(62 nodes) Spliceosomal complex, and Alternative mRNA splicing, via spliceosome network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	plrg1	Pleiotropic regulator 1. (510 aa)
	LOC103465396	Si:dkey-93h22.8. (1053 aa)
	LOC103464681	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (651 aa)
	ppie	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
	tfip11	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family. (830 aa)
	ppil1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	cdc40	Cell division cycle 40 homolog (S. cerevisiae). (581 aa)
	prpf19	Pre-mRNA processing factor 19. (458 aa)
	LOC103467951	G patch domain and KOW motifs. (323 aa)
	srrm1	Serine/arginine repetitive matrix 1. (839 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1057 aa)
	syf2	SYF2 pre-mRNA-splicing factor. (238 aa)
	dhx29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1373 aa)
	ENSPREP00000004346	Uncharacterized protein. (56 aa)
	Rbmx2	Uncharacterized protein. (221 aa)
	dhx16	DEAH (Asp-Glu-Ala-His) box polypeptide 16. (1052 aa)
	rbm22	RNA binding motif protein 22. (426 aa)
	Cwc25	Cir_N domain-containing protein. (64 aa)
	cwc22	CWC22 spliceosome associated protein homolog. (854 aa)
	slu7	SLU7 homolog, splicing factor. (560 aa)
	cdc5l	CDC5 cell division cycle 5-like (S. pombe). (809 aa)
	LOC103460651	Cwf21 domain-containing protein. (965 aa)
	zcchc17	Zinc finger, CCHC domain containing 17. (304 aa)
	DDX41	DEAD-box helicase 41. (614 aa)
	ppil3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (158 aa)
	xab2	XPA binding protein 2. (912 aa)
	snip1	Smad nuclear interacting protein. (363 aa)
	parpbp	PARP1 binding protein. (589 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1325 aa)
	SRRM3	Serine/arginine repetitive matrix 3. (640 aa)
	dhx33	DEAH (Asp-Glu-Ala-His) box polypeptide 33. (682 aa)
	ZNF830	Zinc finger protein 830. (333 aa)
	bcas2	BCAS2 pre-mRNA processing factor. (243 aa)
	rnf113a	Ring finger protein 113A. (323 aa)
	LOC103458447	Src homology 2 domain containing transforming protein D, a. (415 aa)
	yju2	YJU2 splicing factor homolog. (344 aa)
	ctnnbl1	Catenin, beta like 1. (534 aa)
	dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8. (1258 aa)
	crnkl1	Crooked neck pre-mRNA splicing factor 1. (749 aa)
	ppil2	Peptidylprolyl isomerase (cyclophilin)-like 2. (525 aa)
	WDR70	WD repeat domain 70. (536 aa)
	LOC103460347	ISY1 splicing factor homolog. (235 aa)
	prpf18	PRP18 pre-mRNA processing factor 18 homolog (yeast). (341 aa)
	LOC103468401	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (636 aa)
	wbp11	WW domain binding protein 11. (696 aa)
	dhx34	DEAH (Asp-Glu-Ala-His) box polypeptide 34. (1137 aa)
	ENSPREP00000025430	BUD13 homolog. (482 aa)
	bud31	BUD31 homolog. (103 aa)
	dhx35	DEAH-box helicase 35. (699 aa)
	snw1	SNW domain containing 1. (536 aa)
	cwc27	CWC27 spliceosome associated cyclophilin. (455 aa)
	ppwd1	Peptidylprolyl isomerase domain and WD repeat containing 1. (632 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (636 aa)
	LOC103480693	DEAH (Asp-Glu-Ala-His) box helicase 15. (729 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1216 aa)
	ENSPREP00000029432	Uncharacterized protein. (223 aa)
	wdr25	WD_REPEATS_REGION domain-containing protein. (228 aa)
	pprc1	PPARG related coactivator 1. (1131 aa)
	ccdc12	Coiled-coil domain containing 12. (202 aa)
	cwf19l2	CWF19 like cell cycle control factor 2. (774 aa)
	cwc15	CWC15 spliceosome associated protein homolog. (238 aa)
	dhx38	DEAH (Asp-Glu-Ala-His) box polypeptide 38. (1229 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cwc25	DDX41	ENSPREP00000005308	ENSPREP00000007803	Cir_N domain-containing protein.	DEAD-box helicase 41.	0.641
Cwc25	DDX5	ENSPREP00000005308	ENSPREP00000027962	Cir_N domain-containing protein.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.663
Cwc25	ENSPREP00000004346	ENSPREP00000005308	ENSPREP00000004346	Cir_N domain-containing protein.	Uncharacterized protein.	0.511
Cwc25	ENSPREP00000025430	ENSPREP00000005308	ENSPREP00000025430	Cir_N domain-containing protein.	BUD13 homolog.	0.804
Cwc25	ENSPREP00000029432	ENSPREP00000005308	ENSPREP00000029432	Cir_N domain-containing protein.	Uncharacterized protein.	0.951
Cwc25	LOC103458447	ENSPREP00000005308	ENSPREP00000015749	Cir_N domain-containing protein.	Src homology 2 domain containing transforming protein D, a.	0.990
Cwc25	LOC103460347	ENSPREP00000005308	ENSPREP00000022403	Cir_N domain-containing protein.	ISY1 splicing factor homolog.	0.958
Cwc25	LOC103460651	ENSPREP00000005308	ENSPREP00000007743	Cir_N domain-containing protein.	Cwf21 domain-containing protein.	0.960
Cwc25	LOC103464681	ENSPREP00000005308	ENSPREP00000000681	Cir_N domain-containing protein.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.663
Cwc25	LOC103465396	ENSPREP00000005308	ENSPREP00000000591	Cir_N domain-containing protein.	Si:dkey-93h22.8.	0.699
Cwc25	LOC103467951	ENSPREP00000005308	ENSPREP00000003710	Cir_N domain-containing protein.	G patch domain and KOW motifs.	0.581
Cwc25	LOC103468401	ENSPREP00000005308	ENSPREP00000022845	Cir_N domain-containing protein.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.663
Cwc25	LOC103480693	ENSPREP00000005308	ENSPREP00000028442	Cir_N domain-containing protein.	DEAH (Asp-Glu-Ala-His) box helicase 15.	0.784
Cwc25	Rbmx2	ENSPREP00000005308	ENSPREP00000004358	Cir_N domain-containing protein.	Uncharacterized protein.	0.511
Cwc25	SRRM3	ENSPREP00000005308	ENSPREP00000011967	Cir_N domain-containing protein.	Serine/arginine repetitive matrix 3.	0.950
Cwc25	WDR70	ENSPREP00000005308	ENSPREP00000020025	Cir_N domain-containing protein.	WD repeat domain 70.	0.840
Cwc25	aqr	ENSPREP00000005308	ENSPREP00000010608	Cir_N domain-containing protein.	Aquarius intron-binding spliceosomal factor.	0.570
Cwc25	bcas2	ENSPREP00000005308	ENSPREP00000014327	Cir_N domain-containing protein.	BCAS2 pre-mRNA processing factor.	0.567
Cwc25	bud31	ENSPREP00000005308	ENSPREP00000026818	Cir_N domain-containing protein.	BUD31 homolog.	0.990
Cwc25	cdc40	ENSPREP00000005308	ENSPREP00000003161	Cir_N domain-containing protein.	Cell division cycle 40 homolog (S. cerevisiae).	0.996