STRINGSTRING
LOC103471340 LOC103471340 LOC103477731 LOC103477731 LOC103464485 LOC103464485 LOC103465458 LOC103465458 PRDX2 PRDX2 tat tat gpx7 gpx7 ankrd1 ankrd1 ndufs2 ndufs2 srxn1 srxn1 parp1 parp1 znf277 znf277 ucp1 ucp1 LOC103481448 LOC103481448 LOC103475867 LOC103475867 LOC103462295 LOC103462295 prdx3 prdx3 ENSPREP00000002835 ENSPREP00000002835 LOC103473446 LOC103473446 TPO TPO LOC103468854 LOC103468854 psip1 psip1 AIF1 AIF1 LOC103462256 LOC103462256 smpd3 smpd3 sirt1 sirt1 LOC103477101 LOC103477101 ccs ccs EDNRA EDNRA PNPT1 PNPT1 pyroxd1 pyroxd1 pxdn pxdn lrrk2 lrrk2 ENSPREP00000005402 ENSPREP00000005402 LOC103471253 LOC103471253 LOC103460601 LOC103460601 bcl2 bcl2 LOC103471076 LOC103471076 ENSPREP00000006501 ENSPREP00000006501 LOC103479005 LOC103479005 Sod3 Sod3 arl6ip5 arl6ip5 apopt1 apopt1 mtf1 mtf1 nfe2l2 nfe2l2 zc3h12a zc3h12a sod2 sod2 park7 park7 LOC103458062 LOC103458062 ENSPREP00000009104 ENSPREP00000009104 ENSPREP00000009126 ENSPREP00000009126 LOC103479635 LOC103479635 GPX4 GPX4 LOC103461430 LOC103461430 slc4a11 slc4a11 LOC103469906 LOC103469906 ENSPREP00000010125 ENSPREP00000010125 tmem161a tmem161a adnp2 adnp2 vkorc1l1 vkorc1l1 aqp1 aqp1 ENSPREP00000010780 ENSPREP00000010780 stk25 stk25 ppargc1b ppargc1b sp1 sp1 pnkp pnkp etfdh etfdh tnfaip3 tnfaip3 LOC103474128 LOC103474128 LOC103474136 LOC103474136 edn1 edn1 sirt2 sirt2 fosl1 fosl1 ptgs2 ptgs2 gpx8 gpx8 naprt naprt ankzf1 ankzf1 LOC103461755 LOC103461755 ENSPREP00000014094 ENSPREP00000014094 fancd2 fancd2 neil1 neil1 LOC103465223 LOC103465223 ENSPREP00000014421 ENSPREP00000014421 ENSPREP00000014507 ENSPREP00000014507 LOC103467077 LOC103467077 trpm2 trpm2 LOC103458467 LOC103458467 ercc1 ercc1 glrx2 glrx2 myef2 myef2 brf2 brf2 prdx5 prdx5 mgst1 mgst1 fxn fxn LOC103480673 LOC103480673 sod1 sod1 ect2 ect2 LOC103479268 LOC103479268 ENSPREP00000019286 ENSPREP00000019286 ncoa7 ncoa7 SLC4A11 SLC4A11 mapk1 mapk1 LOC103466494 LOC103466494 gclm gclm ENSPREP00000020034 ENSPREP00000020034 ENSPREP00000020277 ENSPREP00000020277 LOC103479802 LOC103479802 gsr gsr keap1 keap1 stk24 stk24 LOC103461746 LOC103461746 txn2 txn2 ERMP1 ERMP1 LOC103466013 LOC103466013 kdm6b kdm6b ENSPREP00000022126 ENSPREP00000022126 als2 als2 msrb2 msrb2 LOC103469111 LOC103469111 duox1 duox1 plekha1 plekha1 LOC103479358 LOC103479358 ENSPREP00000023207 ENSPREP00000023207 xrcc1 xrcc1 pjvk pjvk rad52 rad52 oxr1 oxr1 ogg1 ogg1 ndufa6 ndufa6 ENSPREP00000024873 ENSPREP00000024873 fancc fancc RBPMS RBPMS ube3a ube3a LOC108166662 LOC108166662 LOC103475461 LOC103475461 ncf1 ncf1 ercc8 ercc8 etv5 etv5 msrb3 msrb3 UBE3A UBE3A LOC103479917 LOC103479917 trpa1 trpa1 msra msra ucn ucn tp53inp1 tp53inp1 cpeb2 cpeb2 rwdd1 rwdd1 txnrd2 txnrd2 Wnt16 Wnt16 ppargc1a ppargc1a ercc2 ercc2 LOC103458858 LOC103458858 thg1l thg1l GPX2 GPX2 prdx4 prdx4 txnip txnip NCOA7 NCOA7 idh1 idh1 ENSPREP00000030126 ENSPREP00000030126 ENSPREP00000030210 ENSPREP00000030210 impact impact znf622 znf622 nox5 nox5 lonp1 lonp1 ENSPREP00000030584 ENSPREP00000030584 LOC103475853 LOC103475853 dhcr24 dhcr24 romo1 romo1 prkaa2 prkaa2 LOC103464252 LOC103464252 LOC103466212 LOC103466212 LOC103475730 LOC103475730 ercc6 ercc6 ENSPREP00000031687 ENSPREP00000031687 LOC103465524 LOC103465524 EPX EPX oser1 oser1 prkaa1 prkaa1 NDUFS8 NDUFS8 gclc gclc pink1 pink1 HDGFL3 HDGFL3 LOC103459124 LOC103459124 slc25a24 slc25a24 ndufa12 ndufa12 LOC103456761 LOC103456761 LOC103475891 LOC103475891 mapk7 mapk7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103471340Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (440 aa)
LOC103477731Activating transcription factor 4a. (424 aa)
LOC103464485Heme oxygenase 2a. (365 aa)
LOC103465458Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (324 aa)
PRDX2Peroxiredoxin 2. (197 aa)
tatTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (449 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (176 aa)
ankrd1Ankyrin repeat domain 1a (cardiac muscle). (302 aa)
ndufs2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (467 aa)
srxn1Sulfiredoxin. (149 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
znf277Zinc finger protein 277. (445 aa)
ucp1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
LOC103481448Glutathione peroxidase; Belongs to the glutathione peroxidase family. (134 aa)
LOC103475867Lysine (K)-specific demethylase 6B, b. (1729 aa)
LOC103462295Zgc:153993. (263 aa)
prdx3Peroxiredoxin 3. (248 aa)
ENSPREP00000002835Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (282 aa)
LOC103473446Prostaglandin-endoperoxide synthase 1. (595 aa)
TPOThyroid peroxidase. (522 aa)
LOC103468854Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (339 aa)
psip1LEDGF domain-containing protein. (392 aa)
AIF1Allograft inflammatory factor 1. (149 aa)
LOC103462256Si:ch211-260e23.8. (141 aa)
smpd3Sphingomyelin phosphodiesterase 3, neutral. (719 aa)
sirt1Sirtuin 1. (677 aa)
LOC103477101Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (536 aa)
ccsCopper chaperone for superoxide dismutase. (257 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (728 aa)
pyroxd1Pyridine nucleotide-disulphide oxidoreductase domain 1. (500 aa)
pxdnPeroxidasin. (1463 aa)
lrrk2Leucine-rich repeat kinase 2. (2573 aa)
ENSPREP00000005402Glutathione peroxidase; Belongs to the glutathione peroxidase family. (143 aa)
LOC103471253Mitogen-activated protein kinase. (420 aa)
LOC103460601Heme oxygenase 2b. (316 aa)
bcl2BCL2 apoptosis regulator b. (230 aa)
LOC103471076Uncharacterized protein. (136 aa)
ENSPREP00000006501Uncharacterized protein. (235 aa)
LOC103479005Peroxiredoxin 1. (250 aa)
Sod3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (216 aa)
arl6ip5PRA1 family protein. (190 aa)
apopt1Cytochrome c oxidase assembly factor 8. (195 aa)
mtf1Metal-regulatory transcription factor 1. (804 aa)
nfe2l2Nuclear factor, erythroid 2-like 2a. (617 aa)
zc3h12aZinc finger CCCH-type containing 12A. (623 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa)
park7Parkinson protein 7. (189 aa)
LOC103458062Serine/threonine kinase 24. (437 aa)
ENSPREP00000009104Glutathione peroxidase; Belongs to the glutathione peroxidase family. (135 aa)
ENSPREP00000009126Uncharacterized protein. (93 aa)
LOC103479635Death domain-containing protein. (536 aa)
GPX4Glutathione peroxidase 4. (144 aa)
LOC103461430Uncharacterized protein. (251 aa)
slc4a11Solute carrier family 4 member 11. (855 aa)
LOC103469906Prostaglandin-endoperoxide synthase 1. (593 aa)
ENSPREP00000010125BZIP domain-containing protein. (372 aa)
tmem161aTransmembrane protein 161A. (496 aa)
adnp2ADNP homeobox 2b. (1014 aa)
vkorc1l1Vitamin K epoxide reductase complex, subunit 1-like 1. (175 aa)
aqp1Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
ENSPREP00000010780Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (176 aa)
stk25Serine/threonine kinase 25b. (428 aa)
ppargc1bPeroxisome proliferator-activated receptor gamma, coactivator 1 beta. (929 aa)
sp1Sp1 transcription factor. (593 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (593 aa)
etfdhElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (622 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (799 aa)
LOC103474128Diablo, IAP-binding mitochondrial protein a. (233 aa)
LOC103474136Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
edn1Endothelin 1. (207 aa)
sirt2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
fosl1FOS-like antigen 1a. (336 aa)
ptgs2Prostaglandin-endoperoxide synthase 2b. (615 aa)
gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
naprtNicotinate phosphoribosyltransferase. (608 aa)
ankzf1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (736 aa)
LOC103461755NME/NM23 family member 8; Belongs to the NDK family. (491 aa)
ENSPREP00000014094NDK domain-containing protein. (133 aa)
fancd2FA complementation group D2. (1432 aa)
neil1Nei-like DNA glycosylase 1. (415 aa)
LOC103465223Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
ENSPREP00000014421Uncharacterized protein. (307 aa)
ENSPREP00000014507UBA_6 domain-containing protein. (200 aa)
LOC103467077Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1132 aa)
trpm2Transient receptor potential cation channel, subfamily M, member 2. (1460 aa)
LOC103458467Kelch-like ECH-associated protein 1a. (590 aa)
ercc1Excision repair cross-complementation group 1. (358 aa)
glrx2Glutaredoxin 2. (169 aa)
myef2Myelin expression factor 2. (546 aa)
brf2BRF2 RNA polymerase III transcription initiation factor subunit. (443 aa)
prdx5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (189 aa)
mgst1Microsomal glutathione S-transferase 1.2. (151 aa)
fxnFrataxin. (213 aa)
LOC103480673Serine/threonine protein kinase 26. (472 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
ect2Epithelial cell transforming 2. (1097 aa)
LOC103479268Glutathione peroxidase 4b. (179 aa)
ENSPREP00000019286TLDc domain-containing protein. (194 aa)
ncoa7TLDc domain-containing protein. (241 aa)
SLC4A11Solute carrier family 4 member 11. (852 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
LOC103466494Eosinophil peroxidase. (881 aa)
gclmGlutamate-cysteine ligase, modifier subunit. (281 aa)
ENSPREP00000020034JunE proto-oncogene, AP-1 transcription factor subunit. (310 aa)
ENSPREP00000020277RBR-type E3 ubiquitin transferase. (158 aa)
LOC103479802Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
gsrGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (503 aa)
keap1Kelch-like ECH-associated protein 1b. (613 aa)
stk24Serine/threonine kinase 24b (STE20 homolog, yeast). (432 aa)
LOC103461746PH domain-containing protein. (1483 aa)
txn2Thioredoxin 2. (168 aa)
ERMP1Endoplasmic reticulum metallopeptidase 1. (824 aa)
LOC103466013Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
kdm6bLysine (K)-specific demethylase 6B, a. (2105 aa)
ENSPREP00000022126Ion_trans domain-containing protein. (272 aa)
als2Alsin Rho guanine nucleotide exchange factor ALS2 b. (1671 aa)
msrb2Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (190 aa)
LOC103469111Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
duox1Dual oxidase. (1514 aa)
plekha1Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b. (333 aa)
LOC103479358Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (493 aa)
ENSPREP00000023207LSDAT_euk domain-containing protein. (146 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
pjvkPejvakin. (356 aa)
rad52RAD52 homolog, DNA repair protein. (343 aa)
oxr1Oxidation resistance 1. (841 aa)
ogg18-oxoguanine DNA glycosylase. (388 aa)
ndufa6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
ENSPREP00000024873Si:dkey-34f9.3. (139 aa)
fanccFA complementation group C. (596 aa)
RBPMSRNA binding protein, mRNA processing factor. (267 aa)
ube3aUbiquitin protein ligase E3A. (823 aa)
LOC108166662Uncharacterized protein. (191 aa)
LOC103475461Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (164 aa)
ncf1Neutrophil cytosolic factor 1. (438 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
etv5Ets variant 5a. (517 aa)
msrb3Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (167 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (944 aa)
LOC103479917Solute carrier family 25 member 24, like; Belongs to the mitochondrial carrier (TC 2.A.29) family. (445 aa)
trpa1Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
msraMethionine sulfoxide reductase A. (235 aa)
ucnUrotensin 1. (147 aa)
tp53inp1Tumor protein p53 inducible nuclear protein 1. (298 aa)
cpeb2Cytoplasmic polyadenylation element binding protein 2. (555 aa)
rwdd1RWD domain containing 1. (240 aa)
txnrd2Thioredoxin reductase 2, tandem duplicate 1. (512 aa)
Wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1284 aa)
ercc2Excision repair cross-complementation group 2. (655 aa)
LOC103458858Si:ch1073-358c10.1. (300 aa)
thg1ltRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (295 aa)
GPX2Glutathione peroxidase 2. (178 aa)
prdx4Peroxiredoxin 4. (261 aa)
txnipThioredoxin interacting protein. (408 aa)
NCOA7Nuclear receptor coactivator 7. (797 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
ENSPREP00000030126TLDc domain-containing protein. (246 aa)
ENSPREP00000030210Si:dkey-23i12.7. (134 aa)
impactImpact RWD domain protein. (320 aa)
znf622Zinc finger protein 622. (459 aa)
nox5NADPH oxidase, EF-hand calcium binding domain 5. (728 aa)
lonp1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (984 aa)
ENSPREP00000030584Cytochrome P450, family 1, subfamily C, polypeptide 2. (479 aa)
LOC103475853Pyr_redox_2 domain-containing protein. (552 aa)
dhcr2424-dehydrocholesterol reductase. (517 aa)
romo1Reactive oxygen species modulator 1. (79 aa)
prkaa2Non-specific serine/threonine protein kinase. (557 aa)
LOC103464252PP1c_bdg domain-containing protein. (528 aa)
LOC103466212Zgc:112052. (141 aa)
LOC103475730Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ercc6Excision repair cross-complementation group 6. (1402 aa)
ENSPREP00000031687PRA1 family protein. (54 aa)
LOC103465524PRA1 family protein. (190 aa)
EPXEosinophil peroxidase. (875 aa)
oser1Oxidative stress responsive serine-rich 1. (276 aa)
prkaa1Non-specific serine/threonine protein kinase. (637 aa)
NDUFS8NADH:ubiquinone oxidoreductase core subunit S8. (221 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (630 aa)
pink1PTEN induced kinase 1. (575 aa)
HDGFL3HDGF like 3. (185 aa)
LOC103459124Si:ch73-352p4.8. (487 aa)
slc25a24Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (475 aa)
ndufa12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (150 aa)
LOC103456761Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
LOC103475891Apoptosis inducing factor mitochondrion associated 1. (597 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1073 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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