(6 nodes) IRF3-mediated induction of type I IFN, and TICAM1-dependent activation of IRF3/IRF7 network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	tlr3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (924 aa)
	sting1	Transmembrane protein 173. (484 aa)
	LOC103479366	TRIF-NTD domain-containing protein. (564 aa)
	tbk1	TANK-binding kinase 1. (703 aa)
	irf7	Interferon regulatory factor 7. (472 aa)
	LOC103481249	Interferon regulatory factor 3. (465 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103479366	LOC103481249	ENSPREP00000023695	ENSPREP00000032515	TRIF-NTD domain-containing protein.	Interferon regulatory factor 3.	0.974
LOC103479366	irf7	ENSPREP00000023695	ENSPREP00000028492	TRIF-NTD domain-containing protein.	Interferon regulatory factor 7.	0.949
LOC103479366	tbk1	ENSPREP00000023695	ENSPREP00000027853	TRIF-NTD domain-containing protein.	TANK-binding kinase 1.	0.667
LOC103479366	tlr3	ENSPREP00000023695	ENSPREP00000000080	TRIF-NTD domain-containing protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.949
LOC103481249	LOC103479366	ENSPREP00000032515	ENSPREP00000023695	Interferon regulatory factor 3.	TRIF-NTD domain-containing protein.	0.974
LOC103481249	irf7	ENSPREP00000032515	ENSPREP00000028492	Interferon regulatory factor 3.	Interferon regulatory factor 7.	0.984
LOC103481249	sting1	ENSPREP00000032515	ENSPREP00000006284	Interferon regulatory factor 3.	Transmembrane protein 173.	0.975
LOC103481249	tbk1	ENSPREP00000032515	ENSPREP00000027853	Interferon regulatory factor 3.	TANK-binding kinase 1.	0.993
LOC103481249	tlr3	ENSPREP00000032515	ENSPREP00000000080	Interferon regulatory factor 3.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.573
irf7	LOC103479366	ENSPREP00000028492	ENSPREP00000023695	Interferon regulatory factor 7.	TRIF-NTD domain-containing protein.	0.949
irf7	LOC103481249	ENSPREP00000028492	ENSPREP00000032515	Interferon regulatory factor 7.	Interferon regulatory factor 3.	0.984
irf7	sting1	ENSPREP00000028492	ENSPREP00000006284	Interferon regulatory factor 7.	Transmembrane protein 173.	0.625
irf7	tbk1	ENSPREP00000028492	ENSPREP00000027853	Interferon regulatory factor 7.	TANK-binding kinase 1.	0.974
irf7	tlr3	ENSPREP00000028492	ENSPREP00000000080	Interferon regulatory factor 7.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.670
sting1	LOC103481249	ENSPREP00000006284	ENSPREP00000032515	Transmembrane protein 173.	Interferon regulatory factor 3.	0.975
sting1	irf7	ENSPREP00000006284	ENSPREP00000028492	Transmembrane protein 173.	Interferon regulatory factor 7.	0.625
sting1	tbk1	ENSPREP00000006284	ENSPREP00000027853	Transmembrane protein 173.	TANK-binding kinase 1.	0.995
tbk1	LOC103479366	ENSPREP00000027853	ENSPREP00000023695	TANK-binding kinase 1.	TRIF-NTD domain-containing protein.	0.667
tbk1	LOC103481249	ENSPREP00000027853	ENSPREP00000032515	TANK-binding kinase 1.	Interferon regulatory factor 3.	0.993
tbk1	irf7	ENSPREP00000027853	ENSPREP00000028492	TANK-binding kinase 1.	Interferon regulatory factor 7.	0.974