(35 nodes) Aging network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C1QA	Complement C1q A chain. (259 aa)
	LOC103456761	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	LOC103471340	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	lonp1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (984 aa)
	LOC103467741	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1451 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	slc1a2	Amino acid transporter. (537 aa)
	ogg1	8-oxoguanine DNA glycosylase. (388 aa)
	fbxo4	F-box protein 4. (361 aa)
	LOC103470112	Ring finger protein 165b. (349 aa)
	LOC103479802	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (427 aa)
	podn	Podocan. (587 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (281 aa)
	sec63	SEC63 homolog, protein translocation regulator. (763 aa)
	LOC103468273	Guanine nucleotide binding protein (G protein), alpha 13b. (385 aa)
	LOC103468990	Amino acid transporter. (675 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	LOC103481631	Uncharacterized protein. (377 aa)
	edn1	Endothelin 1. (207 aa)
	LOC103467244	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. (597 aa)
	LOC103479092	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	pcgf1	Polycomb group ring finger 1. (285 aa)
	ENSPREP00000009510	Uncharacterized protein. (203 aa)
	gna12	G protein subunit alpha 12. (385 aa)
	LOC103473450	Ring finger protein 165a. (346 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	LOC103462732	Amino acid transporter. (559 aa)
	LOC103480104	Si:ch211-212k18.7. (245 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (617 aa)
	LOC103464471	Tumor necrosis factor receptor superfamily, member 1B. (441 aa)
	LOC103462295	Zgc:153993. (263 aa)
	LOC103470484	GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (481 aa)
	ENSPREP00000028306	NACHT domain-containing protein. (785 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QA	LOC103467244	ENSPREP00000033849	ENSPREP00000012821	Complement C1q A chain.	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	0.483
EDNRA	edn1	ENSPREP00000004362	ENSPREP00000012837	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.971
LOC103462295	casp9	ENSPREP00000002464	ENSPREP00000019950	Zgc:153993.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.499
LOC103467244	C1QA	ENSPREP00000012821	ENSPREP00000033849	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	Complement C1q A chain.	0.483
LOC103468273	LOC103471340	ENSPREP00000016861	ENSPREP00000034313	Guanine nucleotide binding protein (G protein), alpha 13b.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.927
LOC103468273	LOC103481631	ENSPREP00000016861	ENSPREP00000013619	Guanine nucleotide binding protein (G protein), alpha 13b.	Uncharacterized protein.	0.901
LOC103468273	gna12	ENSPREP00000016861	ENSPREP00000000495	Guanine nucleotide binding protein (G protein), alpha 13b.	G protein subunit alpha 12.	0.902
LOC103471340	LOC103468273	ENSPREP00000034313	ENSPREP00000016861	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), alpha 13b.	0.927
LOC103471340	LOC103481631	ENSPREP00000034313	ENSPREP00000013619	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.927
LOC103471340	edn1	ENSPREP00000034313	ENSPREP00000012837	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
LOC103471340	gna12	ENSPREP00000034313	ENSPREP00000000495	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 12.	0.927
LOC103481631	LOC103468273	ENSPREP00000013619	ENSPREP00000016861	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha 13b.	0.901
LOC103481631	LOC103471340	ENSPREP00000013619	ENSPREP00000034313	Uncharacterized protein.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.927
LOC103481631	gna12	ENSPREP00000013619	ENSPREP00000000495	Uncharacterized protein.	G protein subunit alpha 12.	0.902
casp9	LOC103462295	ENSPREP00000019950	ENSPREP00000002464	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Zgc:153993.	0.499
edn1	EDNRA	ENSPREP00000012837	ENSPREP00000004362	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.971
edn1	LOC103471340	ENSPREP00000012837	ENSPREP00000034313	Endothelin 1.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.998
ercc1	ercc2	ENSPREP00000015481	ENSPREP00000028527	Excision repair cross-complementation group 1.	Excision repair cross-complementation group 2.	0.873
ercc1	ogg1	ENSPREP00000015481	ENSPREP00000024234	Excision repair cross-complementation group 1.	8-oxoguanine DNA glycosylase.	0.579
ercc2	ercc1	ENSPREP00000028527	ENSPREP00000015481	Excision repair cross-complementation group 2.	Excision repair cross-complementation group 1.	0.873