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rad51 rad51 slf1 slf1 topbp1 topbp1 rad50 rad50 blm blm rmi2 rmi2 exd2 exd2 RPA1 RPA1 LOC103474198 LOC103474198 hus1 hus1 rbbp8 rbbp8 xrcc2 xrcc2 atr atr bard1 bard1 xrcc3 xrcc3 brca2 brca2 rpa3 rpa3 rad51c rad51c mdc1 mdc1 rad51d rad51d brip1 brip1 recql5 recql5 rad9b rad9b rad52 rad52 chek2 chek2 nbn nbn atm atm dmc1 dmc1 top3b top3b rad1 rad1 tp53bp1 tp53bp1 rad9a rad9a ENSPREP00000026167 ENSPREP00000026167 LOC103482478 LOC103482478 LOC103459742 LOC103459742 top3a top3a rmi1 rmi1 tdrd3 tdrd3 mcph1 mcph1 rhno1 rhno1 brca1 brca1 mre11 mre11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad51RAD51 recombinase. (219 aa)
slf1SMC5-SMC6 complex localization factor 1. (880 aa)
topbp1DNA topoisomerase II binding protein 1. (1453 aa)
rad50RAD50 homolog, double strand break repair protein. (1355 aa)
blmBLM RecQ like helicase. (1399 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
exd2Exonuclease 3'-5' domain containing 2. (644 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (245 aa)
rbbp8Uncharacterized protein. (647 aa)
xrcc2X-ray repair cross complementing 2. (292 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
bard1BRCA1 associated RING domain 1. (722 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa)
brca2BRCA2 DNA repair associated. (3038 aa)
rpa3Replication protein A3. (122 aa)
rad51cRAD51 paralog C. (377 aa)
mdc1Uncharacterized protein. (2088 aa)
rad51dRAD51 paralog D. (350 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1386 aa)
recql5RecQ helicase-like 5. (1020 aa)
rad9bRAD9 checkpoint clamp component B. (442 aa)
rad52RAD52 homolog, DNA repair protein. (343 aa)
chek2Checkpoint kinase 2. (510 aa)
nbnNibrin. (843 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1579 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
ENSPREP00000026167F-box DNA helicase 1. (875 aa)
LOC103482478Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa)
LOC103459742Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1019 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa)
tdrd3Tudor domain containing 3. (786 aa)
mcph1Microcephalin 1. (808 aa)
rhno1Si:ch73-352p4.5. (221 aa)
brca1Uncharacterized protein. (1344 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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