(83 nodes) Mixed, incl. Nuclear hormone receptor, and PAS fold network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ncor2	Nuclear receptor corepressor 2. (2291 aa)
	LOC103466861	Uncharacterized protein. (420 aa)
	LOC103464934	Vitamin D receptor b. (425 aa)
	LOC103477707	Nuclear receptor subfamily 1, group D, member 2a. (544 aa)
	maml3	Mastermind-like transcriptional coactivator 3. (1158 aa)
	LOC103458082	Estrogen receptor 2b. (664 aa)
	LOC103478548	Retinoid x receptor, beta b. (412 aa)
	LOC103459232	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (405 aa)
	NPAS3	Neuronal PAS domain protein 3. (1062 aa)
	egln3	Egl-9 family hypoxia-inducible factor 3. (266 aa)
	nrf1	Nuclear respiratory factor 1. (525 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	foxa1	Fork-head domain-containing protein. (411 aa)
	LOC103462195	Homeobox containing 1a. (378 aa)
	LOC108166993	Uncharacterized protein. (117 aa)
	ENSPREP00000009170	Endothelial PAS domain protein 1b. (814 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (474 aa)
	RXRB	Retinoid X receptor beta. (417 aa)
	kat2b	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (798 aa)
	LOC103460055	Uncharacterized protein. (464 aa)
	NCOA3	Nuclear receptor coactivator. (1429 aa)
	carm1	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (582 aa)
	ENSPREP00000011180	Nuclear receptor subfamily 5, group A, member 2. (465 aa)
	crebbp	CREB binding protein b. (2452 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (307 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (929 aa)
	sp1	Sp1 transcription factor. (593 aa)
	egln1	Egl-9 family hypoxia-inducible factor 1a. (360 aa)
	ENSPREP00000012571	BHLH domain-containing protein. (68 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (260 aa)
	npas4	Neuronal PAS domain protein 4a. (940 aa)
	ESRRB	Estrogen-related receptor beta. (477 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (472 aa)
	Hnf1b	HNF1 homeobox Ba. (422 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (797 aa)
	nrip1	Nuclear receptor interacting protein 1b. (1200 aa)
	LOC103463575	Uncharacterized protein. (438 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	LOC103471778	ATP binding cassette subfamily A member 1. (2155 aa)
	LOC103473114	Uncharacterized protein. (439 aa)
	ENSPREP00000017463	Uncharacterized protein. (388 aa)
	LOC103462767	Estrogen-related receptor gamma a. (557 aa)
	esrra	Estrogen-related receptor alpha. (433 aa)
	THRA	Thyroid hormone receptor alpha. (413 aa)
	LOC103480487	Plac8 onzin related protein 1. (128 aa)
	GATA2	GATA binding protein 2. (462 aa)
	LOC103479274	RAR-related orphan receptor C b. (500 aa)
	LOC103464167	Vitellogenin 3, phosvitinless. (1264 aa)
	LOC103471958	Nuclear receptor subfamily 1, group D, member 2b. (583 aa)
	maml2	MamL-1 domain-containing protein. (908 aa)
	LOC103465339	Retinoic acid receptor, gamma b. (405 aa)
	LOC103465341	Nuclear receptor subfamily 1, group D, member 4b. (573 aa)
	pgr	Progesterone receptor. (642 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (740 aa)
	LOC103457290	Estrogen receptor 2a. (507 aa)
	LOC103456526	Hepatocyte nuclear factor 4, gamma. (549 aa)
	LOC103472038	Zgc:91944. (541 aa)
	LOC103469771	Zinc finger protein 703. (579 aa)
	hif1an	Hypoxia inducible factor 1 subunit alpha inhibitor. (246 aa)
	LOC103478724	Aryl hydrocarbon receptor nuclear translocator. (761 aa)
	ncoa1	Nuclear receptor coactivator 1. (1196 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	ncoa2	Nuclear receptor coactivator 2. (1521 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (587 aa)
	ENSPREP00000027951	Uncharacterized protein. (379 aa)
	crabp2	Cellular retinoic acid binding protein 2, b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (142 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1284 aa)
	LOC103457594	Uncharacterized protein. (456 aa)
	LOC103475214	Hypoxia inducible factor 1 subunit alpha, like. (653 aa)
	hnf4a	Hepatocyte nuclear factor 4, alpha. (461 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	avpr2	Arginine vasopressin receptor 2a, duplicate a. (497 aa)
	Rxra	Retinoid X receptor, alpha a. (410 aa)
	arnt2	Aryl-hydrocarbon receptor nuclear translocator 2. (679 aa)
	LOC103465576	Nuclear receptor coactivator 3. (1523 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (401 aa)
	LOC103474618	Egl-9 family hypoxia-inducible factor 2. (525 aa)
	Npas1	Neuronal PAS domain protein 1. (302 aa)
	spag7	Sperm-associated antigen 7 homolog. (236 aa)
	ENSPREP00000034277	Hepatic nuclear factor 4, beta. (375 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009170	ENSPREP00000027951	ENSPREP00000009170	ENSPREP00000027951	Endothelial PAS domain protein 1b.	Uncharacterized protein.	0.570
ENSPREP00000009170	LOC103465576	ENSPREP00000009170	ENSPREP00000033085	Endothelial PAS domain protein 1b.	Nuclear receptor coactivator 3.	0.558
ENSPREP00000009170	LOC103468460	ENSPREP00000009170	ENSPREP00000026558	Endothelial PAS domain protein 1b.	E1A binding protein p300 b.	0.753
ENSPREP00000009170	LOC103474618	ENSPREP00000009170	ENSPREP00000033711	Endothelial PAS domain protein 1b.	Egl-9 family hypoxia-inducible factor 2.	0.811
ENSPREP00000009170	LOC103478724	ENSPREP00000009170	ENSPREP00000025818	Endothelial PAS domain protein 1b.	Aryl hydrocarbon receptor nuclear translocator.	0.867
ENSPREP00000009170	LOC103482005	ENSPREP00000009170	ENSPREP00000030842	Endothelial PAS domain protein 1b.	E1A binding protein p300 a.	0.753
ENSPREP00000009170	NCOA3	ENSPREP00000009170	ENSPREP00000010962	Endothelial PAS domain protein 1b.	Nuclear receptor coactivator.	0.558
ENSPREP00000009170	arnt2	ENSPREP00000009170	ENSPREP00000033074	Endothelial PAS domain protein 1b.	Aryl-hydrocarbon receptor nuclear translocator 2.	0.867
ENSPREP00000009170	crebbp	ENSPREP00000009170	ENSPREP00000011232	Endothelial PAS domain protein 1b.	CREB binding protein b.	0.753
ENSPREP00000009170	egln1	ENSPREP00000009170	ENSPREP00000012342	Endothelial PAS domain protein 1b.	Egl-9 family hypoxia-inducible factor 1a.	0.811
ENSPREP00000009170	egln3	ENSPREP00000009170	ENSPREP00000004161	Endothelial PAS domain protein 1b.	Egl-9 family hypoxia-inducible factor 3.	0.811
ENSPREP00000009170	hif1an	ENSPREP00000009170	ENSPREP00000025789	Endothelial PAS domain protein 1b.	Hypoxia inducible factor 1 subunit alpha inhibitor.	0.860
ENSPREP00000009170	ncoa1	ENSPREP00000009170	ENSPREP00000026131	Endothelial PAS domain protein 1b.	Nuclear receptor coactivator 1.	0.558
ENSPREP00000009170	ncoa2	ENSPREP00000009170	ENSPREP00000026981	Endothelial PAS domain protein 1b.	Nuclear receptor coactivator 2.	0.558
ENSPREP00000011180	ENSPREP00000027951	ENSPREP00000011180	ENSPREP00000027951	Nuclear receptor subfamily 5, group A, member 2.	Uncharacterized protein.	0.735
ENSPREP00000011180	GATA2	ENSPREP00000011180	ENSPREP00000018023	Nuclear receptor subfamily 5, group A, member 2.	GATA binding protein 2.	0.434
ENSPREP00000011180	LOC103457290	ENSPREP00000011180	ENSPREP00000023210	Nuclear receptor subfamily 5, group A, member 2.	Estrogen receptor 2a.	0.510
ENSPREP00000011180	LOC103458082	ENSPREP00000011180	ENSPREP00000003460	Nuclear receptor subfamily 5, group A, member 2.	Estrogen receptor 2b.	0.510
ENSPREP00000011180	LOC103464934	ENSPREP00000011180	ENSPREP00000002531	Nuclear receptor subfamily 5, group A, member 2.	Vitamin D receptor b.	0.422
ENSPREP00000011180	LOC103465576	ENSPREP00000011180	ENSPREP00000033085	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor coactivator 3.	0.735