(23 nodes) Positive regulation of cytokine-mediated signaling pathway network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	ENSPREP00000005404	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (426 aa)
	LOC103471315	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (204 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	ENSPREP00000028311	Uncharacterized protein. (97 aa)
	trim44	Tripartite motif containing 44. (357 aa)
	trim32	Tripartite motif containing 32. (628 aa)
	LOC103466382	LSM14A mRNA processing body assembly factor a. (480 aa)
	gas6	Uncharacterized protein. (650 aa)
	LOC103458871	ADAM metallopeptidase domain 17a. (800 aa)
	ENSPREP00000026909	C1q domain-containing protein. (122 aa)
	tbk1	TANK-binding kinase 1. (703 aa)
	LOC103481249	Interferon regulatory factor 3. (465 aa)
	LOC103467541	Colony stimulating factor 1b (macrophage). (266 aa)
	ENSPREP00000021987	ADAM metallopeptidase domain 17b. (508 aa)
	Adam17	Pep_M12B_propep domain-containing protein. (290 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	rnf185	Ring finger protein 185. (193 aa)
	edn1	Endothelin 1. (207 aa)
	lsm14a	LSM14A mRNA processing body assembly factor b. (463 aa)
	ube2k	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
	supt5h	Transcription elongation factor SPT5. (1059 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103476623	Uncharacterized protein. (392 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	ENSPREP00000021987	ENSPREP00000021960	ENSPREP00000021987	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17b.	0.932
Adam17	LOC103458871	ENSPREP00000021960	ENSPREP00000025199	Pep_M12B_propep domain-containing protein.	ADAM metallopeptidase domain 17a.	0.902
ENSPREP00000002275	ENSPREP00000005404	ENSPREP00000002275	ENSPREP00000005404	DED domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.405
ENSPREP00000002275	ENSPREP00000020277	ENSPREP00000002275	ENSPREP00000020277	DED domain-containing protein.	RBR-type E3 ubiquitin transferase.	0.451
ENSPREP00000002275	ripk2	ENSPREP00000002275	ENSPREP00000009886	DED domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.710
ENSPREP00000002275	tbk1	ENSPREP00000002275	ENSPREP00000027853	DED domain-containing protein.	TANK-binding kinase 1.	0.405
ENSPREP00000005404	ENSPREP00000002275	ENSPREP00000005404	ENSPREP00000002275	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	DED domain-containing protein.	0.405
ENSPREP00000005404	ENSPREP00000020277	ENSPREP00000005404	ENSPREP00000020277	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	RBR-type E3 ubiquitin transferase.	0.418
ENSPREP00000005404	LOC103481249	ENSPREP00000005404	ENSPREP00000032515	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interferon regulatory factor 3.	0.911
ENSPREP00000020277	ENSPREP00000002275	ENSPREP00000020277	ENSPREP00000002275	RBR-type E3 ubiquitin transferase.	DED domain-containing protein.	0.451
ENSPREP00000020277	ENSPREP00000005404	ENSPREP00000020277	ENSPREP00000005404	RBR-type E3 ubiquitin transferase.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.418
ENSPREP00000020277	LOC103471315	ENSPREP00000020277	ENSPREP00000003043	RBR-type E3 ubiquitin transferase.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.608
ENSPREP00000020277	ripk2	ENSPREP00000020277	ENSPREP00000009886	RBR-type E3 ubiquitin transferase.	Receptor-interacting serine-threonine kinase 2.	0.460
ENSPREP00000020277	tbk1	ENSPREP00000020277	ENSPREP00000027853	RBR-type E3 ubiquitin transferase.	TANK-binding kinase 1.	0.418
ENSPREP00000020277	ube2k	ENSPREP00000020277	ENSPREP00000011256	RBR-type E3 ubiquitin transferase.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.608
ENSPREP00000021987	Adam17	ENSPREP00000021987	ENSPREP00000021960	ADAM metallopeptidase domain 17b.	Pep_M12B_propep domain-containing protein.	0.932
LOC103458871	Adam17	ENSPREP00000025199	ENSPREP00000021960	ADAM metallopeptidase domain 17a.	Pep_M12B_propep domain-containing protein.	0.902
LOC103471315	ENSPREP00000020277	ENSPREP00000003043	ENSPREP00000020277	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	RBR-type E3 ubiquitin transferase.	0.608
LOC103481249	ENSPREP00000005404	ENSPREP00000032515	ENSPREP00000005404	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.911
LOC103481249	tbk1	ENSPREP00000032515	ENSPREP00000027853	Interferon regulatory factor 3.	TANK-binding kinase 1.	0.993