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tat tat SHMT2 SHMT2 grhpr grhpr LOC103460525 LOC103460525 LOC103458637 LOC103458637 mtr mtr LOC103461226 LOC103461226 phgdh phgdh amt amt mthfd1l mthfd1l mat2b mat2b AHCYL1 AHCYL1 pdpr pdpr ENSPREP00000006862 ENSPREP00000006862 glyctk glyctk LOC103460681 LOC103460681 cth cth LOC103461416 LOC103461416 LOC103466594 LOC103466594 gart gart alas1 alas1 fpgs fpgs iba57 iba57 tyms tyms SDS SDS gldc gldc sardh sardh shmt2 shmt2 LOC103472444 LOC103472444 psat1 psat1 mthfr mthfr LOC103469985 LOC103469985 LOC103481118 LOC103481118 LOC103473691 LOC103473691 LOC103477344 LOC103477344 hao1 hao1 LOC103468992 LOC103468992 ENSPREP00000017739 ENSPREP00000017739 mthfs mthfs dhfr dhfr LOC103470081 LOC103470081 LOC103470080 LOC103470080 LOC103474492 LOC103474492 LOC103459585 LOC103459585 ahcyl1 ahcyl1 LOC103463960 LOC103463960 pipox pipox ENSPREP00000022276 ENSPREP00000022276 pgp pgp ENSPREP00000023632 ENSPREP00000023632 LOC103459710 LOC103459710 LOC103463929 LOC103463929 LOC103466078 LOC103466078 LOC103473263 LOC103473263 shmt1 shmt1 LOC103457821 LOC103457821 LOC103476873 LOC103476873 LOC103457629 LOC103457629 dmgdh dmgdh LOC103473309 LOC103473309 hao2 hao2 ppat ppat LOC103463823 LOC103463823 impact impact LOC103465496 LOC103465496 LOC103466197 LOC103466197 hoga1 hoga1 mthfd2 mthfd2 LOC103470277 LOC103470277 mthfd1 mthfd1 psph psph mtfmt mtfmt LOC103459803 LOC103459803 LOC103468004 LOC103468004 gcsh gcsh
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tatTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (449 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (530 aa)
grhprGlyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
LOC103460525Serine palmitoyltransferase, long chain base subunit 2a. (565 aa)
LOC103458637L-threonine dehydrogenase 2. (308 aa)
mtrMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1275 aa)
LOC103461226Trimethyllysine hydroxylase, epsilon. (407 aa)
phgdhD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
amtAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (415 aa)
mthfd1lMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (695 aa)
mat2bMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (325 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (550 aa)
pdprPyruvate dehydrogenase phosphatase regulatory subunit. (892 aa)
ENSPREP00000006862Uncharacterized protein. (144 aa)
glyctkGlycerate kinase. (524 aa)
LOC103460681Serine dehydratase-like. (313 aa)
cthCystathionase (cystathionine gamma-lyase), like. (441 aa)
LOC103461416Serine--pyruvate aminotransferase. (360 aa)
LOC103466594Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (359 aa)
gartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
alas15-aminolevulinate synthase. (623 aa)
fpgsFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (576 aa)
iba57Iron-sulfur cluster assembly factor IBA57. (366 aa)
tymsThymidylate synthetase. (322 aa)
SDSSerine dehydratase. (346 aa)
gldcGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1043 aa)
sardhSarcosine dehydrogenase. (916 aa)
shmt2Serine hydroxymethyltransferase 2 (mitochondrial). (515 aa)
LOC103472444Zgc:136493; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
psat1Phosphoserine aminotransferase. (369 aa)
mthfrMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (645 aa)
LOC103469985Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (398 aa)
LOC103481118Formimidoyltransferase cyclodeaminase. (539 aa)
LOC103473691S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
LOC103477344PALP domain-containing protein. (529 aa)
hao1Hydroxyacid oxidase (glycolate oxidase) 1. (373 aa)
LOC103468992Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
ENSPREP00000017739Uncharacterized protein. (65 aa)
mthfs5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (199 aa)
dhfrDihydrofolate reductase. (187 aa)
LOC103470081Hcy-binding domain-containing protein. (435 aa)
LOC103470080Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (397 aa)
LOC103474492Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (582 aa)
LOC103459585Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa)
ahcyl1Adenosylhomocysteinase-like 1; Belongs to the adenosylhomocysteinase family. (555 aa)
LOC103463960Serine--pyruvate aminotransferase. (434 aa)
pipoxPipecolic acid oxidase. (388 aa)
ENSPREP00000022276Uncharacterized protein. (107 aa)
pgpPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (312 aa)
ENSPREP000000236322-Hacid_dh_C domain-containing protein. (103 aa)
LOC10345971010-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
LOC103463929Zgc:172121. (369 aa)
LOC103466078AdoHcyase_NAD domain-containing protein; Belongs to the adenosylhomocysteinase family. (578 aa)
LOC103473263S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (390 aa)
shmt1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (442 aa)
LOC103457821Serine palmitoyltransferase, long chain base subunit 2b. (564 aa)
LOC103476873S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
LOC103457629L-threonine dehydrogenase. (374 aa)
dmgdhDimethylglycine dehydrogenase. (870 aa)
LOC103473309Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (397 aa)
hao2Hydroxyacid oxidase 2 (long chain). (392 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa)
LOC103463823AIRC domain-containing protein. (1012 aa)
impactImpact RWD domain protein. (320 aa)
LOC10346549610-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
LOC103466197Zgc:153031. (198 aa)
hoga14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (323 aa)
mthfd2Uncharacterized protein. (338 aa)
LOC103470277S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (362 aa)
mthfd1Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
psphPhosphoserine phosphatase. (244 aa)
mtfmtMitochondrial methionyl-tRNA formyltransferase. (374 aa)
LOC103459803Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (587 aa)
LOC1034680045-aminolevulinate synthase. (615 aa)
gcshGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (174 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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