STRINGSTRING
LOC103479501 LOC103479501 dld dld ldhd ldhd LOC103462181 LOC103462181 LOC103465156 LOC103465156 dbt dbt LOC103471159 LOC103471159 ggnbp2 ggnbp2 LOC103466626 LOC103466626 idh3a idh3a LOC103465809 LOC103465809 LOC103466577 LOC103466577 LOC103459060 LOC103459060 suclg1 suclg1 ENSPREP00000014189 ENSPREP00000014189 SDHB SDHB LOC103480192 LOC103480192 mdh1b mdh1b ACLY ACLY pdha1 pdha1 ENSPREP00000016750 ENSPREP00000016750 ldhb ldhb fh fh LOC103481842 LOC103481842 sdha sdha pdk3 pdk3 bckdhb bckdhb bckdk bckdk ogdh ogdh me1 me1 sdhd sdhd bckdha bckdha ACO2 ACO2 dlat dlat LOC103465416 LOC103465416 ENSPREP00000026406 ENSPREP00000026406 me2 me2 suclg2 suclg2 txnrd2 txnrd2 pdhx pdhx LOC103466147 LOC103466147 DLST DLST idh3b idh3b LOC103475425 LOC103475425 LOC103475424 LOC103475424 pc pc ENSPREP00000029837 ENSPREP00000029837 idh1 idh1 LOC103481996 LOC103481996 aco1 aco1 idh3g idh3g LOC103481260 LOC103481260 cs cs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103479501Succinate dehydrogenase complex, subunit C, integral membrane protein. (153 aa)
dldDihydrolipoyl dehydrogenase. (508 aa)
ldhdLactate dehydrogenase D. (496 aa)
LOC103462181Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (455 aa)
LOC103465156Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (290 aa)
dbtDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (492 aa)
LOC103471159Malate synthase-like. (467 aa)
ggnbp2Gametogenetin binding protein 2. (671 aa)
LOC103466626Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
idh3aIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (371 aa)
LOC103465809L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (355 aa)
LOC103466577Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (362 aa)
LOC103459060Dihydrolipoamide S-succinyltransferase. (433 aa)
suclg1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (337 aa)
ENSPREP00000014189Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (202 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (339 aa)
LOC103480192Malic enzyme. (454 aa)
mdh1bMalate dehydrogenase 1B, NAD (soluble). (516 aa)
ACLYATP citrate lyase. (1056 aa)
pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (400 aa)
ENSPREP00000016750Succinate-CoA ligase, ADP-forming, beta subunit. (378 aa)
ldhbL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
fhFumarate hydratase. (499 aa)
LOC103481842Protein-serine/threonine kinase. (385 aa)
sdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (663 aa)
pdk3Protein-serine/threonine kinase. (404 aa)
bckdhbBranched chain keto acid dehydrogenase E1 subunit beta. (387 aa)
bckdkProtein-serine/threonine kinase. (429 aa)
ogdhOxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide). (1019 aa)
me1Malic enzyme. (588 aa)
sdhdSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (166 aa)
bckdha2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (447 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (772 aa)
dlatAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (643 aa)
LOC103465416Thioredoxin reductase 3. (600 aa)
ENSPREP00000026406Oxoglutarate dehydrogenase. (353 aa)
me2Malic enzyme. (582 aa)
suclg2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (428 aa)
txnrd2Thioredoxin reductase 2, tandem duplicate 1. (512 aa)
pdhxDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
LOC103466147L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
DLSTDihydrolipoamide S-succinyltransferase. (436 aa)
idh3bIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
LOC103475425Uncharacterized protein. (609 aa)
LOC103475424Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
pcPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1180 aa)
ENSPREP00000029837Uncharacterized protein. (88 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
LOC103481996Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
aco1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (894 aa)
idh3gIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (389 aa)
LOC103481260ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1121 aa)
csCitrate synthase; Belongs to the citrate synthase family. (469 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.