(28 nodes) Somatic diversification of immune receptors via germline recombination within a single locus network (Poecilia reticulata)

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Known Interactions

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Predicted Interactions

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Your Input:
	atad5	ATPase family AAA domain containing 5a. (1822 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
	aicda	Activation-induced cytidine deaminase. (211 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3907 aa)
	pex13	Si:ch211-189k9.2. (718 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	LOC103471589	CD40 ligand; Belongs to the tumor necrosis factor family. (237 aa)
	exosc3	Exosome component 3. (273 aa)
	msh3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1117 aa)
	LOC103473172	X-ray repair complementing defective repair in Chinese hamster cells 4. (340 aa)
	nhej1	Nonhomologous end-joining factor 1. (315 aa)
	LOC103464804	LisH domain-containing protein. (1582 aa)
	ENSPREP00000022497	G_PROTEIN_RECEP_F1_2 domain-containing protein. (160 aa)
	ENSPREP00000022535	G_PROTEIN_RECEP_F1_2 domain-containing protein. (363 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1356 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (994 aa)
	rag2	Recombination activating gene 2. (533 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (124 aa)
	ENSPREP00000031399	Ring finger protein 168. (425 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (303 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1380 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (726 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	LOC103458658	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	tcf7	Transcription factor 7. (453 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	lig4	DNA ligase. (908 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCAF1	ung	ENSPREP00000025564	ENSPREP00000032770	DDB1 and CUL4 associated factor 1.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.862
ENSPREP00000031399	atm	ENSPREP00000031399	ENSPREP00000024388	Ring finger protein 168.	Non-specific serine/threonine protein kinase.	0.806
ENSPREP00000031399	prkdc	ENSPREP00000031399	ENSPREP00000013864	Ring finger protein 168.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.758
ENSPREP00000031399	rnf8	ENSPREP00000031399	ENSPREP00000012303	Ring finger protein 168.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.852
LOC103464804	ung	ENSPREP00000022084	ENSPREP00000032770	LisH domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.862
LOC103471589	aicda	ENSPREP00000015614	ENSPREP00000013314	CD40 ligand; Belongs to the tumor necrosis factor family.	Activation-induced cytidine deaminase.	0.549
LOC103473172	lig4	ENSPREP00000020178	ENSPREP00000010705	X-ray repair complementing defective repair in Chinese hamster cells 4.	DNA ligase.	0.867
LOC103473172	nhej1	ENSPREP00000020178	ENSPREP00000021799	X-ray repair complementing defective repair in Chinese hamster cells 4.	Nonhomologous end-joining factor 1.	0.737
LOC103473172	prkdc	ENSPREP00000020178	ENSPREP00000013864	X-ray repair complementing defective repair in Chinese hamster cells 4.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.707
aicda	LOC103471589	ENSPREP00000013314	ENSPREP00000015614	Activation-induced cytidine deaminase.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.549
aicda	msh6	ENSPREP00000013314	ENSPREP00000034111	Activation-induced cytidine deaminase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.407
aicda	rag1	ENSPREP00000013314	ENSPREP00000028083	Activation-induced cytidine deaminase.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.514
aicda	rag2	ENSPREP00000013314	ENSPREP00000028094	Activation-induced cytidine deaminase.	Recombination activating gene 2.	0.437
aicda	ung	ENSPREP00000013314	ENSPREP00000032770	Activation-induced cytidine deaminase.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.620
atad5	atm	ENSPREP00000001791	ENSPREP00000024388	ATPase family AAA domain containing 5a.	Non-specific serine/threonine protein kinase.	0.659
atad5	lig4	ENSPREP00000001791	ENSPREP00000010705	ATPase family AAA domain containing 5a.	DNA ligase.	0.688
atad5	msh2	ENSPREP00000001791	ENSPREP00000007571	ATPase family AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.455
atad5	msh3	ENSPREP00000001791	ENSPREP00000018450	ATPase family AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.416
atad5	msh6	ENSPREP00000001791	ENSPREP00000034111	ATPase family AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.540
atm	ENSPREP00000031399	ENSPREP00000024388	ENSPREP00000031399	Non-specific serine/threonine protein kinase.	Ring finger protein 168.	0.806