(16 nodes) Mixed, incl. NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, and Peroxisome proliferator-activated receptor network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103478548	Retinoid x receptor, beta b. (412 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (474 aa)
	RXRB	Retinoid X receptor beta. (417 aa)
	NCOA3	Nuclear receptor coactivator. (1429 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (472 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	LOC103463575	Uncharacterized protein. (438 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	LOC103471958	Nuclear receptor subfamily 1, group D, member 2b. (583 aa)
	LOC103465341	Nuclear receptor subfamily 1, group D, member 4b. (573 aa)
	ncoa1	Nuclear receptor coactivator 1. (1196 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ncoa2	Nuclear receptor coactivator 2. (1521 aa)
	Rxra	Retinoid X receptor, alpha a. (410 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (401 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103463575	LOC103467002	ENSPREP00000016159	ENSPREP00000014015	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 5.	0.806
LOC103463575	NCOA3	ENSPREP00000016159	ENSPREP00000010962	Uncharacterized protein.	Nuclear receptor coactivator.	0.703
LOC103463575	PPARA	ENSPREP00000016159	ENSPREP00000017061	Uncharacterized protein.	Peroxisome proliferator-activated receptor alpha b.	0.724
LOC103463575	PPARG	ENSPREP00000016159	ENSPREP00000009292	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.724
LOC103463575	RXRB	ENSPREP00000016159	ENSPREP00000009524	Uncharacterized protein.	Retinoid X receptor beta.	0.905
LOC103463575	Rxra	ENSPREP00000016159	ENSPREP00000032811	Uncharacterized protein.	Retinoid X receptor, alpha a.	0.907
LOC103463575	ncoa1	ENSPREP00000016159	ENSPREP00000026131	Uncharacterized protein.	Nuclear receptor coactivator 1.	0.703
LOC103463575	ncoa2	ENSPREP00000016159	ENSPREP00000026981	Uncharacterized protein.	Nuclear receptor coactivator 2.	0.703
LOC103463575	nr1h3	ENSPREP00000016159	ENSPREP00000006124	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 3.	0.923
LOC103463575	nr1h4	ENSPREP00000016159	ENSPREP00000026448	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 4.	0.806
LOC103463575	ppara	ENSPREP00000016159	ENSPREP00000013817	Uncharacterized protein.	Peroxisome proliferator-activated receptor alpha a.	0.651
LOC103463575	ppard	ENSPREP00000016159	ENSPREP00000033397	Uncharacterized protein.	Peroxisome proliferator-activated receptor delta b.	0.947
LOC103465341	LOC103467002	ENSPREP00000022194	ENSPREP00000014015	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor subfamily 1, group H, member 5.	0.731
LOC103465341	NCOA3	ENSPREP00000022194	ENSPREP00000010962	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor coactivator.	0.665
LOC103465341	PPARA	ENSPREP00000022194	ENSPREP00000017061	Nuclear receptor subfamily 1, group D, member 4b.	Peroxisome proliferator-activated receptor alpha b.	0.612
LOC103465341	PPARG	ENSPREP00000022194	ENSPREP00000009292	Nuclear receptor subfamily 1, group D, member 4b.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.591
LOC103465341	ncoa1	ENSPREP00000022194	ENSPREP00000026131	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor coactivator 1.	0.665
LOC103465341	ncoa2	ENSPREP00000022194	ENSPREP00000026981	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor coactivator 2.	0.665
LOC103465341	nr1h3	ENSPREP00000022194	ENSPREP00000006124	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor subfamily 1, group H, member 3.	0.731
LOC103465341	nr1h4	ENSPREP00000022194	ENSPREP00000026448	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor subfamily 1, group H, member 4.	0.731