(102 nodes) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rps3a	40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (266 aa)
	rps15a	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family. (152 aa)
	rpl35a	Ribosomal protein L35a. (110 aa)
	rplp0	Ribosomal protein, large, P0. (252 aa)
	rps5	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (245 aa)
	rpl28	Ribosomal protein L28. (137 aa)
	rpl37	Ribosomal protein L37; Binds to the 23S rRNA. (93 aa)
	ENSPREP00000003831	Uncharacterized protein. (102 aa)
	rps14	Ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
	cd74	CD74 molecule, major histocompatibility complex, class II invariant chain a. (297 aa)
	rps25	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (133 aa)
	rack1	Receptor for activated C kinase 1. (317 aa)
	rsad1	Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (440 aa)
	RPL27A	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. (146 aa)
	rps6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
	rps13	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (148 aa)
	rpl8	Ribosomal protein L8. (265 aa)
	LOC103477840	Ribosomal protein S19. (161 aa)
	arl6ip1	ADP-ribosylation factor-like 6 interacting protein 1. (215 aa)
	LOC103479027	SERPINE1 mRNA binding protein 1b. (404 aa)
	LOC103463733	SERPINE1 mRNA binding protein 1a. (401 aa)
	rpl3l	Ribosomal protein L3 like. (241 aa)
	LOC103480264	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
	LOC103462145	Ribosomal protein S17. (130 aa)
	rpl10	Ribosomal protein L10. (215 aa)
	rpl29	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family. (64 aa)
	ENSPREP00000010553	Ribosomal protein L18. (167 aa)
	rps9	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (136 aa)
	RPL5	Ribosomal protein L5. (298 aa)
	rpl11	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (186 aa)
	eef2	Tr-type G domain-containing protein. (858 aa)
	rpl30	Ribosomal protein L30. (116 aa)
	RPL19	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (199 aa)
	Rpl22	Uncharacterized protein. (138 aa)
	rps28	Ribosomal protein S28. (53 aa)
	rps15	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
	RPS20	Ribosomal protein S20. (119 aa)
	LOC103460099	Ribosomal protein L12; Belongs to the universal ribosomal protein uL11 family. (165 aa)
	Rpl38	Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (64 aa)
	Rpl24	Ribosomal protein L24. (156 aa)
	dock4	Dedicator of cytokinesis 4b; Belongs to the DOCK family. (1978 aa)
	rpl4	Ribosomal protein L4. (420 aa)
	Rpl31	Ribosomal protein L31. (158 aa)
	rpl22l1	Ribosomal protein L22-like 1. (129 aa)
	rps12	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Clg10h5orf45	Uncharacterized protein. (78 aa)
	LOC103456988	Eukaryotic translation initiation factor 1A X-linked b; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (152 aa)
	rpl6	Ribosomal protein L6. (259 aa)
	ifi35	Interferon-induced protein 35. (384 aa)
	rpl27	60S ribosomal protein L27; Belongs to the eukaryotic ribosomal protein eL27 family. (136 aa)
	LOC103468999	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family. (406 aa)
	rplp1	Ribosomal protein, large, P1. (132 aa)
	LOC103464700	Ribosomal protein, large P2; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
	rps7	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
	rpl39	Ribosomal protein L39. (51 aa)
	rpl17	Ribosomal protein L17; Belongs to the universal ribosomal protein uL22 family. (183 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	RPL36A	Ribosomal protein L36a; Belongs to the eukaryotic ribosomal protein eL42 family. (142 aa)
	ENSPREP00000018770	Uncharacterized protein. (73 aa)
	rps26	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (114 aa)
	RPS19	Ribosomal protein S19. (146 aa)
	rps10	Ribosomal protein S10. (204 aa)
	Rpl35	Ribosomal protein L35. (123 aa)
	LOC103461002	Ribosomal protein L22. (130 aa)
	rpl15	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
	RPL5-2	Ribosomal protein L5b. (295 aa)
	rpsa	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (307 aa)
	ENSPREP00000021034	Uncharacterized protein. (125 aa)
	ENSPREP00000021053	Uncharacterized protein. (65 aa)
	rps11	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (172 aa)
	ENSPREP00000022337	Uncharacterized protein. (57 aa)
	fau	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (133 aa)
	aknad1	Uncharacterized protein. (1239 aa)
	rps24	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (139 aa)
	rpl32	Ribosomal protein L32. (135 aa)
	LOC103478181	40S ribosomal protein S27. (124 aa)
	LOC103479455	Eukaryotic translation elongation factor 2b. (858 aa)
	rpl14	Ribosomal protein L14. (138 aa)
	rpl7	Ribosomal protein L7. (245 aa)
	rps8	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (205 aa)
	rpl18a	Ribosomal protein L18a. (182 aa)
	ENSPREP00000028465	40S ribosomal protein S27. (95 aa)
	rpl34	Ribosomal protein L34. (117 aa)
	rpl21	Ribosomal protein L21. (160 aa)
	LOC103470872	Ribosomal protein L26. (153 aa)
	wdr31	WD repeat domain 31. (313 aa)
	rpl13a	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (205 aa)
	LOC103458025	Ribosomal protein L7-like 1. (276 aa)
	rps17	Uncharacterized protein. (130 aa)
	rps21	40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (80 aa)
	RPL37A	Ribosomal protein L37a. (94 aa)
	rps18	Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family. (152 aa)
	RPL7A	Ribosomal protein L7a. (266 aa)
	hmgn5	High mobility group nucleosome binding domain 6. (81 aa)
	LOC103481251	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (197 aa)
	rps16	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (146 aa)
	LOC103474722	Uncharacterized protein. (272 aa)
	fance	FA complementation group E. (521 aa)
	LOC103462394	Ribosomal protein, large P2, like; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
	rps23	Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (145 aa)
	rpl13	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (211 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Clg10h5orf45	ENSPREP00000003831	ENSPREP00000016757	ENSPREP00000003831	Uncharacterized protein.	Uncharacterized protein.	0.983
Clg10h5orf45	ENSPREP00000010553	ENSPREP00000016757	ENSPREP00000010553	Uncharacterized protein.	Ribosomal protein L18.	0.989
Clg10h5orf45	ENSPREP00000018770	ENSPREP00000016757	ENSPREP00000018770	Uncharacterized protein.	Uncharacterized protein.	0.955
Clg10h5orf45	ENSPREP00000021034	ENSPREP00000016757	ENSPREP00000021034	Uncharacterized protein.	Uncharacterized protein.	0.980
Clg10h5orf45	ENSPREP00000021053	ENSPREP00000016757	ENSPREP00000021053	Uncharacterized protein.	Uncharacterized protein.	0.956
Clg10h5orf45	ENSPREP00000022337	ENSPREP00000016757	ENSPREP00000022337	Uncharacterized protein.	Uncharacterized protein.	0.956
Clg10h5orf45	ENSPREP00000028465	ENSPREP00000016757	ENSPREP00000028465	Uncharacterized protein.	40S ribosomal protein S27.	0.955
Clg10h5orf45	LOC103456988	ENSPREP00000016757	ENSPREP00000016848	Uncharacterized protein.	Eukaryotic translation initiation factor 1A X-linked b; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	0.984
Clg10h5orf45	LOC103458025	ENSPREP00000016757	ENSPREP00000029725	Uncharacterized protein.	Ribosomal protein L7-like 1.	0.957
Clg10h5orf45	LOC103460099	ENSPREP00000016757	ENSPREP00000013581	Uncharacterized protein.	Ribosomal protein L12; Belongs to the universal ribosomal protein uL11 family.	0.959
Clg10h5orf45	LOC103461002	ENSPREP00000016757	ENSPREP00000020152	Uncharacterized protein.	Ribosomal protein L22.	0.905
Clg10h5orf45	LOC103462145	ENSPREP00000016757	ENSPREP00000008840	Uncharacterized protein.	Ribosomal protein S17.	0.903
Clg10h5orf45	LOC103462394	ENSPREP00000016757	ENSPREP00000033448	Uncharacterized protein.	Ribosomal protein, large P2, like; Belongs to the eukaryotic ribosomal protein P1/P2 family.	0.945
Clg10h5orf45	LOC103463733	ENSPREP00000016757	ENSPREP00000008265	Uncharacterized protein.	SERPINE1 mRNA binding protein 1a.	0.715
Clg10h5orf45	LOC103464700	ENSPREP00000016757	ENSPREP00000017727	Uncharacterized protein.	Ribosomal protein, large P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	0.945
Clg10h5orf45	LOC103468999	ENSPREP00000016757	ENSPREP00000017124	Uncharacterized protein.	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.951
Clg10h5orf45	LOC103470872	ENSPREP00000016757	ENSPREP00000028923	Uncharacterized protein.	Ribosomal protein L26.	0.987
Clg10h5orf45	LOC103474722	ENSPREP00000016757	ENSPREP00000033244	Uncharacterized protein.	Uncharacterized protein.	0.979
Clg10h5orf45	LOC103477840	ENSPREP00000016757	ENSPREP00000006975	Uncharacterized protein.	Ribosomal protein S19.	0.982
Clg10h5orf45	LOC103478181	ENSPREP00000016757	ENSPREP00000025940	Uncharacterized protein.	40S ribosomal protein S27.	0.955