(39 nodes) Inactivation of APC/C via direct inhibition of the APC/C complex, and Anaphase-promoting complex binding network (Poecilia reticulata)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	mad1l1	Mitotic arrest deficient 1 like 1. (719 aa)
	anapc13	Anaphase promoting complex subunit 13. (74 aa)
	anapc16	Anaphase promoting complex subunit 16. (108 aa)
	anapc1	Anaphase promoting complex subunit 1. (1878 aa)
	fbxo5	F-box protein 5. (376 aa)
	LOC103477709	Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	anapc10	Anaphase promoting complex subunit 10. (184 aa)
	cdc20	Cell division cycle 20 homolog. (555 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	LOC103479019	Fizzy/cell division cycle 20 related 1b. (396 aa)
	ccng1	CYCLIN domain-containing protein; Belongs to the cyclin family. (297 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (742 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	bub3	BUB3 mitotic checkpoint protein. (326 aa)
	nek2	NIMA-related kinase 2. (352 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (331 aa)
	ube2s	Ubiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
	bicral	BRD4 interacting chromatin remodeling complex associated protein like. (779 aa)
	cdc27	Cell division cycle 27. (803 aa)
	ube2e1	Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
	LOC103471961	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	ENSPREP00000021048	BUB1 N-terminal domain-containing protein. (264 aa)
	ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	bicra	BRD4 interacting chromatin remodeling complex associated protein. (1687 aa)
	eml1	EMAP like 1. (640 aa)
	ENSPREP00000024188	Uncharacterized protein. (108 aa)
	cdc26	Uncharacterized protein. (62 aa)
	fam89a	Family with sequence similarity 89 member A. (177 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (470 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
	LOC103467457	Protein kinase domain-containing protein. (548 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	LOC103473919	Cyclin G2; Belongs to the cyclin family. (330 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (575 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bub1	CCNG2	ENSPREP00000021030	ENSPREP00000011423	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin G2; Belongs to the cyclin family.	0.522
Bub1	ENSPREP00000021048	ENSPREP00000021030	ENSPREP00000021048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 N-terminal domain-containing protein.	0.847
Bub1	ENSPREP00000024188	ENSPREP00000021030	ENSPREP00000024188	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.590
Bub1	FZR1	ENSPREP00000021030	ENSPREP00000026428	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fizzy/cell division cycle 20 related 1a.	0.848
Bub1	LOC103467457	ENSPREP00000021030	ENSPREP00000027760	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.527
Bub1	LOC103471961	ENSPREP00000021030	ENSPREP00000020367	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.421
Bub1	LOC103473919	ENSPREP00000021030	ENSPREP00000029429	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin G2; Belongs to the cyclin family.	0.522
Bub1	LOC103477709	ENSPREP00000021030	ENSPREP00000003525	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family.	0.421
Bub1	LOC103479019	ENSPREP00000021030	ENSPREP00000007608	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fizzy/cell division cycle 20 related 1b.	0.848
Bub1	anapc1	ENSPREP00000021030	ENSPREP00000003104	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 1.	0.941
Bub1	anapc10	ENSPREP00000021030	ENSPREP00000003892	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 10.	0.941
Bub1	anapc11	ENSPREP00000021030	ENSPREP00000004954	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC11 anaphase promoting complex subunit 11 homolog (yeast).	0.872
Bub1	anapc13	ENSPREP00000021030	ENSPREP00000001334	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 13.	0.425
Bub1	anapc15	ENSPREP00000021030	ENSPREP00000028721	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 15.	0.744
Bub1	anapc16	ENSPREP00000021030	ENSPREP00000002633	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 16.	0.765
Bub1	anapc2	ENSPREP00000021030	ENSPREP00000007853	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.934
Bub1	anapc4	ENSPREP00000021030	ENSPREP00000027724	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.935
Bub1	anapc5	ENSPREP00000021030	ENSPREP00000030371	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 5.	0.937
Bub1	anapc7	ENSPREP00000021030	ENSPREP00000023863	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 7.	0.845
Bub1	bicra	ENSPREP00000021030	ENSPREP00000024150	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BRD4 interacting chromatin remodeling complex associated protein.	0.809