(7 nodes) Mixed, incl. NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, and Regulation of urea metabolic process network (Poecilia reticulata)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	LOC103478548	Retinoid x receptor, beta b. (412 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (474 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	LOC103465341	Nuclear receptor subfamily 1, group D, member 4b. (573 aa)
	ncoa1	Nuclear receptor coactivator 1. (1196 aa)
	ncoa2	Nuclear receptor coactivator 2. (1521 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103465341	LOC103467002	ENSPREP00000022194	ENSPREP00000014015	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor subfamily 1, group H, member 5.	0.731
LOC103465341	PPARG	ENSPREP00000022194	ENSPREP00000009292	Nuclear receptor subfamily 1, group D, member 4b.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.591
LOC103465341	ncoa1	ENSPREP00000022194	ENSPREP00000026131	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor coactivator 1.	0.665
LOC103465341	ncoa2	ENSPREP00000022194	ENSPREP00000026981	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor coactivator 2.	0.665
LOC103465341	nr1h3	ENSPREP00000022194	ENSPREP00000006124	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor subfamily 1, group H, member 3.	0.731
LOC103467002	LOC103465341	ENSPREP00000014015	ENSPREP00000022194	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor subfamily 1, group D, member 4b.	0.731
LOC103467002	LOC103478548	ENSPREP00000014015	ENSPREP00000003469	Nuclear receptor subfamily 1, group H, member 5.	Retinoid x receptor, beta b.	0.806
LOC103467002	ncoa1	ENSPREP00000014015	ENSPREP00000026131	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor coactivator 1.	0.748
LOC103467002	ncoa2	ENSPREP00000014015	ENSPREP00000026981	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor coactivator 2.	0.748
LOC103478548	LOC103467002	ENSPREP00000003469	ENSPREP00000014015	Retinoid x receptor, beta b.	Nuclear receptor subfamily 1, group H, member 5.	0.806
LOC103478548	PPARG	ENSPREP00000003469	ENSPREP00000009292	Retinoid x receptor, beta b.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.724
LOC103478548	ncoa1	ENSPREP00000003469	ENSPREP00000026131	Retinoid x receptor, beta b.	Nuclear receptor coactivator 1.	0.703
LOC103478548	ncoa2	ENSPREP00000003469	ENSPREP00000026981	Retinoid x receptor, beta b.	Nuclear receptor coactivator 2.	0.703
LOC103478548	nr1h3	ENSPREP00000003469	ENSPREP00000006124	Retinoid x receptor, beta b.	Nuclear receptor subfamily 1, group H, member 3.	0.923
PPARG	LOC103465341	ENSPREP00000009292	ENSPREP00000022194	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Nuclear receptor subfamily 1, group D, member 4b.	0.591
PPARG	LOC103478548	ENSPREP00000009292	ENSPREP00000003469	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Retinoid x receptor, beta b.	0.724
PPARG	ncoa1	ENSPREP00000009292	ENSPREP00000026131	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Nuclear receptor coactivator 1.	0.669
PPARG	ncoa2	ENSPREP00000009292	ENSPREP00000026981	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Nuclear receptor coactivator 2.	0.669
PPARG	nr1h3	ENSPREP00000009292	ENSPREP00000006124	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Nuclear receptor subfamily 1, group H, member 3.	0.679
ncoa1	LOC103465341	ENSPREP00000026131	ENSPREP00000022194	Nuclear receptor coactivator 1.	Nuclear receptor subfamily 1, group D, member 4b.	0.665