(5 nodes) Coenzyme A binding, and Sterol biosynthesis network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein homology

Your Input:
	LOC103473119	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (577 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	PMVK	Phosphomevalonate kinase. (257 aa)
	LOC103473284	3-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (389 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103473119	LOC103473284	ENSPREP00000017837	ENSPREP00000027438	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
LOC103473119	PMVK	ENSPREP00000017837	ENSPREP00000023595	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Phosphomevalonate kinase.	0.654
LOC103473119	hmgcr	ENSPREP00000017837	ENSPREP00000018171	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
LOC103473119	mvk	ENSPREP00000017837	ENSPREP00000033104	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.837
LOC103473284	LOC103473119	ENSPREP00000027438	ENSPREP00000017837	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
LOC103473284	PMVK	ENSPREP00000027438	ENSPREP00000023595	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase.	0.479
LOC103473284	hmgcr	ENSPREP00000027438	ENSPREP00000018171	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC103473284	mvk	ENSPREP00000027438	ENSPREP00000033104	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.993
PMVK	LOC103473119	ENSPREP00000023595	ENSPREP00000017837	Phosphomevalonate kinase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.654
PMVK	LOC103473284	ENSPREP00000023595	ENSPREP00000027438	Phosphomevalonate kinase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.479
PMVK	hmgcr	ENSPREP00000023595	ENSPREP00000018171	Phosphomevalonate kinase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.555
PMVK	mvk	ENSPREP00000023595	ENSPREP00000033104	Phosphomevalonate kinase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.978
hmgcr	LOC103473119	ENSPREP00000018171	ENSPREP00000017837	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
hmgcr	LOC103473284	ENSPREP00000018171	ENSPREP00000027438	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
hmgcr	PMVK	ENSPREP00000018171	ENSPREP00000023595	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase.	0.555
hmgcr	mvk	ENSPREP00000018171	ENSPREP00000033104	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.994
mvk	LOC103473119	ENSPREP00000033104	ENSPREP00000017837	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.837
mvk	LOC103473284	ENSPREP00000033104	ENSPREP00000027438	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.993
mvk	PMVK	ENSPREP00000033104	ENSPREP00000023595	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Phosphomevalonate kinase.	0.978
mvk	hmgcr	ENSPREP00000033104	ENSPREP00000018171	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.994