(10 nodes) Secondary lysosome network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (888 aa)
	cln3	Battenin. (480 aa)
	plekhm1	Pleckstrin homology domain containing, family M (with RUN domain) member 1. (1080 aa)
	sqstm1	Sequestosome 1. (500 aa)
	lamp2	Lysosomal-associated membrane protein 2. (411 aa)
	LOC103470076	Uncharacterized protein. (381 aa)
	ncoa4	Nuclear receptor coactivator 4. (561 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	lamp1	Lysosomal associated membrane protein 1a. (409 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
lamp1	lamp2	ENSPREP00000031762	ENSPREP00000017886	Lysosomal associated membrane protein 1a.	Lysosomal-associated membrane protein 2.	0.932
lamp1	sqstm1	ENSPREP00000031762	ENSPREP00000016733	Lysosomal associated membrane protein 1a.	Sequestosome 1.	0.488
lamp2	lamp1	ENSPREP00000017886	ENSPREP00000031762	Lysosomal-associated membrane protein 2.	Lysosomal associated membrane protein 1a.	0.932
lamp2	sqstm1	ENSPREP00000017886	ENSPREP00000016733	Lysosomal-associated membrane protein 2.	Sequestosome 1.	0.421
pik3c3	plekhm1	ENSPREP00000005530	ENSPREP00000016533	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Pleckstrin homology domain containing, family M (with RUN domain) member 1.	0.553
pik3c3	sqstm1	ENSPREP00000005530	ENSPREP00000016733	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Sequestosome 1.	0.435
plekhm1	pik3c3	ENSPREP00000016533	ENSPREP00000005530	Pleckstrin homology domain containing, family M (with RUN domain) member 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.553
sqstm1	lamp1	ENSPREP00000016733	ENSPREP00000031762	Sequestosome 1.	Lysosomal associated membrane protein 1a.	0.488
sqstm1	lamp2	ENSPREP00000016733	ENSPREP00000017886	Sequestosome 1.	Lysosomal-associated membrane protein 2.	0.421
sqstm1	pik3c3	ENSPREP00000016733	ENSPREP00000005530	Sequestosome 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.435