(124 nodes) Negative regulation of cell adhesion network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103478004	Uncharacterized protein. (346 aa)
	il20rb	Fibronectin type-III domain-containing protein. (275 aa)
	ap1ar	Adaptor related protein complex 1 associated regulatory protein. (291 aa)
	LOC103480133	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	fgl1	Fibrinogen C-terminal domain-containing protein. (294 aa)
	LOC103477101	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (536 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (690 aa)
	ENSPREP00000003007	Plexin_cytopl domain-containing protein. (255 aa)
	LOC103466876	Plexin b1a. (2172 aa)
	ARHGAP6	Rho GTPase activating protein 6. (507 aa)
	LOC103466867	Plexin A1a. (1881 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (624 aa)
	LOC103477151	Uncharacterized protein. (158 aa)
	itch	E3 ubiquitin-protein ligase. (840 aa)
	plxna1	Sema domain-containing protein. (1891 aa)
	LOC103467753	CCAAT enhancer binding protein beta. (285 aa)
	vsir	V-set immunoregulatory receptor. (291 aa)
	LOC103479524	Si:dkeyp-66d1.7. (293 aa)
	myoc	Myocilin. (482 aa)
	LOC103469310	Uncharacterized protein. (287 aa)
	LOC103469311	Zgc:77748. (283 aa)
	LOC103457571	Si:ch211-203k16.3. (433 aa)
	tmem131l	Transmembrane 131 like. (1503 aa)
	c1qtnf6	C1q and TNF related 6b. (260 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (719 aa)
	il10	Interleukin 10. (229 aa)
	LOC103475332	Interferon regulatory factor. (291 aa)
	LOC103478985	Olfactomedin-like domain-containing protein. (500 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1049 aa)
	nexmif	Neurite extension and migration factor b. (1422 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (193 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	ENSPREP00000007343	Uncharacterized protein. (595 aa)
	ENSPREP00000007854	Uncharacterized protein. (143 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (623 aa)
	spry4	Sprouty homolog 4 (Drosophila). (283 aa)
	LOC103467068	TNFR-Cys domain-containing protein. (271 aa)
	LOC103466662	Tetraspanin. (237 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	LOC103461485	TNFR-Cys domain-containing protein. (179 aa)
	ENSPREP00000010806	Galectin. (325 aa)
	LOC103474828	Apolipoprotein A-Ib. (263 aa)
	ripor2	RHO family interacting cell polarization regulator 2. (1067 aa)
	glmn	Glomulin, FKBP associated protein a. (611 aa)
	pag1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (447 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (415 aa)
	LOC103480351	Uncharacterized protein. (282 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1110 aa)
	ENSPREP00000013399	Uncharacterized protein. (453 aa)
	arg2	Arginase. (346 aa)
	LOC103475843	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (950 aa)
	nf2	Neurofibromin 2b (merlin). (615 aa)
	ENSPREP00000014507	UBA_6 domain-containing protein. (200 aa)
	LOC103474919	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (762 aa)
	epcam	Epithelial cell adhesion molecule. (309 aa)
	LOC103480536	Methyltransferase like 3; Belongs to the MT-A70-like family. (287 aa)
	ajap1	Adherens junctions associated protein 1. (397 aa)
	tbcd	Tubulin folding cofactor D. (1231 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (573 aa)
	LOC103467098	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	fgl2	Fibrinogen-like 2a. (503 aa)
	gsc	Goosecoid. (237 aa)
	ENSPREP00000017998	Si:ch211-157b11.8. (259 aa)
	LOC103462757	IRF tryptophan pentad repeat domain-containing protein. (268 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1230 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	ENSPREP00000019059	Sema domain-containing protein. (485 aa)
	atp5f1b	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (517 aa)
	ENSPREP00000019776	C-C motif chemokine. (110 aa)
	plxna2	Sema domain-containing protein. (1911 aa)
	LOC103479802	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	crtam	Uncharacterized protein. (470 aa)
	socs6	Suppressor of cytokine signaling 6a. (459 aa)
	ENSPREP00000020773	Sema domain-containing protein. (427 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	ENSPREP00000021201	Uncharacterized protein. (128 aa)
	mbp	Myelin basic protein b. (142 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	ENSPREP00000021441	Leucine rich repeat containing 32. (619 aa)
	LOC103466445	ADAM metallopeptidase domain 10b. (781 aa)
	bcas3	BCAS3 microtubule associated cell migration factor. (666 aa)
	ENSPREP00000023056	Plexin_cytopl domain-containing protein. (53 aa)
	LOC103476825	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2011 aa)
	Plxnd1	Sema domain-containing protein. (627 aa)
	LOC103461155	Neurofibromin 2a (merlin). (394 aa)
	LOC103461156	Plexin_cytopl domain-containing protein. (238 aa)
	LOC103464828	E3 ubiquitin-protein ligase. (869 aa)
	ENSPREP00000023646	Plexin_cytopl domain-containing protein. (267 aa)
	LOC103481893	Arginase. (371 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	cbll1	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (476 aa)
	podxl	Uncharacterized protein. (437 aa)
	LOC103469771	Zinc finger protein 703. (579 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1119 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	cbfb	Core-binding factor subunit beta. (184 aa)
	plxnb2	Plexin b2b. (1848 aa)
	LOC103481123	Uncharacterized protein. (280 aa)
	LOC103481154	MARVEL domain-containing protein. (288 aa)
	LOC103473319	C2H2-type domain-containing protein. (515 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (271 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (639 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (604 aa)
	ENSPREP00000030326	TNFR-Cys domain-containing protein. (260 aa)
	Rgcc	Regulator of cell cycle. (134 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (779 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	ENSPREP00000030584	Cytochrome P450, family 1, subfamily C, polypeptide 2. (479 aa)
	cask	Uncharacterized protein; Belongs to the MAGUK family. (884 aa)
	LOC103472810	Fibrinogen C-terminal domain-containing protein. (510 aa)
	LOC103465508	Plexin b1b. (2191 aa)
	CD9	Tetraspanin. (210 aa)
	LOC103464268	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (211 aa)
	PLXNB2	Plexin B2. (1772 aa)
	LOC103467959	Plexin A2. (1163 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (280 aa)
	ripor3	RIPOR family member 3. (1001 aa)
	LOC103474638	Bone morphogenetic protein 16. (512 aa)
	LOC103456761	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	adam10	Uncharacterized protein. (645 aa)
	plxna4	Plexin A4. (1914 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000003007	ENSPREP00000019059	ENSPREP00000003007	ENSPREP00000019059	Plexin_cytopl domain-containing protein.	Sema domain-containing protein.	0.912
ENSPREP00000003007	ENSPREP00000020773	ENSPREP00000003007	ENSPREP00000020773	Plexin_cytopl domain-containing protein.	Sema domain-containing protein.	0.900
ENSPREP00000003007	LOC103467959	ENSPREP00000003007	ENSPREP00000033140	Plexin_cytopl domain-containing protein.	Plexin A2.	0.899
ENSPREP00000003007	Plxnd1	ENSPREP00000003007	ENSPREP00000023108	Plexin_cytopl domain-containing protein.	Sema domain-containing protein.	0.880
ENSPREP00000007343	LOC103475119	ENSPREP00000007343	ENSPREP00000027136	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.877
ENSPREP00000007854	LOC103480536	ENSPREP00000007854	ENSPREP00000015801	Uncharacterized protein.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.899
ENSPREP00000007854	cbll1	ENSPREP00000007854	ENSPREP00000024604	Uncharacterized protein.	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase.	0.547
ENSPREP00000010806	ENSPREP00000013399	ENSPREP00000010806	ENSPREP00000013399	Galectin.	Uncharacterized protein.	0.491
ENSPREP00000010806	LOC103478004	ENSPREP00000010806	ENSPREP00000016299	Galectin.	Uncharacterized protein.	0.663
ENSPREP00000010806	ptprc	ENSPREP00000010806	ENSPREP00000018309	Galectin.	Protein tyrosine phosphatase receptor type C.	0.591
ENSPREP00000013399	ENSPREP00000010806	ENSPREP00000013399	ENSPREP00000010806	Uncharacterized protein.	Galectin.	0.491
ENSPREP00000013399	LOC103467098	ENSPREP00000013399	ENSPREP00000016883	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.569
ENSPREP00000013399	LOC103475119	ENSPREP00000013399	ENSPREP00000027136	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.422
ENSPREP00000013399	LOC103478004	ENSPREP00000013399	ENSPREP00000016299	Uncharacterized protein.	Uncharacterized protein.	0.645
ENSPREP00000013399	il10	ENSPREP00000013399	ENSPREP00000005577	Uncharacterized protein.	Interleukin 10.	0.536
ENSPREP00000013399	ptpn11	ENSPREP00000013399	ENSPREP00000024560	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.569
ENSPREP00000013399	ptpn6	ENSPREP00000013399	ENSPREP00000016776	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.569
ENSPREP00000013399	ptprc	ENSPREP00000013399	ENSPREP00000018309	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.478
ENSPREP00000014507	rc3h1	ENSPREP00000014507	ENSPREP00000025906	UBA_6 domain-containing protein.	Ring finger and CCCH-type domains 1b.	0.406
ENSPREP00000019059	ENSPREP00000003007	ENSPREP00000019059	ENSPREP00000003007	Sema domain-containing protein.	Plexin_cytopl domain-containing protein.	0.912