(90 nodes) Regulation of APC/C activators between G1/S and early anaphase, and Cyclin-dependent protein serine/threonine kinase regulator activity network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLK1	Serine/threonine-protein kinase PLK. (581 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (719 aa)
	anapc13	Anaphase promoting complex subunit 13. (74 aa)
	LOC103466812	Cyclin D2, a; Belongs to the cyclin family. (355 aa)
	anapc16	Anaphase promoting complex subunit 16. (108 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	anapc1	Anaphase promoting complex subunit 1. (1878 aa)
	fbxo5	F-box protein 5. (376 aa)
	LOC103477709	Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	anapc10	Anaphase promoting complex subunit 10. (184 aa)
	ccne1	Cyclin E1; Belongs to the cyclin family. (434 aa)
	cdc20	Cell division cycle 20 homolog. (555 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
	ccnj	Cyclin J; Belongs to the cyclin family. (354 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	ENSPREP00000005245	Uncharacterized protein. (189 aa)
	wee1	Wee1-like protein kinase. (620 aa)
	ccnjl	Cyclin J-like; Belongs to the cyclin family. (422 aa)
	LOC103465183	Cyclin-dependent kinase inhibitor 1A. (156 aa)
	cdk17	Cyclin dependent kinase 17. (521 aa)
	Ccnd3	Cyclin D3; Belongs to the cyclin family. (198 aa)
	ENSPREP00000007590	Cyclin I family, member 2; Belongs to the cyclin family. (339 aa)
	LOC103479019	Fizzy/cell division cycle 20 related 1b. (396 aa)
	ccng1	CYCLIN domain-containing protein; Belongs to the cyclin family. (297 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (742 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (126 aa)
	skp2	F-box domain-containing protein. (426 aa)
	LOC103471520	Cyclin-dependent kinase 15. (515 aa)
	CDC25B	Cell division cycle 25B. (383 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (308 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (434 aa)
	bub3	BUB3 mitotic checkpoint protein. (326 aa)
	nek2	NIMA-related kinase 2. (352 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (331 aa)
	ube2s	Ubiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
	LOC103469340	Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (289 aa)
	CCNO	Cyclin O; Belongs to the cyclin family. (301 aa)
	bicral	BRD4 interacting chromatin remodeling complex associated protein like. (779 aa)
	ENSPREP00000013852	Uncharacterized protein. (148 aa)
	LOC103459498	Cyclin-dependent kinase inhibitor 1D. (179 aa)
	eml5	EMAP like 5. (1941 aa)
	ccnb3	Cyclin B3; Belongs to the cyclin family. (475 aa)
	cdk14	Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily. (423 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (776 aa)
	LOC103479248	Uncharacterized protein. (537 aa)
	LOC103469079	Cyclin Dx; Belongs to the cyclin family. (295 aa)
	bora	Bora aurora kinase A activator. (556 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (402 aa)
	LOC103463560	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	LOC103465909	Cyclin-dependent kinase inhibitor 1Bb. (194 aa)
	LOC103465931	Cyclin-dependent kinase inhibitor 1Cb. (217 aa)
	cdc27	Cell division cycle 27. (803 aa)
	LOC103460235	Cyclin-dependent kinase 16; Belongs to the protein kinase superfamily. (392 aa)
	ube2e1	Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
	LOC103471961	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	ENSPREP00000021048	BUB1 N-terminal domain-containing protein. (264 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	ENSPREP00000021805	Protein kinase domain-containing protein. (70 aa)
	cdk4	Cyclin-dependent kinase 4. (228 aa)
	ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	LOC103459684	Cyclin dependent kinase 17. (528 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	bicra	BRD4 interacting chromatin remodeling complex associated protein. (1687 aa)
	eml1	EMAP like 1. (640 aa)
	ENSPREP00000024188	Uncharacterized protein. (108 aa)
	cdc26	Uncharacterized protein. (62 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	fam89a	Family with sequence similarity 89 member A. (177 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (470 aa)
	LOC103465434	Cyclin dependent kinase 18; Belongs to the protein kinase superfamily. (493 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (394 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
	LOC103467457	Protein kinase domain-containing protein. (548 aa)
	LOC103475145	EMAP like 2. (623 aa)
	LOC103464190	ANK_REP_REGION domain-containing protein. (161 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	cks1b	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
	LOC103473919	Cyclin G2; Belongs to the cyclin family. (330 aa)
	ENSPREP00000029492	ANK_REP_REGION domain-containing protein. (376 aa)
	ccnb1	Cyclin B1; Belongs to the cyclin family. (401 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	wee2	Wee1-like protein kinase. (527 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
	LOC103459164	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (575 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bub1	CCNG2	ENSPREP00000021030	ENSPREP00000011423	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin G2; Belongs to the cyclin family.	0.522
Bub1	CCNO	ENSPREP00000021030	ENSPREP00000013468	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin O; Belongs to the cyclin family.	0.522
Bub1	ENSPREP00000007590	ENSPREP00000021030	ENSPREP00000007590	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin I family, member 2; Belongs to the cyclin family.	0.522
Bub1	ENSPREP00000021048	ENSPREP00000021030	ENSPREP00000021048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 N-terminal domain-containing protein.	0.847
Bub1	ENSPREP00000021805	ENSPREP00000021030	ENSPREP00000021805	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.669
Bub1	ENSPREP00000024188	ENSPREP00000021030	ENSPREP00000024188	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.590
Bub1	ENSPREP00000029492	ENSPREP00000021030	ENSPREP00000029492	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	ANK_REP_REGION domain-containing protein.	0.522
Bub1	FZR1	ENSPREP00000021030	ENSPREP00000026428	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fizzy/cell division cycle 20 related 1a.	0.848
Bub1	LOC103459684	ENSPREP00000021030	ENSPREP00000023524	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 17.	0.527
Bub1	LOC103460235	ENSPREP00000021030	ENSPREP00000019374	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 16; Belongs to the protein kinase superfamily.	0.527
Bub1	LOC103465434	ENSPREP00000021030	ENSPREP00000026881	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 18; Belongs to the protein kinase superfamily.	0.527
Bub1	LOC103467457	ENSPREP00000021030	ENSPREP00000027760	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.527
Bub1	LOC103469340	ENSPREP00000021030	ENSPREP00000013456	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily.	0.491
Bub1	LOC103471520	ENSPREP00000021030	ENSPREP00000009039	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 15.	0.527
Bub1	LOC103471961	ENSPREP00000021030	ENSPREP00000020367	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.421
Bub1	LOC103473919	ENSPREP00000021030	ENSPREP00000029429	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin G2; Belongs to the cyclin family.	0.522
Bub1	LOC103475145	ENSPREP00000021030	ENSPREP00000027941	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	EMAP like 2.	0.590
Bub1	LOC103477709	ENSPREP00000021030	ENSPREP00000003525	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family.	0.421
Bub1	LOC103479019	ENSPREP00000021030	ENSPREP00000007608	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fizzy/cell division cycle 20 related 1b.	0.848
Bub1	PLK1	ENSPREP00000021030	ENSPREP00000000056	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.836