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| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1463 aa) |
| | ENSPREP00000000518 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (415 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (841 aa) |
| | rad51 | RAD51 recombinase. (219 aa) |
| | atad5 | ATPase family AAA domain containing 5a. (1822 aa) |
| | ENSPREP00000001831 | Uncharacterized protein. (301 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (629 aa) |
| | ENSPREP00000001895 | Piezo_RRas_bdg domain-containing protein. (569 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (726 aa) |
| | fancb | FA complementation group B. (869 aa) |
| | fancg | FA complementation group G. (573 aa) |
| | mcmbp | Minichromosome maintenance complex binding protein. (630 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | cdca7l | Cell division cycle associated 7b. (397 aa) |
| | polk | Polymerase (DNA directed) kappa. (880 aa) |
| | poln | Polymerase (DNA directed) nu. (1294 aa) |
| | LOC103476593 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (792 aa) |
| | LOC103480107 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (822 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (357 aa) |
| | ENSPREP00000006911 | Uncharacterized protein. (216 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | faap24 | FA core complex associated protein 24. (217 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa) |
| | cdca7 | Cell division cycle associated 7a. (403 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (880 aa) |
| | rpa2 | Replication protein A2. (256 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1453 aa) |
| | ddx11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (815 aa) |
| | rbpms2 | RNA binding protein, mRNA processing factor 2b. (220 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1355 aa) |
| | hes1 | Hairy-related 6. (277 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa) |
| | rfc1 | Replication factor C subunit 1. (1090 aa) |
| | LOC103479103 | Zgc:110269. (322 aa) |
| | poli | Polymerase (DNA directed) iota. (672 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | blm | BLM RecQ like helicase. (1399 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (620 aa) |
| | gmnn | Geminin DNA replication inhibitor. (209 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae). (610 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (254 aa) |
| | rev1 | REV1 DNA directed polymerase. (1360 aa) |
| | LOC103472430 | NTF2 domain-containing protein. (130 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (644 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa) |
| | dna2 | Uncharacterized protein. (1328 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (385 aa) |
| | fancd2 | FA complementation group D2. (1432 aa) |
| | mlh3 | MutL homolog 3 (E. coli). (1117 aa) |
| | fancl | FA complementation group L. (371 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa) |
| | CLSPN | Claspin. (1239 aa) |
| | LOC103474198 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (245 aa) |
| | ercc1 | Excision repair cross-complementation group 1. (358 aa) |
| | mad2l2 | Mitotic arrest deficient 2 like 2. (192 aa) |
| | rbbp8 | Uncharacterized protein. (647 aa) |
| | xrcc2 | X-ray repair cross complementing 2. (292 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (705 aa) |
| | msh4 | MutS homolog 4. (848 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (573 aa) |
| | Neurog1 | Neurogenin 1. (202 aa) |
| | bard1 | BRCA1 associated RING domain 1. (722 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | recql4 | RecQ helicase-like 4. (1237 aa) |
| | brca2 | BRCA2 DNA repair associated. (3038 aa) |
| | msh3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1117 aa) |
| | helq | Helicase, POLQ like. (1019 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | LOC103463524 | SCY domain-containing protein. (192 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | rad51c | RAD51 paralog C. (377 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | mdc1 | Uncharacterized protein. (2088 aa) |
| | pold1 | DNA polymerase. (1102 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (104 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (541 aa) |
| | rad51d | RAD51 paralog D. (350 aa) |
| | fancf | FA complementation group F. (343 aa) |
| | timeless | Timeless circadian clock. (1173 aa) |
| | pola1 | DNA polymerase. (1478 aa) |
| | atrip | Uncharacterized protein. (763 aa) |
| | fan1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (941 aa) |
| | Mcm5 | Uncharacterized protein. (58 aa) |
| | polh | Polymerase (DNA directed), eta. (716 aa) |
| | brip1 | BRCA1 interacting protein C-terminal helicase 1. (1386 aa) |
| | hes4 | Hairy-related 9. (282 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (464 aa) |
| | recql5 | RecQ helicase-like 5. (1020 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (616 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (873 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (442 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (669 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (343 aa) |
| | dbf4 | DBF4 zinc finger. (593 aa) |
| | chek2 | Checkpoint kinase 2. (510 aa) |
| | nbn | Nibrin. (843 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3091 aa) |
| | ercc4 | Excision repair cross-complementation group 4. (893 aa) |
| | fancc | FA complementation group C. (596 aa) |
| | dmc1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa) |
| | top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa) |
| | LOC103482091 | Essential meiotic structure-specific endonuclease 1. (232 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1579 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2643 aa) |
| | ENSPREP00000026167 | F-box DNA helicase 1. (875 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (396 aa) |
| | LOC103482478 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa) |
| | LOC103459742 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa) |
| | MPHOSPH9 | Uncharacterized protein. (1315 aa) |
| | msh5 | MutS homolog 5. (816 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1019 aa) |
| | exo1 | Exonuclease 1. (757 aa) |
| | rad54b | RAD54 homolog B. (937 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (1104 aa) |
| | fanci | FA complementation group I. (1325 aa) |
| | EME2 | ERCC4 domain-containing protein. (370 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (134 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (814 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa) |
| | LOC103467425 | Zgc:194242. (404 aa) |
| | fancm | Uncharacterized protein. (1901 aa) |
| | FAAP100 | FA core complex associated protein 100. (818 aa) |
| | rad54l | RAD54 like. (739 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (680 aa) |
| | lig1 | DNA ligase. (1002 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (2776 aa) |
| | orc3 | Origin recognition complex, subunit 3. (723 aa) |
| | fanca | Fanconi_A_N domain-containing protein. (965 aa) |
| | mcm9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (923 aa) |
| | tdrd3 | Tudor domain containing 3. (786 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | orc2 | Origin recognition complex, subunit 2. (578 aa) |
| | nutf2 | Nuclear transport factor 2. (127 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (586 aa) |
| | mcph1 | Microcephalin 1. (808 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | orc5 | Origin recognition complex, subunit 5. (411 aa) |
| | LOC103481268 | DBF4-type domain-containing protein. (697 aa) |
| | rhno1 | Si:ch73-352p4.5. (221 aa) |
| | brca1 | Uncharacterized protein. (1344 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa) |
| | ENSPREP00000033302 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa) |
| | dclre1a | DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (895 aa) |
| | rpl10a | Ribosomal protein; Belongs to the universal ribosomal protein uL1 family. (213 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (887 aa) |
| | dclre1b | DNA cross-link repair 1B. (566 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1380 aa) |
