(79 nodes) DNA damage checkpoint signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cep63	Centrosomal protein 63. (656 aa)
	rad9b	RAD9 checkpoint clamp component B. (442 aa)
	chek2	Checkpoint kinase 2. (510 aa)
	nbn	Nibrin. (843 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	LOC103482091	Essential meiotic structure-specific endonuclease 1. (232 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1579 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
	uimc1	Uncharacterized protein. (985 aa)
	rint1	RAD50 interactor 1. (787 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (470 aa)
	fbxo31	F-box protein 31. (585 aa)
	DONSON	Downstream neighbor of SON. (586 aa)
	foxn3	Checkpoint suppressor 1. (483 aa)
	EME2	ERCC4 domain-containing protein. (370 aa)
	ENSPREP00000027944	Reverse transcriptase domain-containing protein. (1281 aa)
	Brcc3	BRCA1/BRCA2-containing complex, subunit 3. (251 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
	ercc6	Excision repair cross-complementation group 6. (1402 aa)
	rhno1	Si:ch73-352p4.5. (221 aa)
	brca1	Uncharacterized protein. (1344 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
	hinfp	Histone H4 transcription factor. (489 aa)
	taok2	TAO kinase 2b. (1168 aa)
	LOC103479019	Fizzy/cell division cycle 20 related 1b. (396 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	cdca7	Cell division cycle associated 7a. (403 aa)
	map3k20	Uncharacterized protein. (796 aa)
	babam2	BRISC and BRCA1 A complex member 2. (386 aa)
	taok3	TAO kinase 3a. (950 aa)
	cdca7l	Cell division cycle associated 7b. (397 aa)
	LOC103478965	WW domain-containing protein. (511 aa)
	prpf19	Pre-mRNA processing factor 19. (458 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	rfwd3	Ring finger and WD repeat domain 3. (893 aa)
	e2f1	E2F transcription factor 1. (477 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1453 aa)
	ENSPREP00000007980	Reverse transcriptase domain-containing protein. (282 aa)
	ENSPREP00000008127	Reverse transcriptase domain-containing protein. (1242 aa)
	ticrr	Treslin_N domain-containing protein. (1692 aa)
	ENSPREP00000008303	Reverse transcriptase domain-containing protein. (353 aa)
	ENSPREP00000009572	Reverse transcriptase domain-containing protein. (554 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (308 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (704 aa)
	blm	BLM RecQ like helicase. (1399 aa)
	LOC103468682	Uncharacterized protein. (455 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (254 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (431 aa)
	dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1584 aa)
	ZNF830	Zinc finger protein 830. (333 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3907 aa)
	fancd2	FA complementation group D2. (1432 aa)
	LOC103475599	TAO kinase 1b. (1015 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (464 aa)
	CLSPN	Claspin. (1239 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (245 aa)
	ENSPREP00000015300	Reverse transcriptase domain-containing protein. (415 aa)
	LOC103474167	TAO kinase 1a. (1013 aa)
	rad17	RAD17 checkpoint clamp loader component. (705 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (454 aa)
	LOC103469511	TAO kinase 2. (1086 aa)
	Clg10h5orf45	Uncharacterized protein. (78 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
	pidd1	P53-induced death domain protein 1. (942 aa)
	LOC103476762	ALMS_motif domain-containing protein. (417 aa)
	LOC103474226	Zgc:112083. (510 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (349 aa)
	babam1	BRISC and BRCA1 A complex member 1. (355 aa)
	ENSPREP00000018722	Reverse transcriptase domain-containing protein. (253 aa)
	wac	WW domain containing adaptor with coiled-coil a. (543 aa)
	ENSPREP00000019024	TAO kinase 3b. (437 aa)
	ENSPREP00000019040	Uncharacterized protein. (93 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (506 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (852 aa)
	LOC103479332	Protein kinase domain-containing protein. (674 aa)
	atrip	Uncharacterized protein. (763 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (616 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brcc3	Clg10h5orf45	ENSPREP00000029026	ENSPREP00000016757	BRCA1/BRCA2-containing complex, subunit 3.	Uncharacterized protein.	0.575
Brcc3	ENSPREP00000007980	ENSPREP00000029026	ENSPREP00000007980	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	ENSPREP00000008127	ENSPREP00000029026	ENSPREP00000008127	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	ENSPREP00000008303	ENSPREP00000029026	ENSPREP00000008303	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	ENSPREP00000009572	ENSPREP00000029026	ENSPREP00000009572	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	ENSPREP00000015300	ENSPREP00000029026	ENSPREP00000015300	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	ENSPREP00000018722	ENSPREP00000029026	ENSPREP00000018722	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	ENSPREP00000027944	ENSPREP00000029026	ENSPREP00000027944	BRCA1/BRCA2-containing complex, subunit 3.	Reverse transcriptase domain-containing protein.	0.835
Brcc3	abraxas1	ENSPREP00000029026	ENSPREP00000018551	BRCA1/BRCA2-containing complex, subunit 3.	Abraxas 1, BRCA1 A complex subunit.	0.491
Brcc3	atm	ENSPREP00000029026	ENSPREP00000024388	BRCA1/BRCA2-containing complex, subunit 3.	Non-specific serine/threonine protein kinase.	0.656
Brcc3	babam1	ENSPREP00000029026	ENSPREP00000018641	BRCA1/BRCA2-containing complex, subunit 3.	BRISC and BRCA1 A complex member 1.	0.998
Brcc3	babam2	ENSPREP00000029026	ENSPREP00000006884	BRCA1/BRCA2-containing complex, subunit 3.	BRISC and BRCA1 A complex member 2.	0.998
Brcc3	brca1	ENSPREP00000029026	ENSPREP00000033076	BRCA1/BRCA2-containing complex, subunit 3.	Uncharacterized protein.	0.949
Brcc3	chek2	ENSPREP00000029026	ENSPREP00000024020	BRCA1/BRCA2-containing complex, subunit 3.	Checkpoint kinase 2.	0.625
Brcc3	dtl	ENSPREP00000029026	ENSPREP00000011102	BRCA1/BRCA2-containing complex, subunit 3.	Denticleless E3 ubiquitin protein ligase homolog (Drosophila).	0.465
Brcc3	mre11	ENSPREP00000029026	ENSPREP00000033509	BRCA1/BRCA2-containing complex, subunit 3.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.625
Brcc3	nbn	ENSPREP00000029026	ENSPREP00000024347	BRCA1/BRCA2-containing complex, subunit 3.	Nibrin.	0.650
Brcc3	tp53bp1	ENSPREP00000029026	ENSPREP00000025854	BRCA1/BRCA2-containing complex, subunit 3.	Tumor protein p53 binding protein, 1.	0.689
Brcc3	uimc1	ENSPREP00000029026	ENSPREP00000026203	BRCA1/BRCA2-containing complex, subunit 3.	Uncharacterized protein.	0.890
Brcc3	xpc	ENSPREP00000029026	ENSPREP00000019514	BRCA1/BRCA2-containing complex, subunit 3.	Xeroderma pigmentosum, complementation group C.	0.436