(52 nodes) Mitotic cytokinesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103463808	Uncharacterized protein; Belongs to the AAA ATPase family. (411 aa)
	cep55	Centrosomal protein 55 like. (500 aa)
	racgap1	Rac GTPase activating protein 1. (630 aa)
	unc119	Unc-119 lipid binding chaperone. (219 aa)
	LOC103464971	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1972 aa)
	efhc2	EF-hand domain (C-terminal) containing 2. (752 aa)
	nusap1	Nucleolar and spindle associated protein 1. (434 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1075 aa)
	LOC103476867	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (703 aa)
	LOC103465432	Kelch domain containing 8A. (247 aa)
	LOC103477214	Uncharacterized protein. (951 aa)
	LOC103460459	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (932 aa)
	LOC103469600	Citron rho-interacting serine/threonine kinase b. (1537 aa)
	jtb	Jumping translocation breakpoint. (150 aa)
	rab35	RAB35, member RAS oncogene family b. (184 aa)
	LOC103470121	Leucine zipper, putative tumor suppressor family member 3b. (1097 aa)
	LOC103473803	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (220 aa)
	LOC103471497	Aurora kinase B; Belongs to the protein kinase superfamily. (350 aa)
	anln	Anillin, actin binding protein. (1138 aa)
	ect2	Epithelial cell transforming 2. (1097 aa)
	snx33	Sorting nexin. (562 aa)
	incenp	Uncharacterized protein. (755 aa)
	LOC103466529	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (894 aa)
	lzts2	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (696 aa)
	LOC103481050	Uncharacterized protein. (530 aa)
	zfyve26	Zinc finger, FYVE domain containing 26. (2556 aa)
	SNX18	Sorting nexin. (567 aa)
	LOC103475648	Unc-119 lipid binding chaperone. (250 aa)
	mitd1	MIT, microtubule interacting and transport, domain containing 1. (180 aa)
	ENSPREP00000012632	MIT domain-containing protein. (55 aa)
	chmp4c	Charged multivesicular body protein 4C. (242 aa)
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (854 aa)
	spast	Spastin; Belongs to the AAA ATPase family. (488 aa)
	LOC103460746	Si:ch1073-416j23.1. (674 aa)
	rock1	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1263 aa)
	bbs4	Bardet-Biedl syndrome 4. (520 aa)
	LOC103461390	Uncharacterized protein. (82 aa)
	ENSPREP00000008739	NEDD4 binding protein 3. (472 aa)
	efhc1	EF-hand domain (C-terminal) containing 1. (551 aa)
	LOC103473555	Sorting nexin. (596 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (878 aa)
	LOC103460653	Si:dkey-16l2.16. (209 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
	Zfyve21	Uncharacterized protein. (74 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1049 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
	LOC103481790	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (251 aa)
	klhdc8b	Kelch domain containing 8B. (354 aa)
	vps4a	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (436 aa)
	LOC103466362	Si:dkey-30c15.10. (733 aa)
	LOC103464955	Uncharacterized protein. (628 aa)
	snx9	Sorting nexin 9b. (630 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIF23	LOC103460459	ENSPREP00000011393	ENSPREP00000026153	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.873
KIF23	LOC103460746	ENSPREP00000011393	ENSPREP00000010051	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:ch1073-416j23.1.	0.948
KIF23	LOC103464955	ENSPREP00000011393	ENSPREP00000001584	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.948
KIF23	LOC103464971	ENSPREP00000011393	ENSPREP00000031765	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.517
KIF23	LOC103466362	ENSPREP00000011393	ENSPREP00000004148	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:dkey-30c15.10.	0.733
KIF23	LOC103469600	ENSPREP00000011393	ENSPREP00000023290	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Citron rho-interacting serine/threonine kinase b.	0.517
KIF23	LOC103471497	ENSPREP00000011393	ENSPREP00000020685	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.728
KIF23	anln	ENSPREP00000011393	ENSPREP00000019385	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Anillin, actin binding protein.	0.733
KIF23	cep55	ENSPREP00000011393	ENSPREP00000033526	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Centrosomal protein 55 like.	0.767
KIF23	ect2	ENSPREP00000011393	ENSPREP00000019129	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Epithelial cell transforming 2.	0.858
KIF23	incenp	ENSPREP00000011393	ENSPREP00000017581	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.856
KIF23	nusap1	ENSPREP00000011393	ENSPREP00000027860	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Nucleolar and spindle associated protein 1.	0.728
KIF23	racgap1	ENSPREP00000011393	ENSPREP00000033308	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Rac GTPase activating protein 1.	0.948
LOC103460459	KIF23	ENSPREP00000026153	ENSPREP00000011393	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.873
LOC103460459	LOC103460746	ENSPREP00000026153	ENSPREP00000010051	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:ch1073-416j23.1.	0.694
LOC103460459	LOC103464955	ENSPREP00000026153	ENSPREP00000001584	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.694
LOC103460459	LOC103466362	ENSPREP00000026153	ENSPREP00000004148	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:dkey-30c15.10.	0.480
LOC103460459	LOC103466529	ENSPREP00000026153	ENSPREP00000016294	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.873
LOC103460459	LOC103471497	ENSPREP00000026153	ENSPREP00000020685	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.617
LOC103460459	anln	ENSPREP00000026153	ENSPREP00000019385	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Anillin, actin binding protein.	0.480