(115 nodes) Bicellular tight junction network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	esam	Endothelial cell adhesion molecule a. (449 aa)
	LOC103480976	Uncharacterized protein. (750 aa)
	ENSPREP00000000467	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	CLDN20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	ENSPREP00000002240	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (76 aa)
	nphp1	Nephronophthisis 1. (698 aa)
	cldn10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	ENSPREP00000003364	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (133 aa)
	LOC103479614	Angiomotin like 2b. (698 aa)
	cyth1	Cytohesin 1a. (414 aa)
	LOC103478964	Uncharacterized protein; Belongs to the MAGUK family. (613 aa)
	LOC103464890	Uncharacterized protein. (465 aa)
	LOC103475300	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
	ENSPREP00000004879	Matrix-remodelling associated 8b. (420 aa)
	tbcd	Tubulin folding cofactor D. (1231 aa)
	LOC103481821	Cytohesin 1b. (420 aa)
	LOC103468796	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	Pard6b	Par-6 partitioning defective 6 homolog beta (C. elegans). (408 aa)
	clmp	Uncharacterized protein. (385 aa)
	ENSPREP00000006660	Uncharacterized protein. (540 aa)
	ENSPREP00000006767	Uncharacterized protein. (705 aa)
	frmd4b	FERM domain containing 4Bb. (986 aa)
	lin7b	L27 domain-containing protein. (226 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (878 aa)
	ENSPREP00000008469	Uncharacterized protein. (312 aa)
	LOC103473567	Claudin 23a. (257 aa)
	PARD3	Par-3 family cell polarity regulator. (1383 aa)
	LOC103465768	Par-6 family cell polarity regulator alpha. (420 aa)
	tjp2	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1077 aa)
	CYTH3	Cytohesin 3. (394 aa)
	tjp3	Tight junction protein 3; Belongs to the MAGUK family. (1306 aa)
	LOC103476642	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)
	LOC103479092	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	cyth2	Cytohesin 2. (405 aa)
	pard6g	Par-6 family cell polarity regulator gamma b. (453 aa)
	mtdh	Metadherin a. (519 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	LOC103479150	Zgc:154006. (550 aa)
	ENSPREP00000013704	Uncharacterized protein. (155 aa)
	LOC103463410	Si:ch211-191a24.4. (289 aa)
	ENSPREP00000013716	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (112 aa)
	LOC103460864	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	ENSPREP00000013809	Claudin b. (126 aa)
	ENSPREP00000013822	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (188 aa)
	ENSPREP00000013895	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (173 aa)
	LOC103475617	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (205 aa)
	cxadr	CXADR Ig-like cell adhesion molecule. (382 aa)
	ildr2	Immunoglobulin-like domain containing receptor 2. (541 aa)
	jam2	Junctional adhesion molecule 2a. (352 aa)
	ENSPREP00000015306	Ig-like domain-containing protein. (307 aa)
	MPDZ	Si:dkey-92j12.5. (1912 aa)
	cldn11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
	jam3	Junctional adhesion molecule 3a. (306 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	LOC103476216	Junctional adhesion molecule 3b. (302 aa)
	LOC103470677	MARVEL domain containing 2b. (556 aa)
	LOC103463288	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (548 aa)
	mpp7	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family. (576 aa)
	LOC103458410	Claudin 11a. (219 aa)
	ect2	Epithelial cell transforming 2. (1097 aa)
	Cldn14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (187 aa)
	ENSPREP00000019404	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (145 aa)
	LOC103474412	Si:busm1-52i16.2. (345 aa)
	ENSPREP00000019614	Uncharacterized protein. (181 aa)
	tjap1	Tight junction associated protein 1 (peripheral). (601 aa)
	ENSPREP00000020060	Uncharacterized protein. (361 aa)
	ENSPREP00000020115	Membrane associated guanylate kinase, WW and PDZ domain containing 3b. (711 aa)
	ENSPREP00000020159	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
	pof1b	POF1B actin binding protein. (570 aa)
	ENSPREP00000020177	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (257 aa)
	Cldn2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (195 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	frmd4a	FERM domain containing 4A. (1097 aa)
	ENSPREP00000022750	Ig-like domain-containing protein. (183 aa)
	LOC103464131	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (203 aa)
	LOC103466442	Tight junction protein 1b; Belongs to the MAGUK family. (1954 aa)
	LOC103480588	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	amotl2	Angiomotin like 2a. (697 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (894 aa)
	LOC103467539	Membrane associated guanylate kinase, WW and PDZ domain containing 1a. (1234 aa)
	LOC103473228	MARVEL domain containing 2a. (563 aa)
	LOC103473229	Occludin a. (496 aa)
	ENSPREP00000024586	Angiomotin. (962 aa)
	LOC103466075	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	LOC103478193	Uncharacterized protein. (433 aa)
	LOC103478155	Cingulin a. (1200 aa)
	ENSPREP00000025381	Rho-GAP domain-containing protein. (127 aa)
	ccdc85c	Coiled-coil domain containing 85C. (401 aa)
	rab13	RAB13, member RAS oncogene family. (216 aa)
	MPDZ-2	Multiple PDZ domain crumbs cell polarity complex component. (2132 aa)
	ENSPREP00000026663	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	cldn34	Claudin 34. (198 aa)
	LOC103475125	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (247 aa)
	ENSPREP00000027294	Uncharacterized protein. (117 aa)
	magi1	Membrane associated guanylate kinase, WW and PDZ domain containing 1b. (1691 aa)
	pard3	Par-3 family cell polarity regulator alpha, b. (1384 aa)
	ENSPREP00000027521	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (147 aa)
	ENSPREP00000027565	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	ENSPREP00000027691	Uncharacterized protein. (171 aa)
	ENSPREP00000027703	Uncharacterized protein. (161 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	LOC103458849	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	LOC103472710	Cingulin b. (1169 aa)
	LOC103462021	Ig-like domain-containing protein. (538 aa)
	LOC103481978	Uncharacterized protein. (394 aa)
	frmpd2	FERM and PDZ domain containing 2. (1149 aa)
	LOC103465525	FERM domain containing 4Ba. (1071 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1287 aa)
	c1qtnf5	C1q and TNF related 5. (250 aa)
	LOC103467810	Uncharacterized protein. (1452 aa)
	lin7a	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (225 aa)
	lin7c	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (201 aa)
	LOC103475799	F11 receptor, tandem duplicate 1. (308 aa)
	LOC103462420	Tight junction protein 1a; Belongs to the MAGUK family. (1693 aa)
	cgnl1	Cingulin-like 1. (1279 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	LOC103472710	ENSPREP00000023681	ENSPREP00000029212	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Cingulin b.	0.958
ARHGEF2	LOC103478155	ENSPREP00000023681	ENSPREP00000025082	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Cingulin a.	0.958
ARHGEF2	cgnl1	ENSPREP00000023681	ENSPREP00000034334	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Cingulin-like 1.	0.549
CLDN20	Cldn14	ENSPREP00000000801	ENSPREP00000019367	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.671
CLDN20	Cldn2	ENSPREP00000000801	ENSPREP00000020370	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.665
CLDN20	Cldn5	ENSPREP00000000801	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.665
CLDN20	ENSPREP00000003364	ENSPREP00000000801	ENSPREP00000003364	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.662
CLDN20	ENSPREP00000008469	ENSPREP00000000801	ENSPREP00000008469	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.663
CLDN20	ENSPREP00000013716	ENSPREP00000000801	ENSPREP00000013716	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	ENSPREP00000013809	ENSPREP00000000801	ENSPREP00000013809	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin b.	0.657
CLDN20	ENSPREP00000013895	ENSPREP00000000801	ENSPREP00000013895	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	ENSPREP00000019404	ENSPREP00000000801	ENSPREP00000019404	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.662
CLDN20	ENSPREP00000020159	ENSPREP00000000801	ENSPREP00000020159	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.692
CLDN20	ENSPREP00000026663	ENSPREP00000000801	ENSPREP00000026663	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.659
CLDN20	ENSPREP00000027294	ENSPREP00000000801	ENSPREP00000027294	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.656
CLDN20	ENSPREP00000027521	ENSPREP00000000801	ENSPREP00000027521	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	ENSPREP00000027565	ENSPREP00000000801	ENSPREP00000027565	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	ENSPREP00000027703	ENSPREP00000000801	ENSPREP00000027703	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.735
CLDN20	LOC103458410	ENSPREP00000000801	ENSPREP00000018934	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 11a.	0.669
CLDN20	LOC103458849	ENSPREP00000000801	ENSPREP00000029132	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650