STRINGSTRING
ccne2 ccne2 telo2 telo2 tert tert rif1 rif1 pinx1 pinx1 LOC103466742 LOC103466742 nfrkb nfrkb xrcc6 xrcc6 zbtb48 zbtb48 dclre1c dclre1c LOC103467311 LOC103467311 dclre1a dclre1a mre11 mre11 smc5 smc5 dclre1b dclre1b znf827 znf827 slx4 slx4 rad51 rad51 tep1 tep1 lto1 lto1 smc6 smc6 LOC103480834 LOC103480834 stn1 stn1 dkc1 dkc1 LOC103480107 LOC103480107 LOC103475985 LOC103475985 Nhp2 Nhp2 ino80d ino80d rad50 rad50 terf2ip terf2ip ENSPREP00000010558 ENSPREP00000010558 tfpt tfpt blm blm tprkb tprkb ENSPREP00000011981 ENSPREP00000011981 pif1 pif1 rtel1 rtel1 nop10 nop10 prkdc prkdc parp3 parp3 xrcc5 xrcc5 RPA1 RPA1 LOC103474198 LOC103474198 hus1 hus1 gar1 gar1 ercc1 ercc1 uchl5 uchl5 atr atr xrcc3 xrcc3 recql4 recql4 terf2 terf2 brca2 brca2 nsmce2 nsmce2 rad51c rad51c ino80e ino80e ino80 ino80 rad51d rad51d mcrs1 mcrs1 wrap53 wrap53 xrcc1 xrcc1 fbxo4 fbxo4 nbn nbn atm atm pot1 pot1 ercc4 ercc4 LOC103458344 LOC103458344 LOC103470781 LOC103470781 terf1 terf1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ccne2Cyclin E2; Belongs to the cyclin family. (394 aa)
telo2TEL2, telomere maintenance 2, homolog (S. cerevisiae). (783 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa)
rif1Replication timing regulatory factor 1. (2323 aa)
pinx1PIN2 (TERF1) interacting telomerase inhibitor 1. (378 aa)
LOC103466742Uncharacterized protein. (442 aa)
nfrkbNuclear factor related to kappaB binding protein. (1283 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (655 aa)
zbtb48Zinc finger and BTB domain containing 48. (742 aa)
dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (576 aa)
LOC103467311Prostaglandin E synthase 3a (cytosolic). (172 aa)
dclre1aDNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (895 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
smc5Structural maintenance of chromosomes 5. (1073 aa)
dclre1bDNA cross-link repair 1B. (566 aa)
znf827Zinc finger protein 827. (1453 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1463 aa)
rad51RAD51 recombinase. (219 aa)
tep1Uncharacterized protein. (2622 aa)
lto1LTO1 maturation factor of ABCE1. (141 aa)
smc6Si:dkey-119f1.1. (1077 aa)
LOC103480834C2H2-type domain-containing protein. (698 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (363 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (553 aa)
LOC103480107Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa)
LOC103475985TERF1 (TRF1)-interacting nuclear factor 2. (560 aa)
Nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (117 aa)
ino80dINO80 complex subunit Da. (1025 aa)
rad50RAD50 homolog, double strand break repair protein. (1355 aa)
terf2ipBRCT domain-containing protein. (705 aa)
ENSPREP00000010558Prostaglandin E synthase 3b (cytosolic). (140 aa)
tfptTCF3 (E2A) fusion partner. (199 aa)
blmBLM RecQ like helicase. (1399 aa)
tprkbTp53rk binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
ENSPREP00000011981LTO1 maturation factor of ABCE1. (140 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (629 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1180 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3907 aa)
parp3Poly [ADP-ribose] polymerase. (522 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (245 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (234 aa)
ercc1Excision repair cross-complementation group 1. (358 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (339 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa)
recql4RecQ helicase-like 4. (1237 aa)
terf2HTH myb-type domain-containing protein. (635 aa)
brca2BRCA2 DNA repair associated. (3038 aa)
nsmce2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
rad51cRAD51 paralog C. (377 aa)
ino80eINO80 complex subunit E. (211 aa)
ino80INO80 complex ATPase subunit. (1484 aa)
rad51dRAD51 paralog D. (350 aa)
mcrs1Microspherule protein 1. (474 aa)
wrap53WD repeat containing, antisense to TP53. (545 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
fbxo4F-box protein 4. (361 aa)
nbnNibrin. (843 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
pot1Telo_bind domain-containing protein. (763 aa)
ercc4Excision repair cross-complementation group 4. (893 aa)
LOC103458344Structural maintenance of chromosomes 6. (1086 aa)
LOC103470781Uncharacterized protein. (224 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (367 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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