(23 nodes) Ovarian follicle development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dmc1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa)
	ptx3	Pentraxin 3, long b. (445 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (239 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (944 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	eif2b4	Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (549 aa)
	eif2b5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (699 aa)
	LOC103467753	CCAAT enhancer binding protein beta. (285 aa)
	fancg	FA complementation group G. (573 aa)
	GPR149	G protein-coupled receptor 149. (766 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (379 aa)
	scaper	S-phase cyclin A-associated protein in the ER. (1468 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	amh	Anti-Mullerian hormone. (496 aa)
	ZNF830	Zinc finger protein 830. (333 aa)
	pla2g4a	Phospholipase A2. (749 aa)
	LOC103469983	EGF-like domain-containing protein. (154 aa)
	bmp15	Bone morphogenetic protein 15. (437 aa)
	msh4	MutS homolog 4. (848 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	gas2	Growth arrest-specific 2a. (306 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103467753	LOC103473773	ENSPREP00000001687	ENSPREP00000020499	CCAAT enhancer binding protein beta.	Mothers against decapentaplegic homolog.	0.468
LOC103467753	LOC103477474	ENSPREP00000001687	ENSPREP00000022544	CCAAT enhancer binding protein beta.	Mothers against decapentaplegic homolog.	0.468
LOC103467753	SMAD4	ENSPREP00000001687	ENSPREP00000027467	CCAAT enhancer binding protein beta.	Mothers against decapentaplegic homolog.	0.468
LOC103469983	tnfaip6	ENSPREP00000013728	ENSPREP00000026284	EGF-like domain-containing protein.	Tumor necrosis factor, alpha-induced protein 6.	0.615
LOC103473773	LOC103467753	ENSPREP00000020499	ENSPREP00000001687	Mothers against decapentaplegic homolog.	CCAAT enhancer binding protein beta.	0.468
LOC103473773	LOC103477474	ENSPREP00000020499	ENSPREP00000022544	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103477474	LOC103467753	ENSPREP00000022544	ENSPREP00000001687	Mothers against decapentaplegic homolog.	CCAAT enhancer binding protein beta.	0.468
LOC103477474	LOC103473773	ENSPREP00000022544	ENSPREP00000020499	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
SMAD4	LOC103467753	ENSPREP00000027467	ENSPREP00000001687	Mothers against decapentaplegic homolog.	CCAAT enhancer binding protein beta.	0.468
amh	bmp15	ENSPREP00000013152	ENSPREP00000015246	Anti-Mullerian hormone.	Bone morphogenetic protein 15.	0.637
atm	dmc1	ENSPREP00000024388	ENSPREP00000025114	Non-specific serine/threonine protein kinase.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.832
atm	fancg	ENSPREP00000024388	ENSPREP00000002809	Non-specific serine/threonine protein kinase.	FA complementation group G.	0.471
atm	msh4	ENSPREP00000024388	ENSPREP00000016251	Non-specific serine/threonine protein kinase.	MutS homolog 4.	0.744
atm	spo11	ENSPREP00000024388	ENSPREP00000011861	Non-specific serine/threonine protein kinase.	SPO11 initiator of meiotic double stranded breaks.	0.696
bmp15	amh	ENSPREP00000015246	ENSPREP00000013152	Bone morphogenetic protein 15.	Anti-Mullerian hormone.	0.637
dmc1	atm	ENSPREP00000025114	ENSPREP00000024388	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Non-specific serine/threonine protein kinase.	0.832
dmc1	fancg	ENSPREP00000025114	ENSPREP00000002809	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	FA complementation group G.	0.427
dmc1	msh4	ENSPREP00000025114	ENSPREP00000016251	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	MutS homolog 4.	0.699
dmc1	spo11	ENSPREP00000025114	ENSPREP00000011861	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	SPO11 initiator of meiotic double stranded breaks.	0.871
eif2b4	eif2b5	ENSPREP00000028439	ENSPREP00000032163	Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family.	Eukaryotic translation initiation factor 2B, subunit 5 epsilon.	0.999