(81 nodes) Valine, leucine and isoleucine degradation, and Fatty acid beta-oxidation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103463151	Uncharacterized protein. (107 aa)
	hibch	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (382 aa)
	cryl1	Crystallin, lambda 1. (295 aa)
	LOC103470362	Uncharacterized protein. (625 aa)
	adhfe1	Alcohol dehydrogenase iron containing 1. (526 aa)
	LOC103478572	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa)
	hmgcl	3-hydroxy-3-methylglutaryl-CoA lyase. (298 aa)
	LOC103468105	Acyl-CoA synthetase short chain family member 2. (376 aa)
	echdc2	Enoyl CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (332 aa)
	ENSPREP00000003552	ADH_zinc_N domain-containing protein. (214 aa)
	hadh	Hydroxyacyl-CoA dehydrogenase. (318 aa)
	LOC103472241	Zgc:85777. (434 aa)
	acox3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (692 aa)
	amacr	Alpha-methylacyl-CoA racemase. (382 aa)
	bbox1	Butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1. (447 aa)
	acaa1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	auh	AU RNA binding protein/enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (319 aa)
	LOC103479006	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family. (518 aa)
	smox	Spermine oxidase. (571 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (363 aa)
	LOC103468150	Amine oxidase. (799 aa)
	ENSPREP00000010030	Electron transfer flavoprotein subunit beta. (243 aa)
	acadsb	Acyl-CoA dehydrogenase short/branched chain. (432 aa)
	aldh3b1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (469 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (657 aa)
	ENSPREP00000011559	Uncharacterized protein. (69 aa)
	etfdh	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (622 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (347 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	mccc2	Methylcrotonoyl-CoA carboxylase 2 (beta). (564 aa)
	acad11	Acyl-CoA dehydrogenase family, member 11. (758 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (282 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (718 aa)
	Sugct	Succinyl-CoA:glutarate-CoA transferase. (255 aa)
	eci2	Enoyl-CoA delta isomerase 2. (397 aa)
	acss2	Acetyl-coenzyme A synthetase. (669 aa)
	aldh6a1	Aldehyde dehydrogenase 6 family member A1. (526 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	LOC103470603	4-hydroxyphenylpyruvate dioxygenase b. (559 aa)
	LOC103458445	Uncharacterized protein. (108 aa)
	LOC103465889	Glutamate decarboxylase like 1. (510 aa)
	acad8	Acyl-CoA dehydrogenase family, member 8. (419 aa)
	acaa2	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	pccb	Propionyl-CoA carboxylase subunit beta. (561 aa)
	aoc1	Amine oxidase. (742 aa)
	acadvl	Acyl-CoA dehydrogenase very long chain. (658 aa)
	aldh16a1	Aldehyde dehydrogenase 16 family, member A1. (797 aa)
	eci1	Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (302 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase 1. (163 aa)
	cpt2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (667 aa)
	GCDH	Glutaryl-CoA dehydrogenase b. (447 aa)
	ENSPREP00000020110	Si:dkey-61n16.5. (121 aa)
	aldh9a1	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family. (505 aa)
	acads	Acyl-CoA dehydrogenase short chain. (405 aa)
	hadha	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (757 aa)
	aldh5a1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa)
	LOC103474340	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
	LOC103457893	Aldedh domain-containing protein. (493 aa)
	hadhb	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (327 aa)
	oxct1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (548 aa)
	ivd	Isovaleryl-CoA dehydrogenase. (417 aa)
	LOC103462972	Uncharacterized protein. (130 aa)
	hsdl2	Hydroxysteroid dehydrogenase like 2. (490 aa)
	LOC103482491	Zgc:101569; Belongs to the enoyl-CoA hydratase/isomerase family. (315 aa)
	agxt2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
	aldh2	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family. (522 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (422 aa)
	dip2c	Disco interacting protein 2 homolog C. (1520 aa)
	acox1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	LOC103457587	Acetyl-coenzyme A synthetase. (680 aa)
	LOC103466773	Uncharacterized protein. (102 aa)
	bdh1	3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (361 aa)
	echs1	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
	LOC103472186	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (326 aa)
	HTD2	Hydroxyacyl-thioester dehydratase type 2. (158 aa)
	hmgcll1	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (336 aa)
	acss3	Acyl-CoA synthetase short chain family member 3. (876 aa)
	LOC103470338	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (714 aa)
	LOC103463128	Si:ch211-198n5.11. (534 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ECHDC1	ENSPREP00000010030	ENSPREP00000018980	ENSPREP00000010030	Ethylmalonyl-CoA decarboxylase 1.	Electron transfer flavoprotein subunit beta.	0.693
ECHDC1	ENSPREP00000011559	ENSPREP00000018980	ENSPREP00000011559	Ethylmalonyl-CoA decarboxylase 1.	Uncharacterized protein.	0.444
ECHDC1	ENSPREP00000020110	ENSPREP00000018980	ENSPREP00000020110	Ethylmalonyl-CoA decarboxylase 1.	Si:dkey-61n16.5.	0.676
ECHDC1	GCDH	ENSPREP00000018980	ENSPREP00000020070	Ethylmalonyl-CoA decarboxylase 1.	Glutaryl-CoA dehydrogenase b.	0.676
ECHDC1	HTD2	ENSPREP00000018980	ENSPREP00000032281	Ethylmalonyl-CoA decarboxylase 1.	Hydroxyacyl-thioester dehydratase type 2.	0.469
ECHDC1	LOC103457587	ENSPREP00000018980	ENSPREP00000029311	Ethylmalonyl-CoA decarboxylase 1.	Acetyl-coenzyme A synthetase.	0.518
ECHDC1	LOC103457893	ENSPREP00000018980	ENSPREP00000023286	Ethylmalonyl-CoA decarboxylase 1.	Aldedh domain-containing protein.	0.400
ECHDC1	LOC103458445	ENSPREP00000018980	ENSPREP00000015848	Ethylmalonyl-CoA decarboxylase 1.	Uncharacterized protein.	0.736
ECHDC1	LOC103462972	ENSPREP00000018980	ENSPREP00000025617	Ethylmalonyl-CoA decarboxylase 1.	Uncharacterized protein.	0.736
ECHDC1	LOC103463128	ENSPREP00000018980	ENSPREP00000033644	Ethylmalonyl-CoA decarboxylase 1.	Si:ch211-198n5.11.	0.542
ECHDC1	LOC103463151	ENSPREP00000018980	ENSPREP00000001140	Ethylmalonyl-CoA decarboxylase 1.	Uncharacterized protein.	0.736
ECHDC1	LOC103466773	ENSPREP00000018980	ENSPREP00000029810	Ethylmalonyl-CoA decarboxylase 1.	Uncharacterized protein.	0.736
ECHDC1	LOC103468105	ENSPREP00000018980	ENSPREP00000002688	Ethylmalonyl-CoA decarboxylase 1.	Acyl-CoA synthetase short chain family member 2.	0.518
ECHDC1	LOC103470362	ENSPREP00000018980	ENSPREP00000001641	Ethylmalonyl-CoA decarboxylase 1.	Uncharacterized protein.	0.635
ECHDC1	LOC103470603	ENSPREP00000018980	ENSPREP00000015515	Ethylmalonyl-CoA decarboxylase 1.	4-hydroxyphenylpyruvate dioxygenase b.	0.466
ECHDC1	LOC103472186	ENSPREP00000018980	ENSPREP00000031973	Ethylmalonyl-CoA decarboxylase 1.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.417
ECHDC1	LOC103472241	ENSPREP00000018980	ENSPREP00000003711	Ethylmalonyl-CoA decarboxylase 1.	Zgc:85777.	0.751
ECHDC1	LOC103478572	ENSPREP00000018980	ENSPREP00000001952	Ethylmalonyl-CoA decarboxylase 1.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.417
ECHDC1	Sugct	ENSPREP00000018980	ENSPREP00000014332	Ethylmalonyl-CoA decarboxylase 1.	Succinyl-CoA:glutarate-CoA transferase.	0.497
ECHDC1	aacs	ENSPREP00000018980	ENSPREP00000012586	Ethylmalonyl-CoA decarboxylase 1.	Acetoacetyl-CoA synthetase.	0.518