(37 nodes) Leukocyte homeostasis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103474046	Fibronectin type-III domain-containing protein. (440 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (799 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	dock10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2188 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (818 aa)
	ENSPREP00000032134	Forkhead box N1. (482 aa)
	LOC103470093	Homeobox domain-containing protein. (363 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (608 aa)
	traf3ip2	SEFIR domain-containing protein. (418 aa)
	nkx2-3	NK2 homeobox 3. (349 aa)
	LOC103473499	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	AXL	AXL receptor tyrosine kinase. (885 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (645 aa)
	ENSPREP00000026492	SEFIR domain-containing protein. (109 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1119 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	LOC103466013	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	Skil	SKI-like proto-oncogene a. (374 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	LOC103476137	Solute carrier family 37 member 4b. (450 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1110 aa)
	ppp2r3c	Protein phosphatase 2, regulatory subunit B'', gamma. (422 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	tnfrsf13b	TACI-CRD2 domain-containing protein. (308 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	LOC103462295	Zgc:153993. (263 aa)
	Bcl2l11	Uncharacterized protein. (202 aa)
	slc37a4	Solute carrier family 37 member 4a. (429 aa)
	il20rb	Fibronectin type-III domain-containing protein. (275 aa)
	camlg	Calcium modulating ligand. (281 aa)
	slc46a2	Solute carrier family 46 member 2. (516 aa)
	LOC103479168	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	gpr183	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1138 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	Bcl2l11	ENSPREP00000013021	ENSPREP00000002893	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.990
BAX	LOC103462295	ENSPREP00000013021	ENSPREP00000002464	BCL2 associated X, apoptosis regulator.	Zgc:153993.	0.988
Bcl2l11	BAX	ENSPREP00000002893	ENSPREP00000013021	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.990
Bcl2l11	LOC103462295	ENSPREP00000002893	ENSPREP00000002464	Uncharacterized protein.	Zgc:153993.	0.993
ENSPREP00000002275	LOC103466013	ENSPREP00000002275	ENSPREP00000021307	DED domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.991
ENSPREP00000002275	tnfaip3	ENSPREP00000002275	ENSPREP00000012203	DED domain-containing protein.	Tumor necrosis factor, alpha-induced protein 3.	0.662
ENSPREP00000026492	tnfaip3	ENSPREP00000026492	ENSPREP00000012203	SEFIR domain-containing protein.	Tumor necrosis factor, alpha-induced protein 3.	0.422
ENSPREP00000026492	traf3ip2	ENSPREP00000026492	ENSPREP00000030465	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.900
LOC103462295	BAX	ENSPREP00000002464	ENSPREP00000013021	Zgc:153993.	BCL2 associated X, apoptosis regulator.	0.988
LOC103462295	Bcl2l11	ENSPREP00000002464	ENSPREP00000002893	Zgc:153993.	Uncharacterized protein.	0.993
LOC103466013	ENSPREP00000002275	ENSPREP00000021307	ENSPREP00000002275	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DED domain-containing protein.	0.991
LOC103466013	tnfaip3	ENSPREP00000021307	ENSPREP00000012203	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Tumor necrosis factor, alpha-induced protein 3.	0.561
camlg	tnfrsf13b	ENSPREP00000007908	ENSPREP00000000759	Calcium modulating ligand.	TACI-CRD2 domain-containing protein.	0.754
camlg	tnfsf13b	ENSPREP00000007908	ENSPREP00000033767	Calcium modulating ligand.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.439
nf1	sos1	ENSPREP00000021407	ENSPREP00000008888	Neurofibromin 1b.	Son of sevenless homolog 1 (Drosophila).	0.476
nf1	sos2	ENSPREP00000021407	ENSPREP00000026590	Neurofibromin 1b.	Son of sevenless homolog 2 (Drosophila).	0.476
rc3h1	rc3h2	ENSPREP00000025906	ENSPREP00000013221	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.672
rc3h2	rc3h1	ENSPREP00000013221	ENSPREP00000025906	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.672
sos1	nf1	ENSPREP00000008888	ENSPREP00000021407	Son of sevenless homolog 1 (Drosophila).	Neurofibromin 1b.	0.476
sos1	sos2	ENSPREP00000008888	ENSPREP00000026590	Son of sevenless homolog 1 (Drosophila).	Son of sevenless homolog 2 (Drosophila).	0.902