
CHUK	LOC103476976	ENSPREP00000020163	ENSPREP00000032137	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943
CHUK	LOC103480184	ENSPREP00000020163	ENSPREP00000032422	Component of inhibitor of nuclear factor kappa B kinase complex.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.674
CHUK	LOC103481612	ENSPREP00000020163	ENSPREP00000012735	Component of inhibitor of nuclear factor kappa B kinase complex.	ADP-ribosylation factor 2b.	0.973
CHUK	NFKB1	ENSPREP00000020163	ENSPREP00000016386	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor kappa B subunit 1.	0.606
CHUK	bcl3	ENSPREP00000020163	ENSPREP00000022380	Component of inhibitor of nuclear factor kappa B kinase complex.	BCL3 transcription coactivator.	0.604
CHUK	ikbkb	ENSPREP00000020163	ENSPREP00000016563	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.950
CHUK	map3k8	ENSPREP00000020163	ENSPREP00000019197	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 8.	0.927
CHUK	nfkbia	ENSPREP00000020163	ENSPREP00000012072	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.958
CHUK	nfkbie	ENSPREP00000020163	ENSPREP00000012401	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon.	0.958