(20 nodes) Mitotic recombination network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
	rad51c	RAD51 paralog C. (377 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	msh3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1117 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	xrcc3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (302 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	tprkb	Tp53rk binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1355 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	ENSPREP00000006911	Uncharacterized protein. (216 aa)
	smc6	Si:dkey-119f1.1. (1077 aa)
	tep1	Uncharacterized protein. (2622 aa)
	rad51	RAD51 recombinase. (219 aa)
	smc5	Structural maintenance of chromosomes 5. (1073 aa)
	dmc1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa)
	LOC103458344	Structural maintenance of chromosomes 6. (1086 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	rad52	RAD52 homolog, DNA repair protein. (343 aa)
	rad51d	RAD51 paralog D. (350 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006911	brca2	ENSPREP00000006911	ENSPREP00000018297	Uncharacterized protein.	BRCA2 DNA repair associated.	0.660
ENSPREP00000006911	dmc1	ENSPREP00000006911	ENSPREP00000025114	Uncharacterized protein.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.669
ENSPREP00000006911	ercc1	ENSPREP00000006911	ENSPREP00000015481	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.619
ENSPREP00000006911	ercc4	ENSPREP00000006911	ENSPREP00000024474	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.667
ENSPREP00000006911	msh2	ENSPREP00000006911	ENSPREP00000007571	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.644
ENSPREP00000006911	msh3	ENSPREP00000006911	ENSPREP00000018450	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.644
ENSPREP00000006911	rad50	ENSPREP00000006911	ENSPREP00000008829	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.766
ENSPREP00000006911	rad51	ENSPREP00000006911	ENSPREP00000001621	Uncharacterized protein.	RAD51 recombinase.	0.764
ENSPREP00000006911	rad51c	ENSPREP00000006911	ENSPREP00000019301	Uncharacterized protein.	RAD51 paralog C.	0.705
ENSPREP00000006911	rad51d	ENSPREP00000006911	ENSPREP00000020832	Uncharacterized protein.	RAD51 paralog D.	0.670
ENSPREP00000006911	rad52	ENSPREP00000006911	ENSPREP00000023884	Uncharacterized protein.	RAD52 homolog, DNA repair protein.	0.705
ENSPREP00000006911	xrcc1	ENSPREP00000006911	ENSPREP00000023427	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.604
ENSPREP00000006911	xrcc3	ENSPREP00000006911	ENSPREP00000017856	Uncharacterized protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.705
LOC103458344	nsmce2	ENSPREP00000025027	ENSPREP00000018674	Structural maintenance of chromosomes 6.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.976
LOC103458344	rad50	ENSPREP00000025027	ENSPREP00000008829	Structural maintenance of chromosomes 6.	RAD50 homolog, double strand break repair protein.	0.439
LOC103458344	rad51	ENSPREP00000025027	ENSPREP00000001621	Structural maintenance of chromosomes 6.	RAD51 recombinase.	0.700
LOC103458344	rad51d	ENSPREP00000025027	ENSPREP00000020832	Structural maintenance of chromosomes 6.	RAD51 paralog D.	0.564
LOC103458344	rad52	ENSPREP00000025027	ENSPREP00000023884	Structural maintenance of chromosomes 6.	RAD52 homolog, DNA repair protein.	0.593
LOC103458344	smc5	ENSPREP00000025027	ENSPREP00000033520	Structural maintenance of chromosomes 6.	Structural maintenance of chromosomes 5.	0.982
brca2	ENSPREP00000006911	ENSPREP00000018297	ENSPREP00000006911	BRCA2 DNA repair associated.	Uncharacterized protein.	0.660