(27 nodes) JNK cascade network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nod1	Nucleotide-binding oligomerization domain containing 1. (884 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1008 aa)
	gadd45a	Growth arrest and DNA-damage-inducible, alpha, a. (162 aa)
	Cdc42ep5	CDC42 effector protein (Rho GTPase binding) 5. (303 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (996 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	nphs1	NPHS1 adhesion molecule, nephrin. (1242 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103471253	Mitogen-activated protein kinase. (420 aa)
	map3k20	Uncharacterized protein. (796 aa)
	LOC103470783	CARD domain-containing protein. (434 aa)
	LOC103457268	Si:ch211-108d22.2. (2793 aa)
	mapk8	Mitogen-activated protein kinase. (426 aa)
	ercc6	Excision repair cross-complementation group 6. (1402 aa)
	LOC103476945	Mitogen-activated protein kinase. (360 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (788 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (418 aa)
	mapk8ip2	Mitogen-activated protein kinase 8 interacting protein 2. (1272 aa)
	LOC103463991	Growth arrest and DNA-damage-inducible, alpha, b. (245 aa)
	LOC103479332	Protein kinase domain-containing protein. (674 aa)
	ENSPREP00000019402	Protein kinase domain-containing protein. (201 aa)
	ENSPREP00000018384	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (290 aa)
	ENSPREP00000018072	Uncharacterized protein. (672 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000018072	ENSPREP00000018384	ENSPREP00000018072	ENSPREP00000018384	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.436
ENSPREP00000018072	LOC103470783	ENSPREP00000018072	ENSPREP00000025510	Uncharacterized protein.	CARD domain-containing protein.	0.531
ENSPREP00000018072	map3k7	ENSPREP00000018072	ENSPREP00000002180	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 7.	0.436
ENSPREP00000018072	ripk2	ENSPREP00000018072	ENSPREP00000009886	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.808
ENSPREP00000018384	ENSPREP00000018072	ENSPREP00000018384	ENSPREP00000018072	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.436
ENSPREP00000018384	ENSPREP00000019402	ENSPREP00000018384	ENSPREP00000019402	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.984
ENSPREP00000018384	LOC103457268	ENSPREP00000018384	ENSPREP00000031855	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Si:ch211-108d22.2.	0.436
ENSPREP00000018384	LOC103471253	ENSPREP00000018384	ENSPREP00000005621	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.938
ENSPREP00000018384	map2k4	ENSPREP00000018384	ENSPREP00000026466	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.984
ENSPREP00000018384	map2k7	ENSPREP00000018384	ENSPREP00000027032	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 7.	0.723
ENSPREP00000018384	map3k7	ENSPREP00000018384	ENSPREP00000002180	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 7.	0.901
ENSPREP00000018384	mapk10	ENSPREP00000018384	ENSPREP00000027709	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.934
ENSPREP00000018384	mapk8	ENSPREP00000018384	ENSPREP00000031694	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.942
ENSPREP00000018384	nod1	ENSPREP00000018384	ENSPREP00000015739	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Nucleotide-binding oligomerization domain containing 1.	0.443
ENSPREP00000018384	nod2	ENSPREP00000018384	ENSPREP00000010222	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Nucleotide-binding oligomerization domain containing 2.	0.436
ENSPREP00000018384	ripk2	ENSPREP00000018384	ENSPREP00000009886	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Receptor-interacting serine-threonine kinase 2.	0.701
ENSPREP00000019402	ENSPREP00000018384	ENSPREP00000019402	ENSPREP00000018384	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.984
ENSPREP00000019402	LOC103471253	ENSPREP00000019402	ENSPREP00000005621	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.995
ENSPREP00000019402	LOC103476945	ENSPREP00000019402	ENSPREP00000031358	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.860
ENSPREP00000019402	LOC103479332	ENSPREP00000019402	ENSPREP00000019978	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.725