(12 nodes) Dihydrolipoyl dehydrogenase complex, and Pyruvate dehydrogenase complex network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dld	Dihydrolipoyl dehydrogenase. (508 aa)
	dbt	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (492 aa)
	LOC103459060	Dihydrolipoamide S-succinyltransferase. (433 aa)
	ENSPREP00000014189	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (202 aa)
	bckdhb	Branched chain keto acid dehydrogenase E1 subunit beta. (387 aa)
	bckdha	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (447 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (643 aa)
	LOC103465416	Thioredoxin reductase 3. (600 aa)
	ENSPREP00000026406	Oxoglutarate dehydrogenase. (353 aa)
	txnrd2	Thioredoxin reductase 2, tandem duplicate 1. (512 aa)
	pdhx	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
	LOC103475424	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000014189	ENSPREP00000026406	ENSPREP00000014189	ENSPREP00000026406	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Oxoglutarate dehydrogenase.	0.863
ENSPREP00000014189	LOC103459060	ENSPREP00000014189	ENSPREP00000013689	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide S-succinyltransferase.	0.964
ENSPREP00000014189	LOC103465416	ENSPREP00000014189	ENSPREP00000026356	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Thioredoxin reductase 3.	0.915
ENSPREP00000014189	LOC103475424	ENSPREP00000014189	ENSPREP00000029554	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ENSPREP00000014189	bckdha	ENSPREP00000014189	ENSPREP00000024063	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
ENSPREP00000014189	bckdhb	ENSPREP00000014189	ENSPREP00000022601	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.691
ENSPREP00000014189	dbt	ENSPREP00000014189	ENSPREP00000008184	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.964
ENSPREP00000014189	dlat	ENSPREP00000014189	ENSPREP00000026249	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ENSPREP00000014189	dld	ENSPREP00000014189	ENSPREP00000003162	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoyl dehydrogenase.	0.999
ENSPREP00000014189	pdhx	ENSPREP00000014189	ENSPREP00000028190	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.998
ENSPREP00000014189	txnrd2	ENSPREP00000014189	ENSPREP00000027510	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Thioredoxin reductase 2, tandem duplicate 1.	0.915
ENSPREP00000026406	ENSPREP00000014189	ENSPREP00000026406	ENSPREP00000014189	Oxoglutarate dehydrogenase.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.863
ENSPREP00000026406	LOC103459060	ENSPREP00000026406	ENSPREP00000013689	Oxoglutarate dehydrogenase.	Dihydrolipoamide S-succinyltransferase.	0.984
ENSPREP00000026406	LOC103465416	ENSPREP00000026406	ENSPREP00000026356	Oxoglutarate dehydrogenase.	Thioredoxin reductase 3.	0.862
ENSPREP00000026406	LOC103475424	ENSPREP00000026406	ENSPREP00000029554	Oxoglutarate dehydrogenase.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.778
ENSPREP00000026406	bckdha	ENSPREP00000026406	ENSPREP00000024063	Oxoglutarate dehydrogenase.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.807
ENSPREP00000026406	bckdhb	ENSPREP00000026406	ENSPREP00000022601	Oxoglutarate dehydrogenase.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.798
ENSPREP00000026406	dbt	ENSPREP00000026406	ENSPREP00000008184	Oxoglutarate dehydrogenase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.944
ENSPREP00000026406	dlat	ENSPREP00000026406	ENSPREP00000026249	Oxoglutarate dehydrogenase.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.947
ENSPREP00000026406	dld	ENSPREP00000026406	ENSPREP00000003162	Oxoglutarate dehydrogenase.	Dihydrolipoyl dehydrogenase.	0.989