(14 nodes) Type B pancreatic cell differentiation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103470081	Hcy-binding domain-containing protein. (435 aa)
	LOC103458622	Insulinoma-associated 1b. (414 aa)
	ENSPREP00000003163	Paired box 4. (287 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	LOC103465784	Uncharacterized protein. (393 aa)
	CDKAL1	CDK5 regulatory subunit associated protein 1 like 1. (546 aa)
	LOC103470080	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (397 aa)
	pax6	Paired box 6b. (431 aa)
	LOC103476384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (79 aa)
	rfx6	Regulatory factor X, 6. (831 aa)
	LOC103473309	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (397 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	Fitm2	Fat storage inducing transmembrane protein 2. (250 aa)
	ENSPREP00000030771	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (65 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000003163	pdx1	ENSPREP00000003163	ENSPREP00000028858	Paired box 4.	Pancreatic and duodenal homeobox 1.	0.467
ENSPREP00000030771	pdx1	ENSPREP00000030771	ENSPREP00000028858	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.633
ENSPREP00000030771	rfx6	ENSPREP00000030771	ENSPREP00000026416	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.513
LOC103465784	pdx1	ENSPREP00000010500	ENSPREP00000028858	Uncharacterized protein.	Pancreatic and duodenal homeobox 1.	0.467
LOC103470080	LOC103470081	ENSPREP00000019019	ENSPREP00000019002	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	Hcy-binding domain-containing protein.	0.900
LOC103470080	LOC103473309	ENSPREP00000019019	ENSPREP00000028249	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism.	0.900
LOC103470081	LOC103470080	ENSPREP00000019002	ENSPREP00000019019	Hcy-binding domain-containing protein.	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	0.900
LOC103470081	LOC103473309	ENSPREP00000019002	ENSPREP00000028249	Hcy-binding domain-containing protein.	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism.	0.900
LOC103473309	LOC103470080	ENSPREP00000028249	ENSPREP00000019019	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism.	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	0.900
LOC103473309	LOC103470081	ENSPREP00000028249	ENSPREP00000019002	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism.	Hcy-binding domain-containing protein.	0.900
LOC103476384	pdx1	ENSPREP00000025882	ENSPREP00000028858	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.633
LOC103476384	rfx6	ENSPREP00000025882	ENSPREP00000026416	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.513
pax6	pdx1	ENSPREP00000020481	ENSPREP00000028858	Paired box 6b.	Pancreatic and duodenal homeobox 1.	0.467
pdx1	ENSPREP00000003163	ENSPREP00000028858	ENSPREP00000003163	Pancreatic and duodenal homeobox 1.	Paired box 4.	0.467
pdx1	ENSPREP00000030771	ENSPREP00000028858	ENSPREP00000030771	Pancreatic and duodenal homeobox 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.633
pdx1	LOC103465784	ENSPREP00000028858	ENSPREP00000010500	Pancreatic and duodenal homeobox 1.	Uncharacterized protein.	0.467
pdx1	LOC103476384	ENSPREP00000028858	ENSPREP00000025882	Pancreatic and duodenal homeobox 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.633
pdx1	pax6	ENSPREP00000028858	ENSPREP00000020481	Pancreatic and duodenal homeobox 1.	Paired box 6b.	0.467
rfx6	ENSPREP00000030771	ENSPREP00000026416	ENSPREP00000030771	Regulatory factor X, 6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.513
rfx6	LOC103476384	ENSPREP00000026416	ENSPREP00000025882	Regulatory factor X, 6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.513