STRINGSTRING
ENSPREP00000000518 ENSPREP00000000518 rad51 rad51 atad5 atad5 cdca7l cdca7l polk polk rfc2 rfc2 rfc5 rfc5 pole2 pole2 cdca7 cdca7 slf1 slf1 topbp1 topbp1 ddx11 ddx11 rad50 rad50 prim1 prim1 rfc1 rfc1 LOC103479103 LOC103479103 poli poli blm blm rmi2 rmi2 rev1 rev1 exd2 exd2 pole3 pole3 dna2 dna2 dscc1 dscc1 pold2 pold2 RPA1 RPA1 LOC103474198 LOC103474198 hus1 hus1 mad2l2 mad2l2 rbbp8 rbbp8 xrcc2 xrcc2 rfc3 rfc3 rad17 rad17 atr atr bard1 bard1 xrcc3 xrcc3 pcna pcna recql4 recql4 brca2 brca2 rfc4 rfc4 LOC103463524 LOC103463524 pole4 pole4 rpa3 rpa3 rad51c rad51c mdc1 mdc1 pold1 pold1 rad51d rad51d pola1 pola1 polh polh brip1 brip1 recql5 recql5 rad9b rad9b pola2 pola2 rad52 rad52 chek2 chek2 nbn nbn atm atm dmc1 dmc1 top3b top3b rad1 rad1 tp53bp1 tp53bp1 rad9a rad9a ENSPREP00000026167 ENSPREP00000026167 fen1 fen1 LOC103482478 LOC103482478 LOC103459742 LOC103459742 top3a top3a exo1 exo1 chtf8 chtf8 rmi1 rmi1 pold3 pold3 lig1 lig1 rev3l rev3l tdrd3 tdrd3 mcph1 mcph1 rhno1 rhno1 brca1 brca1 prim2 prim2 POLE POLE ENSPREP00000033302 ENSPREP00000033302 mre11 mre11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPREP00000000518CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (415 aa)
rad51RAD51 recombinase. (219 aa)
atad5ATPase family AAA domain containing 5a. (1822 aa)
cdca7lCell division cycle associated 7b. (397 aa)
polkPolymerase (DNA directed) kappa. (880 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
cdca7Cell division cycle associated 7a. (403 aa)
slf1SMC5-SMC6 complex localization factor 1. (880 aa)
topbp1DNA topoisomerase II binding protein 1. (1453 aa)
ddx11DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (815 aa)
rad50RAD50 homolog, double strand break repair protein. (1355 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
rfc1Replication factor C subunit 1. (1090 aa)
LOC103479103Zgc:110269. (322 aa)
poliPolymerase (DNA directed) iota. (672 aa)
blmBLM RecQ like helicase. (1399 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
rev1REV1 DNA directed polymerase. (1360 aa)
exd2Exonuclease 3'-5' domain containing 2. (644 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa)
dna2Uncharacterized protein. (1328 aa)
dscc1DNA replication and sister chromatid cohesion 1. (385 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (245 aa)
mad2l2Mitotic arrest deficient 2 like 2. (192 aa)
rbbp8Uncharacterized protein. (647 aa)
xrcc2X-ray repair cross complementing 2. (292 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rad17RAD17 checkpoint clamp loader component. (705 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
bard1BRCA1 associated RING domain 1. (722 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
recql4RecQ helicase-like 4. (1237 aa)
brca2BRCA2 DNA repair associated. (3038 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC103463524SCY domain-containing protein. (192 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
rpa3Replication protein A3. (122 aa)
rad51cRAD51 paralog C. (377 aa)
mdc1Uncharacterized protein. (2088 aa)
pold1DNA polymerase. (1102 aa)
rad51dRAD51 paralog D. (350 aa)
pola1DNA polymerase. (1478 aa)
polhPolymerase (DNA directed), eta. (716 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1386 aa)
recql5RecQ helicase-like 5. (1020 aa)
rad9bRAD9 checkpoint clamp component B. (442 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (669 aa)
rad52RAD52 homolog, DNA repair protein. (343 aa)
chek2Checkpoint kinase 2. (510 aa)
nbnNibrin. (843 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1579 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
ENSPREP00000026167F-box DNA helicase 1. (875 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (396 aa)
LOC103482478Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa)
LOC103459742Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1019 aa)
exo1Exonuclease 1. (757 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (134 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
lig1DNA ligase. (1002 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (2776 aa)
tdrd3Tudor domain containing 3. (786 aa)
mcph1Microcephalin 1. (808 aa)
rhno1Si:ch73-352p4.5. (221 aa)
brca1Uncharacterized protein. (1344 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
ENSPREP00000033302DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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