(28 nodes) One carbon pool by folate, and Glycine cleavage complex network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (530 aa)
	phgdh	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (415 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (695 aa)
	pdpr	Pyruvate dehydrogenase phosphatase regulatory subunit. (892 aa)
	ENSPREP00000006862	Uncharacterized protein. (144 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
	fpgs	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (576 aa)
	iba57	Iron-sulfur cluster assembly factor IBA57. (366 aa)
	tyms	Thymidylate synthetase. (322 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1043 aa)
	shmt2	Serine hydroxymethyltransferase 2 (mitochondrial). (515 aa)
	psat1	Phosphoserine aminotransferase. (369 aa)
	LOC103469985	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (398 aa)
	LOC103481118	Formimidoyltransferase cyclodeaminase. (539 aa)
	ENSPREP00000017739	Uncharacterized protein. (65 aa)
	mthfs	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (199 aa)
	dhfr	Dihydrofolate reductase. (187 aa)
	LOC103459710	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (442 aa)
	ppat	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa)
	LOC103463823	AIRC domain-containing protein. (1012 aa)
	LOC103465496	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	LOC103466197	Zgc:153031. (198 aa)
	mthfd2	Uncharacterized protein. (338 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	mtfmt	Mitochondrial methionyl-tRNA formyltransferase. (374 aa)
	gcsh	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (174 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006862	LOC103463823	ENSPREP00000006862	ENSPREP00000029834	Uncharacterized protein.	AIRC domain-containing protein.	0.504
ENSPREP00000006862	LOC103466197	ENSPREP00000006862	ENSPREP00000031007	Uncharacterized protein.	Zgc:153031.	0.774
ENSPREP00000006862	LOC103469985	ENSPREP00000006862	ENSPREP00000013812	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.845
ENSPREP00000006862	LOC103481118	ENSPREP00000006862	ENSPREP00000015435	Uncharacterized protein.	Formimidoyltransferase cyclodeaminase.	0.573
ENSPREP00000006862	SHMT2	ENSPREP00000006862	ENSPREP00000002198	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.833
ENSPREP00000006862	amt	ENSPREP00000006862	ENSPREP00000005551	Uncharacterized protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.978
ENSPREP00000006862	dhfr	ENSPREP00000006862	ENSPREP00000017926	Uncharacterized protein.	Dihydrofolate reductase.	0.774
ENSPREP00000006862	fpgs	ENSPREP00000006862	ENSPREP00000011117	Uncharacterized protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.450
ENSPREP00000006862	gart	ENSPREP00000006862	ENSPREP00000009460	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.867
ENSPREP00000006862	gldc	ENSPREP00000006862	ENSPREP00000012159	Uncharacterized protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.993
ENSPREP00000006862	iba57	ENSPREP00000006862	ENSPREP00000011181	Uncharacterized protein.	Iron-sulfur cluster assembly factor IBA57.	0.895
ENSPREP00000006862	mtfmt	ENSPREP00000006862	ENSPREP00000032756	Uncharacterized protein.	Mitochondrial methionyl-tRNA formyltransferase.	0.605
ENSPREP00000006862	mthfd1	ENSPREP00000006862	ENSPREP00000032284	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.501
ENSPREP00000006862	mthfd1l	ENSPREP00000006862	ENSPREP00000005791	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.501
ENSPREP00000006862	mthfd2	ENSPREP00000006862	ENSPREP00000031488	Uncharacterized protein.	Uncharacterized protein.	0.845
ENSPREP00000006862	mthfs	ENSPREP00000006862	ENSPREP00000017828	Uncharacterized protein.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.447
ENSPREP00000006862	pdpr	ENSPREP00000006862	ENSPREP00000006852	Uncharacterized protein.	Pyruvate dehydrogenase phosphatase regulatory subunit.	0.916
ENSPREP00000006862	phgdh	ENSPREP00000006862	ENSPREP00000005247	Uncharacterized protein.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.606
ENSPREP00000006862	ppat	ENSPREP00000006862	ENSPREP00000029819	Uncharacterized protein.	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.465
ENSPREP00000006862	psat1	ENSPREP00000006862	ENSPREP00000013365	Uncharacterized protein.	Phosphoserine aminotransferase.	0.588