(30 nodes) Wnt signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	ENSPREP00000005844	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	ENSPREP00000015698	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	LOC103462771	Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (776 aa)
	ENSPREP00000017223	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (546 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa)
	sfrp1	Secreted frizzled-related protein 1a. (305 aa)
	ryk	Receptor like tyrosine kinase. (632 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
	ENSPREP00000025759	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (735 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	sfrp5	Secreted frizzled-related protein 5. (323 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103467401	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (953 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005844	ENSPREP00000025759	ENSPREP00000005844	ENSPREP00000025759	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.804
ENSPREP00000005844	LOC103459284	ENSPREP00000005844	ENSPREP00000006858	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.878
ENSPREP00000005844	LOC103467401	ENSPREP00000005844	ENSPREP00000029660	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.804
ENSPREP00000005844	LOC103467447	ENSPREP00000005844	ENSPREP00000028159	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.894
ENSPREP00000005844	LOC103474475	ENSPREP00000005844	ENSPREP00000028750	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.673
ENSPREP00000005844	WNT7A	ENSPREP00000005844	ENSPREP00000030519	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.806
ENSPREP00000005844	Wnt16	ENSPREP00000005844	ENSPREP00000028089	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.811
ENSPREP00000005844	fzd4	ENSPREP00000005844	ENSPREP00000030507	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.426
ENSPREP00000005844	ror1	ENSPREP00000005844	ENSPREP00000030444	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.952
ENSPREP00000005844	ryk	ENSPREP00000005844	ENSPREP00000022759	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.927
ENSPREP00000005844	sfrp1	ENSPREP00000005844	ENSPREP00000022052	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.674
ENSPREP00000005844	sfrp2	ENSPREP00000005844	ENSPREP00000000067	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.673
ENSPREP00000005844	sfrp5	ENSPREP00000005844	ENSPREP00000028596	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.668
ENSPREP00000005844	wnt1	ENSPREP00000005844	ENSPREP00000031027	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.837
ENSPREP00000005844	wnt11	ENSPREP00000005844	ENSPREP00000014718	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.968
ENSPREP00000005844	wnt2	ENSPREP00000005844	ENSPREP00000003715	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.815
ENSPREP00000005844	wnt2b	ENSPREP00000005844	ENSPREP00000013643	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.804
ENSPREP00000005844	wnt3	ENSPREP00000005844	ENSPREP00000017531	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.904
ENSPREP00000005844	wnt3a	ENSPREP00000005844	ENSPREP00000011284	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.930
ENSPREP00000005844	wnt4	ENSPREP00000005844	ENSPREP00000026620	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.837