(42 nodes) Epithelial to mesenchymal transition network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	hmga2	Uncharacterized protein. (115 aa)
	LOC103472014	Uncharacterized protein. (209 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	SNAI2	Snail family transcriptional repressor 2. (272 aa)
	edn1	Endothelin 1. (207 aa)
	pef1	Penta-EF-hand domain containing 1. (262 aa)
	LOC103470891	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103470892	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	rflnb	Refilin B. (204 aa)
	LOC103476970	Muscle segment homeobox 3. (212 aa)
	tasor	DUF3715 domain-containing protein. (1922 aa)
	ENSPREP00000034242	Uncharacterized protein. (694 aa)
	LOC103471340	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	TMEM100	Transmembrane protein 100. (139 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	tgfbr3	Transforming growth factor, beta receptor III. (818 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	LOC103468401	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (636 aa)
	LOC103476825	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2011 aa)
	LOC103464114	BTB domain-containing protein. (514 aa)
	LOC103478167	Ephrin-A1b; Belongs to the ephrin family. (232 aa)
	LOC103467505	Transcription activation suppressor b. (1474 aa)
	pdcd6	Programmed cell death 6. (185 aa)
	kbtbd8	Kelch repeat and BTB (POZ) domain containing 8. (604 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (636 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	Loxl4	Lysyl oxidase-like 4. (276 aa)
	ENSPREP00000028931	SRCR domain-containing protein. (199 aa)
	LOC103472698	Ephrin-A1a; Belongs to the ephrin family. (221 aa)
	LOC103467401	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	LOC103462103	Si:cabz01100188.1. (912 aa)
	LOC103464681	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (651 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	KLHL12	Kelch like family member 12. (598 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	polr1b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1134 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX5	ENSPREP00000034242	ENSPREP00000027962	ENSPREP00000034242	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.435
DDX5	LOC103468401	ENSPREP00000027962	ENSPREP00000022845	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.901
DDX5	polr1b	ENSPREP00000027962	ENSPREP00000004067	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.646
EDNRA	edn1	ENSPREP00000004362	ENSPREP00000012837	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.971
ENSPREP00000034242	DDX5	ENSPREP00000034242	ENSPREP00000027962	Uncharacterized protein.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.435
ENSPREP00000034242	LOC103464681	ENSPREP00000034242	ENSPREP00000000681	Uncharacterized protein.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.435
ENSPREP00000034242	LOC103468401	ENSPREP00000034242	ENSPREP00000022845	Uncharacterized protein.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.435
ENSPREP00000034242	kbtbd8	ENSPREP00000034242	ENSPREP00000027102	Uncharacterized protein.	Kelch repeat and BTB (POZ) domain containing 8.	0.613
ENSPREP00000034242	polr1b	ENSPREP00000034242	ENSPREP00000004067	Uncharacterized protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.879
KLHL12	kbtbd8	ENSPREP00000001750	ENSPREP00000027102	Kelch like family member 12.	Kelch repeat and BTB (POZ) domain containing 8.	0.432
KLHL12	pef1	ENSPREP00000001750	ENSPREP00000029982	Kelch like family member 12.	Penta-EF-hand domain containing 1.	0.613
LOC103464114	kbtbd8	ENSPREP00000024739	ENSPREP00000027102	BTB domain-containing protein.	Kelch repeat and BTB (POZ) domain containing 8.	0.432
LOC103464114	pef1	ENSPREP00000024739	ENSPREP00000029982	BTB domain-containing protein.	Penta-EF-hand domain containing 1.	0.461
LOC103464681	ENSPREP00000034242	ENSPREP00000000681	ENSPREP00000034242	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.435
LOC103464681	polr1b	ENSPREP00000000681	ENSPREP00000004067	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.646
LOC103467401	LOC103470891	ENSPREP00000029660	ENSPREP00000030084	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.437
LOC103467401	LOC103470892	ENSPREP00000029660	ENSPREP00000030097	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.442
LOC103467401	Wnt16	ENSPREP00000029660	ENSPREP00000028089	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.510
LOC103468401	DDX5	ENSPREP00000022845	ENSPREP00000027962	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.901
LOC103468401	ENSPREP00000034242	ENSPREP00000022845	ENSPREP00000034242	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.435