(6 nodes) Mixed, incl. Fourth ventricle development, and Frizzled/Smoothened family membrane region network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	sfrp1	Secreted frizzled-related protein 1a. (305 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (735 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fzd10	fzd3	ENSPREP00000002813	ENSPREP00000028048	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.413
fzd10	sfrp1	ENSPREP00000002813	ENSPREP00000022052	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.671
fzd10	wnt1	ENSPREP00000002813	ENSPREP00000031027	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.861
fzd10	wnt4	ENSPREP00000002813	ENSPREP00000026620	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.840
fzd10	wnt6	ENSPREP00000002813	ENSPREP00000023102	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.835
fzd3	fzd10	ENSPREP00000028048	ENSPREP00000002813	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.413
fzd3	sfrp1	ENSPREP00000028048	ENSPREP00000022052	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.739
fzd3	wnt1	ENSPREP00000028048	ENSPREP00000031027	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.873
fzd3	wnt4	ENSPREP00000028048	ENSPREP00000026620	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.898
fzd3	wnt6	ENSPREP00000028048	ENSPREP00000023102	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.826
sfrp1	fzd10	ENSPREP00000022052	ENSPREP00000002813	Secreted frizzled-related protein 1a.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.671
sfrp1	fzd3	ENSPREP00000022052	ENSPREP00000028048	Secreted frizzled-related protein 1a.	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.739
sfrp1	wnt1	ENSPREP00000022052	ENSPREP00000031027	Secreted frizzled-related protein 1a.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.876
sfrp1	wnt4	ENSPREP00000022052	ENSPREP00000026620	Secreted frizzled-related protein 1a.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.853
sfrp1	wnt6	ENSPREP00000022052	ENSPREP00000023102	Secreted frizzled-related protein 1a.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.818
wnt1	fzd10	ENSPREP00000031027	ENSPREP00000002813	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.861
wnt1	fzd3	ENSPREP00000031027	ENSPREP00000028048	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.873
wnt1	sfrp1	ENSPREP00000031027	ENSPREP00000022052	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 1a.	0.876
wnt1	wnt4	ENSPREP00000031027	ENSPREP00000026620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.652
wnt1	wnt6	ENSPREP00000031027	ENSPREP00000023102	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.667