(10 nodes) Phase 1 - inactivation of fast Na+ channels, and LETM1/MDM38-like network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kcnip2	Kv channel interacting protein 2. (229 aa)
	LOC103475897	Uncharacterized protein. (184 aa)
	ENSPREP00000010417	Uncharacterized protein. (55 aa)
	KCND3	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (677 aa)
	LOC103473704	Kv channel interacting protein 3b, calsenilin. (256 aa)
	LOC103470046	Leucine zipper-EF-hand containing transmembrane protein 2. (514 aa)
	KCNIP3	Potassium voltage-gated channel interacting protein 3. (351 aa)
	LOC103467453	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (645 aa)
	kcnd2	Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family. (614 aa)
	dpp6	Dipeptidyl-peptidase 6a; Belongs to the peptidase S9B family. (847 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010417	KCND3	ENSPREP00000010417	ENSPREP00000013518	Uncharacterized protein.	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	0.427
ENSPREP00000010417	LOC103467453	ENSPREP00000010417	ENSPREP00000027891	Uncharacterized protein.	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	0.427
ENSPREP00000010417	kcnd2	ENSPREP00000010417	ENSPREP00000028011	Uncharacterized protein.	Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family.	0.427
ENSPREP00000010417	kcnip2	ENSPREP00000010417	ENSPREP00000000598	Uncharacterized protein.	Kv channel interacting protein 2.	0.405
KCND3	ENSPREP00000010417	ENSPREP00000013518	ENSPREP00000010417	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	Uncharacterized protein.	0.427
KCND3	KCNIP3	ENSPREP00000013518	ENSPREP00000017983	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	Potassium voltage-gated channel interacting protein 3.	0.575
KCND3	LOC103473704	ENSPREP00000013518	ENSPREP00000016229	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	Kv channel interacting protein 3b, calsenilin.	0.575
KCND3	LOC103475897	ENSPREP00000013518	ENSPREP00000002200	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	Uncharacterized protein.	0.575
KCND3	kcnip2	ENSPREP00000013518	ENSPREP00000000598	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	Kv channel interacting protein 2.	0.575
KCNIP3	KCND3	ENSPREP00000017983	ENSPREP00000013518	Potassium voltage-gated channel interacting protein 3.	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	0.575
KCNIP3	LOC103467453	ENSPREP00000017983	ENSPREP00000027891	Potassium voltage-gated channel interacting protein 3.	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	0.575
KCNIP3	LOC103470046	ENSPREP00000017983	ENSPREP00000017680	Potassium voltage-gated channel interacting protein 3.	Leucine zipper-EF-hand containing transmembrane protein 2.	0.681
KCNIP3	kcnd2	ENSPREP00000017983	ENSPREP00000028011	Potassium voltage-gated channel interacting protein 3.	Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family.	0.575
LOC103467453	ENSPREP00000010417	ENSPREP00000027891	ENSPREP00000010417	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	Uncharacterized protein.	0.427
LOC103467453	KCNIP3	ENSPREP00000027891	ENSPREP00000017983	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	Potassium voltage-gated channel interacting protein 3.	0.575
LOC103467453	LOC103473704	ENSPREP00000027891	ENSPREP00000016229	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	Kv channel interacting protein 3b, calsenilin.	0.575
LOC103467453	LOC103475897	ENSPREP00000027891	ENSPREP00000002200	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	Uncharacterized protein.	0.575
LOC103467453	kcnip2	ENSPREP00000027891	ENSPREP00000000598	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.	Kv channel interacting protein 2.	0.575
LOC103470046	KCNIP3	ENSPREP00000017680	ENSPREP00000017983	Leucine zipper-EF-hand containing transmembrane protein 2.	Potassium voltage-gated channel interacting protein 3.	0.681
LOC103470046	LOC103473704	ENSPREP00000017680	ENSPREP00000016229	Leucine zipper-EF-hand containing transmembrane protein 2.	Kv channel interacting protein 3b, calsenilin.	0.681