(20 nodes) U2-type catalytic step 2 spliceosome, and Spliceosomal conformational changes to generate catalytic conformation network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ppie	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
	cdc40	Cell division cycle 40 homolog (S. cerevisiae). (581 aa)
	syf2	SYF2 pre-mRNA-splicing factor. (238 aa)
	rbm22	RNA binding motif protein 22. (426 aa)
	Cwc25	Cir_N domain-containing protein. (64 aa)
	cwc22	CWC22 spliceosome associated protein homolog. (854 aa)
	slu7	SLU7 homolog, splicing factor. (560 aa)
	xab2	XPA binding protein 2. (912 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1325 aa)
	SRRM3	Serine/arginine repetitive matrix 3. (640 aa)
	ZNF830	Zinc finger protein 830. (333 aa)
	yju2	YJU2 splicing factor homolog. (344 aa)
	crnkl1	Crooked neck pre-mRNA splicing factor 1. (749 aa)
	LOC103460347	ISY1 splicing factor homolog. (235 aa)
	prpf18	PRP18 pre-mRNA processing factor 18 homolog (yeast). (341 aa)
	dhx34	DEAH (Asp-Glu-Ala-His) box polypeptide 34. (1137 aa)
	bud31	BUD31 homolog. (103 aa)
	dhx35	DEAH-box helicase 35. (699 aa)
	snw1	SNW domain containing 1. (536 aa)
	dhx38	DEAH (Asp-Glu-Ala-His) box polypeptide 38. (1229 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cwc25	LOC103460347	ENSPREP00000005308	ENSPREP00000022403	Cir_N domain-containing protein.	ISY1 splicing factor homolog.	0.958
Cwc25	SRRM3	ENSPREP00000005308	ENSPREP00000011967	Cir_N domain-containing protein.	Serine/arginine repetitive matrix 3.	0.950
Cwc25	aqr	ENSPREP00000005308	ENSPREP00000010608	Cir_N domain-containing protein.	Aquarius intron-binding spliceosomal factor.	0.570
Cwc25	bud31	ENSPREP00000005308	ENSPREP00000026818	Cir_N domain-containing protein.	BUD31 homolog.	0.990
Cwc25	cdc40	ENSPREP00000005308	ENSPREP00000003161	Cir_N domain-containing protein.	Cell division cycle 40 homolog (S. cerevisiae).	0.996
Cwc25	crnkl1	ENSPREP00000005308	ENSPREP00000018631	Cir_N domain-containing protein.	Crooked neck pre-mRNA splicing factor 1.	0.944
Cwc25	cwc22	ENSPREP00000005308	ENSPREP00000006247	Cir_N domain-containing protein.	CWC22 spliceosome associated protein homolog.	0.985
Cwc25	dhx34	ENSPREP00000005308	ENSPREP00000024312	Cir_N domain-containing protein.	DEAH (Asp-Glu-Ala-His) box polypeptide 34.	0.837
Cwc25	dhx35	ENSPREP00000005308	ENSPREP00000026925	Cir_N domain-containing protein.	DEAH-box helicase 35.	0.838
Cwc25	dhx38	ENSPREP00000005308	ENSPREP00000034266	Cir_N domain-containing protein.	DEAH (Asp-Glu-Ala-His) box polypeptide 38.	0.997
Cwc25	ppie	ENSPREP00000005308	ENSPREP00000002091	Cir_N domain-containing protein.	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.	0.765
Cwc25	prpf18	ENSPREP00000005308	ENSPREP00000022575	Cir_N domain-containing protein.	PRP18 pre-mRNA processing factor 18 homolog (yeast).	0.933
Cwc25	rbm22	ENSPREP00000005308	ENSPREP00000005089	Cir_N domain-containing protein.	RNA binding motif protein 22.	0.920
Cwc25	slu7	ENSPREP00000005308	ENSPREP00000006292	Cir_N domain-containing protein.	SLU7 homolog, splicing factor.	0.946
Cwc25	snw1	ENSPREP00000005308	ENSPREP00000027074	Cir_N domain-containing protein.	SNW domain containing 1.	0.945
Cwc25	syf2	ENSPREP00000005308	ENSPREP00000004254	Cir_N domain-containing protein.	SYF2 pre-mRNA-splicing factor.	0.980
Cwc25	xab2	ENSPREP00000005308	ENSPREP00000008611	Cir_N domain-containing protein.	XPA binding protein 2.	0.944
Cwc25	yju2	ENSPREP00000005308	ENSPREP00000015829	Cir_N domain-containing protein.	YJU2 splicing factor homolog.	0.994
LOC103460347	Cwc25	ENSPREP00000022403	ENSPREP00000005308	ISY1 splicing factor homolog.	Cir_N domain-containing protein.	0.958
LOC103460347	SRRM3	ENSPREP00000022403	ENSPREP00000011967	ISY1 splicing factor homolog.	Serine/arginine repetitive matrix 3.	0.922