(15 nodes) Telomere maintenance via recombination network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103458344	Structural maintenance of chromosomes 6. (1086 aa)
	rad51	RAD51 recombinase. (219 aa)
	tep1	Uncharacterized protein. (2622 aa)
	smc6	Si:dkey-119f1.1. (1077 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1355 aa)
	tprkb	Tp53rk binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	xrcc3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	rad51c	RAD51 paralog C. (377 aa)
	rad51d	RAD51 paralog D. (350 aa)
	smc5	Structural maintenance of chromosomes 5. (1073 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103458344	nsmce2	ENSPREP00000025027	ENSPREP00000018674	Structural maintenance of chromosomes 6.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.976
LOC103458344	rad50	ENSPREP00000025027	ENSPREP00000008829	Structural maintenance of chromosomes 6.	RAD50 homolog, double strand break repair protein.	0.439
LOC103458344	rad51	ENSPREP00000025027	ENSPREP00000001621	Structural maintenance of chromosomes 6.	RAD51 recombinase.	0.700
LOC103458344	rad51d	ENSPREP00000025027	ENSPREP00000020832	Structural maintenance of chromosomes 6.	RAD51 paralog D.	0.564
LOC103458344	smc5	ENSPREP00000025027	ENSPREP00000033520	Structural maintenance of chromosomes 6.	Structural maintenance of chromosomes 5.	0.982
brca2	ercc1	ENSPREP00000018297	ENSPREP00000015481	BRCA2 DNA repair associated.	Excision repair cross-complementation group 1.	0.549
brca2	ercc4	ENSPREP00000018297	ENSPREP00000024474	BRCA2 DNA repair associated.	Excision repair cross-complementation group 4.	0.644
brca2	rad50	ENSPREP00000018297	ENSPREP00000008829	BRCA2 DNA repair associated.	RAD50 homolog, double strand break repair protein.	0.673
brca2	rad51	ENSPREP00000018297	ENSPREP00000001621	BRCA2 DNA repair associated.	RAD51 recombinase.	0.999
brca2	rad51c	ENSPREP00000018297	ENSPREP00000019301	BRCA2 DNA repair associated.	RAD51 paralog C.	0.960
brca2	rad51d	ENSPREP00000018297	ENSPREP00000020832	BRCA2 DNA repair associated.	RAD51 paralog D.	0.981
brca2	smc5	ENSPREP00000018297	ENSPREP00000033520	BRCA2 DNA repair associated.	Structural maintenance of chromosomes 5.	0.445
brca2	xrcc1	ENSPREP00000018297	ENSPREP00000023427	BRCA2 DNA repair associated.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.549
brca2	xrcc3	ENSPREP00000018297	ENSPREP00000017856	BRCA2 DNA repair associated.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.959
ercc1	brca2	ENSPREP00000015481	ENSPREP00000018297	Excision repair cross-complementation group 1.	BRCA2 DNA repair associated.	0.549
ercc1	ercc4	ENSPREP00000015481	ENSPREP00000024474	Excision repair cross-complementation group 1.	Excision repair cross-complementation group 4.	0.999
ercc1	rad50	ENSPREP00000015481	ENSPREP00000008829	Excision repair cross-complementation group 1.	RAD50 homolog, double strand break repair protein.	0.584
ercc1	rad51	ENSPREP00000015481	ENSPREP00000001621	Excision repair cross-complementation group 1.	RAD51 recombinase.	0.745
ercc1	rad51c	ENSPREP00000015481	ENSPREP00000019301	Excision repair cross-complementation group 1.	RAD51 paralog C.	0.574
ercc1	rad51d	ENSPREP00000015481	ENSPREP00000020832	Excision repair cross-complementation group 1.	RAD51 paralog D.	0.473