(38 nodes) Associative learning network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Shank1	SAM domain-containing protein. (1628 aa)
	shank1	SH3 and multiple ankyrin repeat domains 1. (834 aa)
	srf	Serum response factor b. (570 aa)
	ENSPREP00000012437	Uncharacterized protein. (179 aa)
	tanc1	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1b. (1643 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	SRF	Serum response factor. (243 aa)
	nptx2	Neuronal pentraxin 2a. (449 aa)
	LOC103462684	Neuroplastin b. (379 aa)
	ENSPREP00000006501	Uncharacterized protein. (235 aa)
	LOC103471076	Uncharacterized protein. (136 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (148 aa)
	LOC103478925	Neuropilin (NRP) and tolloid (TLL)-like 1. (516 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (170 aa)
	LOC103467797	Rap guanine nucleotide exchange factor (GEF) 3. (878 aa)
	LOC103459124	Si:ch73-352p4.8. (487 aa)
	NRGN	Neurogranin. (90 aa)
	cln8	CLN8 transmembrane ER and ERGIC protein. (288 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (419 aa)
	lgmn	Legumain. (437 aa)
	LOC103473284	3-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
	adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
	ucn	Urotensin 1. (147 aa)
	LOC103481054	Uncharacterized protein. (2065 aa)
	RELN	Reelin. (3446 aa)
	LOC103471403	Uncharacterized protein. (217 aa)
	LOC103463007	SH3 and multiple ankyrin repeat domains 2a. (1709 aa)
	LOC103466425	Uncharacterized protein. (380 aa)
	LOC103466432	Si:ch73-330k17.3. (167 aa)
	LOC103466031	SH3 and multiple ankyrin repeat domains 3a. (1984 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	neto1	Neuropilin (NRP) and tolloid (TLL)-like 1, like. (558 aa)
	LOC103479350	Zgc:171558. (952 aa)
	mecp2	Methyl CpG binding protein 2. (982 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	LOC103457694	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	ppp1r1b	Protein phosphatase 1, regulatory (inhibitor) subunit 1B. (239 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006501	LOC103471076	ENSPREP00000006501	ENSPREP00000006476	Uncharacterized protein.	Uncharacterized protein.	0.946
LOC103467797	adcy3	ENSPREP00000033162	ENSPREP00000027340	Rap guanine nucleotide exchange factor (GEF) 3.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.908
LOC103471076	ENSPREP00000006501	ENSPREP00000006476	ENSPREP00000006501	Uncharacterized protein.	Uncharacterized protein.	0.946
LOC103473284	hmgcr	ENSPREP00000027438	ENSPREP00000018171	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
PPP1R1B	cdk5	ENSPREP00000034263	ENSPREP00000011776	Protein phosphatase 1 regulatory inhibitor subunit 1B.	Cyclin-dependent kinase 5.	0.740
Shank1	shank1	ENSPREP00000015974	ENSPREP00000015953	SAM domain-containing protein.	SH3 and multiple ankyrin repeat domains 1.	0.896
adcy3	LOC103467797	ENSPREP00000027340	ENSPREP00000033162	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor (GEF) 3.	0.908
cdk5	PPP1R1B	ENSPREP00000011776	ENSPREP00000034263	Cyclin-dependent kinase 5.	Protein phosphatase 1 regulatory inhibitor subunit 1B.	0.740
cdk5	ppp1r1b	ENSPREP00000011776	ENSPREP00000016248	Cyclin-dependent kinase 5.	Protein phosphatase 1, regulatory (inhibitor) subunit 1B.	0.740
hmgcr	LOC103473284	ENSPREP00000018171	ENSPREP00000027438	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
ppp1r1b	cdk5	ENSPREP00000016248	ENSPREP00000011776	Protein phosphatase 1, regulatory (inhibitor) subunit 1B.	Cyclin-dependent kinase 5.	0.740
shank1	Shank1	ENSPREP00000015953	ENSPREP00000015974	SH3 and multiple ankyrin repeat domains 1.	SAM domain-containing protein.	0.896